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Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial.

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Title: Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial.
Authors: Fischer U; Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Neurology, University Hospital Basel, University of Basel, Basel, Switzerland. Electronic address: urs.fischer@usb.ch., Kaesmacher J; University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Strbian D; Department of Neurology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland., Eker O; Department of Neuroradiology, Hospices Civils de Lyon, Lyon, France., Cognard C; Department of Diagnostic and Therapeutic Neuroradiology, Centre Hospitalier Universitaire de Toulouse, Toulouse, France., Plattner PS; Neuro Clinical Trial Unit, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Bütikofer L; CTU Bern, University of Bern, Bern, Switzerland., Mordasini P; University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Deppeler S; Neuro Clinical Trial Unit, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Pereira VM; Division of Neurosurgery, Department of Surgery and Medical Imaging, St Michael's Hospital, University of Toronto, Toronto, ON, Canada., Albucher JF; Department of Neurology, Centre Hospitalier Universitaire de Toulouse, Toulouse, France., Darcourt J; Department of Diagnostic and Therapeutic Neuroradiology, Centre Hospitalier Universitaire de Toulouse, Toulouse, France., Bourcier R; Department of Diagnostic and Interventional Neuroradiology, Centre Hospitalier Universitaire de Nantes, Nantes Université, Nantes, France., Benoit G; Department of Neurology, Centre Hospitalier Universitaire de Nantes, Nantes Université, Nantes, France., Papagiannaki C; Department of Radiology, CHU Rouen, Rouen, France., Ozkul-Wermester O; Department of Neurology, CHU Rouen, Rouen, France., Sibolt G; Department of Neurology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland., Tiainen M; Department of Neurology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland., Gory B; Department of Diagnostic and Therapeutic Neuroradiology, INSERM U1254, CHRU-Nancy, Université de Lorraine, Nancy, France., Richard S; Department of Neurology, Stroke Unit, INSERM U1116, CHRU-Nancy, Université de Lorraine, Nancy, France., Liman J; Department of Neurology, University Medical Center Goettingen, Goettingen, Germany., Ernst MS; Department of Neuroradiology, University Medical Center Goettingen, Goettingen, Germany., Boulanger M; Department of Neurology, CHU Caen Normandie, University Caen Normandie, INSERM U1237, Caen, France., Barbier C; Department of Neuroradiology, CHU Caen Normandie, University Caen Normandie, INSERM U1237, Caen, France., Mechtouff L; Department of Vascular Neurology, Hospices Civils de Lyon, Lyon, France., Zhang L; Department of Neurology, St George's University Hospital NHS Foundation Trust, London, UK., Marnat G; Department of Interventional and Diagnostic Neuroradiology, CHU Bordeaux, University of Bordeaux, Bordeaux, France., Sibon I; Stroke Unit, CHU Bordeaux, University of Bordeaux, Bordeaux, France., Nikoubashman O; Department of Neuroradiology, University Hospital RWTH Aachen, Aachen, Germany., Reich A; Department of Neurology, University Hospital RWTH Aachen, Aachen, Germany., Consoli A; Department of Stroke and Diagnostic and Interventional Neuroradiology, Foch Hospital, Suresnes, France., Lapergue B; Department of Stroke and Diagnostic and Interventional Neuroradiology, Foch Hospital, Suresnes, France., Ribo M; Stroke Unit, Department of Neurology, Hospital Vall d'Heborn, Barcelona, Spain., Tomasello A; Interventional Neuroradiology, Department of Radiology, Hospital Vall d'Heborn, Barcelona, Spain., Saleme S; Department of Neuroradiology, University Hospital of Limoges, Limoges, France., Macian F; Department of Neurology, University Hospital of Limoges, Limoges, France., Moulin S; Department of Neurology, CHU Reims, Reims, France., Pagano P; Department of Neuroradiology, CHU Reims, Reims, France., Saliou G; Service of Interventional and Diagnostic Radiology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland., Carrera E; Department of Neurology, Hôpitaux Universitaires de Genève, Geneva, Switzerland., Janot K; Department of Diagnostic and Interventional Neuroradiology, Tours University Hospital, Tours, France., Hernández-Pérez M; Stroke Unit, Department of Neurosciences, University Hospital Germans Trias i Pujol, Barcelona, Spain., Pop R; Department of Interventional Neuroradiology, Strasbourg University Hospitals, Strasbourg, France., Schiava LD; Department of Neurology, Lille University Hospital, Lille, France., Luft AR; Department of Neurology, University Hospital of Zurich, Zurich, Switzerland; Cereneo, Center for Neurology and Rehabilitation, Vitznau, Switzerland., Piotin M; Department of Interventional Neuroradiology, Fondation Rothschild Hospital, Paris, France., Gentric JC; Department of Neuroradiology, Brest University Hospital, Brest, France; GETBO, INSERM Unit UMR 1034, Brest, France., Pikula A; Division of Neurology, Department of Medicine, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada., Pfeilschifter W; Department of Neurology, University Hospital Frankfurt, Frankfurt, Germany., Arnold M; Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Siddiqui AH; Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, New York, NY, USA., Froehler MT; Vanderbilt Cerebrovascular Program, Vanderbilt University Medical Center, Nashville, TN, USA., Furlan AJ; School of Medicine, Case Western Reserve University, Cleveland, OH, USA., Chapot R; Department of Intracranial Endovascular Therapy, Alfried Krupp Krankenhaus Essen, Essen, Germany., Wiesmann M; Department of Neuroradiology, University Hospital RWTH Aachen, Aachen, Germany., Machi P; Department of Neuroradiology, Hôpitaux Universitaires de Genève, Geneva, Switzerland., Diener HC; Department of Neuroepidemiology, Institute for Medical Informatics, Biometry and Epidemiology IMIBE), Essen, Germany., Kulcsar Z; Department of Neuroradiology, University Hospital of Zurich, Zurich, Switzerland., Bonati LH; Department of Neurology, University Hospital Basel, University of Basel, Basel, Switzerland., Bassetti CL; Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Mazighi M; Department of Neurology, Lariboisière Hospital, University of Paris, FHU NeuroVasc, INSERM 1148, Paris, France; Department of Interventional Neuroradiology, Adolphe de Rothschild Hospital Foundation, University of Paris, FHU NeuroVasc, INSERM 1148, Paris, France., Liebeskind DS; Department of Neurology and Comprehensive Stroke Center, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Saver JL; Department of Neurology and Comprehensive Stroke Center, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Gralla J; University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Corporate Authors: SWIFT DIRECT Collaborators
Source: Lancet (London, England) [Lancet] 2022 Jul 09; Vol. 400 (10346), pp. 104-115.
Publication Type: Equivalence Trial; Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 2985213R Publication Model: Print Cited Medium: Internet ISSN: 1474-547X (Electronic) Linking ISSN: 01406736 NLM ISO Abbreviation: Lancet Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial.
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  Data: <searchLink fieldCode="AU" term="%22Fischer+U%22">Fischer U</searchLink>; Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Neurology, University Hospital Basel, University of Basel, Basel, Switzerland. Electronic address: urs.fischer@usb.ch.<br /><searchLink fieldCode="AU" term="%22Kaesmacher+J%22">Kaesmacher J</searchLink>; University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Strbian+D%22">Strbian D</searchLink>; Department of Neurology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Eker+O%22">Eker O</searchLink>; Department of Neuroradiology, Hospices Civils de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Cognard+C%22">Cognard C</searchLink>; Department of Diagnostic and Therapeutic Neuroradiology, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Plattner+PS%22">Plattner PS</searchLink>; Neuro Clinical Trial Unit, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bütikofer+L%22">Bütikofer L</searchLink>; CTU Bern, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mordasini+P%22">Mordasini P</searchLink>; University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Deppeler+S%22">Deppeler S</searchLink>; Neuro Clinical Trial Unit, Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Pereira+VM%22">Pereira VM</searchLink>; Division of Neurosurgery, Department of Surgery and Medical Imaging, St Michael's Hospital, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Albucher+JF%22">Albucher JF</searchLink>; Department of Neurology, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Darcourt+J%22">Darcourt J</searchLink>; Department of Diagnostic and Therapeutic Neuroradiology, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Bourcier+R%22">Bourcier R</searchLink>; Department of Diagnostic and Interventional Neuroradiology, Centre Hospitalier Universitaire de Nantes, Nantes Université, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Benoit+G%22">Benoit G</searchLink>; Department of Neurology, Centre Hospitalier Universitaire de Nantes, Nantes Université, Nantes, France.<br /><searchLink fieldCode="AU" term="%22Papagiannaki+C%22">Papagiannaki C</searchLink>; Department of Radiology, CHU Rouen, Rouen, France.<br /><searchLink fieldCode="AU" term="%22Ozkul-Wermester+O%22">Ozkul-Wermester O</searchLink>; Department of Neurology, CHU Rouen, Rouen, France.<br /><searchLink fieldCode="AU" term="%22Sibolt+G%22">Sibolt G</searchLink>; Department of Neurology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Tiainen+M%22">Tiainen M</searchLink>; Department of Neurology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Gory+B%22">Gory B</searchLink>; Department of Diagnostic and Therapeutic Neuroradiology, INSERM U1254, CHRU-Nancy, Université de Lorraine, Nancy, France.<br /><searchLink fieldCode="AU" term="%22Richard+S%22">Richard S</searchLink>; Department of Neurology, Stroke Unit, INSERM U1116, CHRU-Nancy, Université de Lorraine, Nancy, France.<br /><searchLink fieldCode="AU" term="%22Liman+J%22">Liman J</searchLink>; Department of Neurology, University Medical Center Goettingen, Goettingen, Germany.<br /><searchLink fieldCode="AU" term="%22Ernst+MS%22">Ernst MS</searchLink>; Department of Neuroradiology, University Medical Center Goettingen, Goettingen, Germany.<br /><searchLink fieldCode="AU" term="%22Boulanger+M%22">Boulanger M</searchLink>; Department of Neurology, CHU Caen Normandie, University Caen Normandie, INSERM U1237, Caen, France.<br /><searchLink fieldCode="AU" term="%22Barbier+C%22">Barbier C</searchLink>; Department of Neuroradiology, CHU Caen Normandie, University Caen Normandie, INSERM U1237, Caen, France.<br /><searchLink fieldCode="AU" term="%22Mechtouff+L%22">Mechtouff L</searchLink>; 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Service of Interventional and Diagnostic Radiology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.<br /><searchLink fieldCode="AU" term="%22Carrera+E%22">Carrera E</searchLink>; Department of Neurology, Hôpitaux Universitaires de Genève, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Janot+K%22">Janot K</searchLink>; Department of Diagnostic and Interventional Neuroradiology, Tours University Hospital, Tours, France.<br /><searchLink fieldCode="AU" term="%22Hernández-Pérez+M%22">Hernández-Pérez M</searchLink>; Stroke Unit, Department of Neurosciences, University Hospital Germans Trias i Pujol, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Pop+R%22">Pop R</searchLink>; Department of Interventional Neuroradiology, Strasbourg University Hospitals, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Schiava+LD%22">Schiava LD</searchLink>; Department of Neurology, Lille University Hospital, Lille, France.<br /><searchLink fieldCode="AU" term="%22Luft+AR%22">Luft AR</searchLink>; Department of Neurology, University Hospital of Zurich, Zurich, Switzerland; Cereneo, Center for Neurology and Rehabilitation, Vitznau, Switzerland.<br /><searchLink fieldCode="AU" term="%22Piotin+M%22">Piotin M</searchLink>; Department of Interventional Neuroradiology, Fondation Rothschild Hospital, Paris, France.<br /><searchLink fieldCode="AU" term="%22Gentric+JC%22">Gentric JC</searchLink>; Department of Neuroradiology, Brest University Hospital, Brest, France; GETBO, INSERM Unit UMR 1034, Brest, France.<br /><searchLink fieldCode="AU" term="%22Pikula+A%22">Pikula A</searchLink>; Division of Neurology, Department of Medicine, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Pfeilschifter+W%22">Pfeilschifter W</searchLink>; Department of Neurology, University Hospital Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Arnold+M%22">Arnold M</searchLink>; Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Siddiqui+AH%22">Siddiqui AH</searchLink>; Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Froehler+MT%22">Froehler MT</searchLink>; Vanderbilt Cerebrovascular Program, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Furlan+AJ%22">Furlan AJ</searchLink>; School of Medicine, Case Western Reserve University, Cleveland, OH, USA.<br /><searchLink fieldCode="AU" term="%22Chapot+R%22">Chapot R</searchLink>; Department of Intracranial Endovascular Therapy, Alfried Krupp Krankenhaus Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Wiesmann+M%22">Wiesmann M</searchLink>; Department of Neuroradiology, University Hospital RWTH Aachen, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Machi+P%22">Machi P</searchLink>; Department of Neuroradiology, Hôpitaux Universitaires de Genève, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Diener+HC%22">Diener HC</searchLink>; Department of Neuroepidemiology, Institute for Medical Informatics, Biometry and Epidemiology IMIBE), Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Kulcsar+Z%22">Kulcsar Z</searchLink>; Department of Neuroradiology, University Hospital of Zurich, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bonati+LH%22">Bonati LH</searchLink>; Department of Neurology, University Hospital Basel, University of Basel, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bassetti+CL%22">Bassetti CL</searchLink>; Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mazighi+M%22">Mazighi M</searchLink>; Department of Neurology, Lariboisière Hospital, University of Paris, FHU NeuroVasc, INSERM 1148, Paris, France; Department of Interventional Neuroradiology, Adolphe de Rothschild Hospital Foundation, University of Paris, FHU NeuroVasc, INSERM 1148, Paris, France.<br /><searchLink fieldCode="AU" term="%22Liebeskind+DS%22">Liebeskind DS</searchLink>; Department of Neurology and Comprehensive Stroke Center, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Saver+JL%22">Saver JL</searchLink>; Department of Neurology and Comprehensive Stroke Center, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Gralla+J%22">Gralla J</searchLink>; University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
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  Data: <searchLink fieldCode="JN" term="%222985213R%22">Lancet (London, England)</searchLink> [Lancet] 2022 Jul 09; Vol. 400 (10346), pp. 104-115.
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          Name:
            NameFull: Pagano P
      – PersonEntity:
          Name:
            NameFull: Saliou G
      – PersonEntity:
          Name:
            NameFull: Carrera E
      – PersonEntity:
          Name:
            NameFull: Janot K
      – PersonEntity:
          Name:
            NameFull: Hernández-Pérez M
      – PersonEntity:
          Name:
            NameFull: Pop R
      – PersonEntity:
          Name:
            NameFull: Schiava LD
      – PersonEntity:
          Name:
            NameFull: Luft AR
      – PersonEntity:
          Name:
            NameFull: Piotin M
      – PersonEntity:
          Name:
            NameFull: Gentric JC
      – PersonEntity:
          Name:
            NameFull: Pikula A
      – PersonEntity:
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            NameFull: Pfeilschifter W
      – PersonEntity:
          Name:
            NameFull: Arnold M
      – PersonEntity:
          Name:
            NameFull: Siddiqui AH
      – PersonEntity:
          Name:
            NameFull: Froehler MT
      – PersonEntity:
          Name:
            NameFull: Furlan AJ
      – PersonEntity:
          Name:
            NameFull: Chapot R
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          Name:
            NameFull: Wiesmann M
      – PersonEntity:
          Name:
            NameFull: Machi P
      – PersonEntity:
          Name:
            NameFull: Diener HC
      – PersonEntity:
          Name:
            NameFull: Kulcsar Z
      – PersonEntity:
          Name:
            NameFull: Bonati LH
      – PersonEntity:
          Name:
            NameFull: Bassetti CL
      – PersonEntity:
          Name:
            NameFull: Mazighi M
      – PersonEntity:
          Name:
            NameFull: Liebeskind DS
      – PersonEntity:
          Name:
            NameFull: Saver JL
      – PersonEntity:
          Name:
            NameFull: Gralla J
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 09
              M: 07
              Text: 2022 Jul 09
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-electronic
              Value: 1474-547X
          Numbering:
            – Type: volume
              Value: 400
            – Type: issue
              Value: 10346
          Titles:
            – TitleFull: Lancet (London, England)
              Type: main
ResultId 1