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Regulatory enhancer profiling of mesenchymal-type gastric cancer reveals subtype-specific epigenomic landscapes and targetable vulnerabilities.

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Title: Regulatory enhancer profiling of mesenchymal-type gastric cancer reveals subtype-specific epigenomic landscapes and targetable vulnerabilities.
Authors: Ho SWT; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Sheng T; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Department of Biochemistry, National University of Singapore, Singapore., Xing M; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Ooi WF; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Xu C; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Sundar R; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Department of Haematology-Oncology, National University Cancer Institute, National University Hospital, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; The N.1 Institute for Health, National University of Singapore, Singapore.; Singapore Gastric Cancer Consortium, Singapore., Huang KK; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Li Z; Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore., Kumar V; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Ramnarayanan K; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Zhu F; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Srivastava S; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Isa ZFBA; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Anene-Nzelu CG; Cardiovascular Research Institute, National University Health System, Singapore.; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.; Montreal Heart Institute, Quebec, Quebec, Canada.; Department of Medicine, University of Montreal, Quebec, Quebec, Canada., Razavi-Mohseni M; Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Shigaki D; Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Ma H; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Tan ALK; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Ong X; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Lee MH; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Tay ST; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore., Guo YA; Computational and Systems Biology, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Huang W; Computational and Systems Biology, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Li S; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Beer MA; Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Foo RSY; Cardiovascular Research Institute, National University Health System, Singapore.; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Teh M; Department of Pathology, National University of Singapore, Singapore., Skanderup AJ; Computational and Systems Biology, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore., Teh BT; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore.; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore., Tan P; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore gmstanp@duke-nus.edu.sg.; Cancer Science Institute of Singapore, National University of Singapore, Singapore.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Singapore Gastric Cancer Consortium, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Cellular and Molecular Research, National Cancer Centre, Singapore.; SingHealth/Duke-NUS Institute of Precision Medicine, National Heart Centre Singapore, Singapore.
Source: Gut [Gut] 2023 Feb; Vol. 72 (2), pp. 226-241. Date of Electronic Publication: 2022 Jul 11.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: British Medical Assn Country of Publication: England NLM ID: 2985108R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-3288 (Electronic) Linking ISSN: 00175749 NLM ISO Abbreviation: Gut Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Regulatory enhancer profiling of mesenchymal-type gastric cancer reveals subtype-specific epigenomic landscapes and targetable vulnerabilities.
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  Data: <searchLink fieldCode="AU" term="%22Ho+SWT%22">Ho SWT</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Sheng+T%22">Sheng T</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Department of Biochemistry, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Xing+M%22">Xing M</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Ooi+WF%22">Ooi WF</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.<br /><searchLink fieldCode="AU" term="%22Xu+C%22">Xu C</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Sundar+R%22">Sundar R</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Department of Haematology-Oncology, National University Cancer Institute, National University Hospital, Singapore.; Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; The N.1 Institute for Health, National University of Singapore, Singapore.; Singapore Gastric Cancer Consortium, Singapore.<br /><searchLink fieldCode="AU" term="%22Huang+KK%22">Huang KK</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Kumar+V%22">Kumar V</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Ramnarayanan+K%22">Ramnarayanan K</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Zhu+F%22">Zhu F</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Srivastava+S%22">Srivastava S</searchLink>; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Isa+ZFBA%22">Isa ZFBA</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.<br /><searchLink fieldCode="AU" term="%22Anene-Nzelu+CG%22">Anene-Nzelu CG</searchLink>; Cardiovascular Research Institute, National University Health System, Singapore.; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.; Montreal Heart Institute, Quebec, Quebec, Canada.; Department of Medicine, University of Montreal, Quebec, Quebec, Canada.<br /><searchLink fieldCode="AU" term="%22Razavi-Mohseni+M%22">Razavi-Mohseni M</searchLink>; Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Shigaki+D%22">Shigaki D</searchLink>; Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Ma+H%22">Ma H</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+ALK%22">Tan ALK</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Ong+X%22">Ong X</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Lee+MH%22">Lee MH</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Tay+ST%22">Tay ST</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.<br /><searchLink fieldCode="AU" term="%22Guo+YA%22">Guo YA</searchLink>; Computational and Systems Biology, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.<br /><searchLink fieldCode="AU" term="%22Huang+W%22">Huang W</searchLink>; Computational and Systems Biology, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Beer+MA%22">Beer MA</searchLink>; Department of Biomedical Engineering and McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Foo+RSY%22">Foo RSY</searchLink>; Cardiovascular Research Institute, National University Health System, Singapore.; Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.<br /><searchLink fieldCode="AU" term="%22Teh+M%22">Teh M</searchLink>; Department of Pathology, National University of Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Skanderup+AJ%22">Skanderup AJ</searchLink>; Computational and Systems Biology, Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.<br /><searchLink fieldCode="AU" term="%22Teh+BT%22">Teh BT</searchLink>; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore.; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+P%22">Tan P</searchLink>; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore gmstanp@duke-nus.edu.sg.; Cancer Science Institute of Singapore, National University of Singapore, Singapore.; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore.; Singapore Gastric Cancer Consortium, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Cellular and Molecular Research, National Cancer Centre, Singapore.; SingHealth/Duke-NUS Institute of Precision Medicine, National Heart Centre Singapore, Singapore.
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  Data: <searchLink fieldCode="JN" term="%222985108R%22">Gut</searchLink> [Gut] 2023 Feb; Vol. 72 (2), pp. 226-241. <i>Date of Electronic Publication: </i>2022 Jul 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22British+Medical+Assn%22">British Medical Assn </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>2985108R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1468-3288 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200175749%22">00175749 </searchLink><i>NLM ISO Abbreviation: </i>Gut <i>Subsets: </i>MEDLINE
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        Value: 10.1136/gutjnl-2021-326483
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