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Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance.

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Title: Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance.
Authors: Wrobel L; Department of Medical Genetics, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, United Kingdom.; UK Dementia Research Institute, University of Cambridge, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, United Kingdom., Hill SM; Department of Medical Genetics, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, United Kingdom.; UK Dementia Research Institute, University of Cambridge, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, United Kingdom.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 413 45, Gothenburg, Sweden., Djajadikerta A; Department of Medical Genetics, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, United Kingdom.; UK Dementia Research Institute, University of Cambridge, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, United Kingdom., Fernandez-Estevez M; Department of Medical Genetics, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, United Kingdom.; UK Dementia Research Institute, University of Cambridge, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, United Kingdom., Karabiyik C; Department of Medical Genetics, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, United Kingdom.; UK Dementia Research Institute, University of Cambridge, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, United Kingdom., Ashkenazi A; Department of Medical Genetics, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, United Kingdom., Barratt VJ; Department of Medical Genetics, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, United Kingdom.; UK Dementia Research Institute, University of Cambridge, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, United Kingdom., Stamatakou E; Department of Medical Genetics, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, United Kingdom.; UK Dementia Research Institute, University of Cambridge, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, United Kingdom., Gunnarsson A; Biophysics SE, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Rasmusson T; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Boston, MA, USA., Miele EW; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Boston, MA, USA., Beaton N; Biognosys AG, Wagistrasse 21, 8952, Schlieren, Switzerland., Bruderer R; Biognosys AG, Wagistrasse 21, 8952, Schlieren, Switzerland., Feng Y; Biognosys AG, Wagistrasse 21, 8952, Schlieren, Switzerland., Reiter L; Biognosys AG, Wagistrasse 21, 8952, Schlieren, Switzerland., Castaldi MP; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Boston, MA, USA., Jarvis R; Discovery UK, Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Tan K; Discovery UK, Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Bürli RW; Discovery UK, Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Rubinsztein DC; Department of Medical Genetics, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, United Kingdom. dcr1000@cam.ac.uk.; UK Dementia Research Institute, University of Cambridge, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, United Kingdom. dcr1000@cam.ac.uk.
Source: Nature communications [Nat Commun] 2022 Jul 16; Vol. 13 (1), pp. 4146. Date of Electronic Publication: 2022 Jul 16.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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Department of Medical Genetics, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, United Kingdom.; UK Dementia Research Institute, University of Cambridge, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Fernandez-Estevez+M%22">Fernandez-Estevez M</searchLink>; Department of Medical Genetics, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, United Kingdom.; UK Dementia Research Institute, University of Cambridge, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Karabiyik+C%22">Karabiyik C</searchLink>; Department of Medical Genetics, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, United Kingdom.; 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Department of Medical Genetics, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, United Kingdom.; UK Dementia Research Institute, University of Cambridge, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gunnarsson+A%22">Gunnarsson A</searchLink>; Biophysics SE, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Rasmusson+T%22">Rasmusson T</searchLink>; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Miele+EW%22">Miele EW</searchLink>; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Beaton+N%22">Beaton N</searchLink>; Biognosys AG, Wagistrasse 21, 8952, Schlieren, Switzerland.<br /><searchLink fieldCode="AU" term="%22Bruderer+R%22">Bruderer R</searchLink>; 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Department of Medical Genetics, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, United Kingdom. dcr1000@cam.ac.uk.; UK Dementia Research Institute, University of Cambridge, Cambridge Institute for Medical Research, The Keith Peters Building, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0XY, United Kingdom. dcr1000@cam.ac.uk.
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