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An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides.

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Title: An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides.
Authors: Baker YR; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK., Thorpe C; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK., Chen J; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK., Poller LM; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK., Cox L; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK., Kumar P; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK., Lim WF; Department of Paediatrics, University of Oxford, LGC building, South Parks Road, Oxford, OX1 3QX, UK., Lie L; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK., McClorey G; Department of Paediatrics, University of Oxford, LGC building, South Parks Road, Oxford, OX1 3QX, UK., Epple S; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK., Singleton D; ATDBio Ltd, School of Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, UK., McDonough MA; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK., Hardwick JS; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK., Christensen KE; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK., Wood MJA; Department of Paediatrics, University of Oxford, LGC building, South Parks Road, Oxford, OX1 3QX, UK., Hall JP; Department of Pharmacy, Chemistry and Pharmacy Building, University of Reading, Whiteknights, Reading, RG6 6AD, UK., El-Sagheer AH; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.; Department of Science and Mathematics, Suez University, Faculty of Petroleum and Mining Engineering, Suez, 43721, Egypt., Brown T; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK. tom.brown@chem.ox.ac.uk.
Source: Nature communications [Nat Commun] 2022 Jul 12; Vol. 13 (1), pp. 4036. Date of Electronic Publication: 2022 Jul 12.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides.
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  Data: <searchLink fieldCode="AU" term="%22Baker+YR%22">Baker YR</searchLink>; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.<br /><searchLink fieldCode="AU" term="%22Thorpe+C%22">Thorpe C</searchLink>; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.<br /><searchLink fieldCode="AU" term="%22Poller+LM%22">Poller LM</searchLink>; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.<br /><searchLink fieldCode="AU" term="%22Cox+L%22">Cox L</searchLink>; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.<br /><searchLink fieldCode="AU" term="%22Kumar+P%22">Kumar P</searchLink>; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.<br /><searchLink fieldCode="AU" term="%22Lim+WF%22">Lim WF</searchLink>; Department of Paediatrics, University of Oxford, LGC building, South Parks Road, Oxford, OX1 3QX, UK.<br /><searchLink fieldCode="AU" term="%22Lie+L%22">Lie L</searchLink>; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.<br /><searchLink fieldCode="AU" term="%22McClorey+G%22">McClorey G</searchLink>; Department of Paediatrics, University of Oxford, LGC building, South Parks Road, Oxford, OX1 3QX, UK.<br /><searchLink fieldCode="AU" term="%22Epple+S%22">Epple S</searchLink>; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.<br /><searchLink fieldCode="AU" term="%22Singleton+D%22">Singleton D</searchLink>; ATDBio Ltd, School of Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, UK.<br /><searchLink fieldCode="AU" term="%22McDonough+MA%22">McDonough MA</searchLink>; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.<br /><searchLink fieldCode="AU" term="%22Hardwick+JS%22">Hardwick JS</searchLink>; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.<br /><searchLink fieldCode="AU" term="%22Christensen+KE%22">Christensen KE</searchLink>; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.<br /><searchLink fieldCode="AU" term="%22Wood+MJA%22">Wood MJA</searchLink>; Department of Paediatrics, University of Oxford, LGC building, South Parks Road, Oxford, OX1 3QX, UK.<br /><searchLink fieldCode="AU" term="%22Hall+JP%22">Hall JP</searchLink>; Department of Pharmacy, Chemistry and Pharmacy Building, University of Reading, Whiteknights, Reading, RG6 6AD, UK.<br /><searchLink fieldCode="AU" term="%22El-Sagheer+AH%22">El-Sagheer AH</searchLink>; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK.; Department of Science and Mathematics, Suez University, Faculty of Petroleum and Mining Engineering, Suez, 43721, Egypt.<br /><searchLink fieldCode="AU" term="%22Brown+T%22">Brown T</searchLink>; Department of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford, OX1 3TA, UK. tom.brown@chem.ox.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2022 Jul 12; Vol. 13 (1), pp. 4036. <i>Date of Electronic Publication: </i>2022 Jul 12.
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