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Upfront Biology-Guided Therapy in Diffuse Intrinsic Pontine Glioma: Therapeutic, Molecular, and Biomarker Outcomes from PNOC003.

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Title: Upfront Biology-Guided Therapy in Diffuse Intrinsic Pontine Glioma: Therapeutic, Molecular, and Biomarker Outcomes from PNOC003.
Authors: Kline C; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Jain P; Division of Neurosurgery, Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Kilburn L; Department of Hematology and Oncology, Children's National Hospital, Washington, DC., Bonner ER; Center for Genetic Medicine Research, Children's National Hospital, Washington, DC.; Institute for Biomedical Sciences, The George Washington University School of Medicine and Health Sciences, Washington, DC., Gupta N; Department of Neurological Surgery, University of California, San Francisco, California., Crawford JR; Department of Neuroscience, University of California, San Diego, California.; Rady Children's Hospital San Diego, San Diego, California., Banerjee A; Department of Neurological Surgery, University of California, San Francisco, California.; Department of Pediatrics, University of California, San Francisco, California., Packer RJ; Center for Neuroscience and Behavioral Medicine, Children's National Hospital, Washington, DC., Villanueva-Meyer J; Department of Radiology and Biomedical Imaging, University of California, San Francisco, California., Luks T; Department of Radiology and Biomedical Imaging, University of California, San Francisco, California., Zhang Y; Department of Neurological Surgery, University of California, San Francisco, California.; Department of Epidemiology and Biostatistics, University of California, San Francisco, California., Kambhampati M; Center for Genetic Medicine Research, Children's National Hospital, Washington, DC., Zhang J; Department of Neurology, University of California, San Francisco, California., Yadavilli S; Center for Genetic Medicine Research, Children's National Hospital, Washington, DC., Zhang B; Division of Neurosurgery, Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Gaonkar KS; Division of Neurosurgery, Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Rokita JL; Division of Neurosurgery, Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Kraya A; Division of Neurosurgery, Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Kuhn J; College of Pharmacy, University of Texas Health Science Center, San Antonio, Texas., Liang W; Translational Genomic Research Institute (TGEN), Phoenix, Arizona., Byron S; Translational Genomic Research Institute (TGEN), Phoenix, Arizona., Berens M; Translational Genomic Research Institute (TGEN), Phoenix, Arizona., Molinaro A; Department of Neurological Surgery, University of California, San Francisco, California.; Department of Epidemiology and Biostatistics, University of California, San Francisco, California., Prados M; Department of Neurological Surgery, University of California, San Francisco, California., Resnick A; Division of Neurosurgery, Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Waszak SM; Department of Neurology, University of California, San Francisco, California.; Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, Oslo, Norway.; Division of Pediatric and Adolescent Medicine, Department of Pediatric Research, Rikshospitalet, Oslo University Hospital, Oslo, Norway., Nazarian J; Center for Genetic Medicine Research, Children's National Hospital, Washington, DC.; Institute for Biomedical Sciences, The George Washington University School of Medicine and Health Sciences, Washington, DC.; Department of Oncology, University Children's Hospital Zürich, Zürich, Switzerland., Mueller S; Department of Neurological Surgery, University of California, San Francisco, California.; Department of Pediatrics, University of California, San Francisco, California.; Department of Neurology, University of California, San Francisco, California.; Department of Oncology, University Children's Hospital Zürich, Zürich, Switzerland.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2022 Sep 15; Vol. 28 (18), pp. 3965-3978.
Publication Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Upfront Biology-Guided Therapy in Diffuse Intrinsic Pontine Glioma: Therapeutic, Molecular, and Biomarker Outcomes from PNOC003.
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  Data: <searchLink fieldCode="AU" term="%22Kline+C%22">Kline C</searchLink>; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Jain+P%22">Jain P</searchLink>; Division of Neurosurgery, Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Kilburn+L%22">Kilburn L</searchLink>; Department of Hematology and Oncology, Children's National Hospital, Washington, DC.<br /><searchLink fieldCode="AU" term="%22Bonner+ER%22">Bonner ER</searchLink>; Center for Genetic Medicine Research, Children's National Hospital, Washington, DC.; Institute for Biomedical Sciences, The George Washington University School of Medicine and Health Sciences, Washington, DC.<br /><searchLink fieldCode="AU" term="%22Gupta+N%22">Gupta N</searchLink>; Department of Neurological Surgery, University of California, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Crawford+JR%22">Crawford JR</searchLink>; Department of Neuroscience, University of California, San Diego, California.; Rady Children's Hospital San Diego, San Diego, California.<br /><searchLink fieldCode="AU" term="%22Banerjee+A%22">Banerjee A</searchLink>; Department of Neurological Surgery, University of California, San Francisco, California.; Department of Pediatrics, University of California, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Packer+RJ%22">Packer RJ</searchLink>; Center for Neuroscience and Behavioral Medicine, Children's National Hospital, Washington, DC.<br /><searchLink fieldCode="AU" term="%22Villanueva-Meyer+J%22">Villanueva-Meyer J</searchLink>; Department of Radiology and Biomedical Imaging, University of California, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Luks+T%22">Luks T</searchLink>; Department of Radiology and Biomedical Imaging, University of California, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Neurological Surgery, University of California, San Francisco, California.; Department of Epidemiology and Biostatistics, University of California, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Kambhampati+M%22">Kambhampati M</searchLink>; Center for Genetic Medicine Research, Children's National Hospital, Washington, DC.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Neurology, University of California, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Yadavilli+S%22">Yadavilli S</searchLink>; Center for Genetic Medicine Research, Children's National Hospital, Washington, DC.<br /><searchLink fieldCode="AU" term="%22Zhang+B%22">Zhang B</searchLink>; Division of Neurosurgery, Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Gaonkar+KS%22">Gaonkar KS</searchLink>; Division of Neurosurgery, Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Rokita+JL%22">Rokita JL</searchLink>; Division of Neurosurgery, Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Bioinformatics and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Kraya+A%22">Kraya A</searchLink>; Division of Neurosurgery, Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Kuhn+J%22">Kuhn J</searchLink>; College of Pharmacy, University of Texas Health Science Center, San Antonio, Texas.<br /><searchLink fieldCode="AU" term="%22Liang+W%22">Liang W</searchLink>; Translational Genomic Research Institute (TGEN), Phoenix, Arizona.<br /><searchLink fieldCode="AU" term="%22Byron+S%22">Byron S</searchLink>; Translational Genomic Research Institute (TGEN), Phoenix, Arizona.<br /><searchLink fieldCode="AU" term="%22Berens+M%22">Berens M</searchLink>; Translational Genomic Research Institute (TGEN), Phoenix, Arizona.<br /><searchLink fieldCode="AU" term="%22Molinaro+A%22">Molinaro A</searchLink>; Department of Neurological Surgery, University of California, San Francisco, California.; Department of Epidemiology and Biostatistics, University of California, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Prados+M%22">Prados M</searchLink>; Department of Neurological Surgery, University of California, San Francisco, California.<br /><searchLink fieldCode="AU" term="%22Resnick+A%22">Resnick A</searchLink>; Division of Neurosurgery, Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Waszak+SM%22">Waszak SM</searchLink>; Department of Neurology, University of California, San Francisco, California.; Centre for Molecular Medicine Norway (NCMM), Nordic EMBL Partnership, University of Oslo and Oslo University Hospital, Oslo, Norway.; Division of Pediatric and Adolescent Medicine, Department of Pediatric Research, Rikshospitalet, Oslo University Hospital, Oslo, Norway.<br /><searchLink fieldCode="AU" term="%22Nazarian+J%22">Nazarian J</searchLink>; Center for Genetic Medicine Research, Children's National Hospital, Washington, DC.; Institute for Biomedical Sciences, The George Washington University School of Medicine and Health Sciences, Washington, DC.; Department of Oncology, University Children's Hospital Zürich, Zürich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mueller+S%22">Mueller S</searchLink>; Department of Neurological Surgery, University of California, San Francisco, California.; Department of Pediatrics, University of California, San Francisco, California.; Department of Neurology, University of California, San Francisco, California.; Department of Oncology, University Children's Hospital Zürich, Zürich, Switzerland.
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  Data: <searchLink fieldCode="JN" term="%229502500%22">Clinical cancer research : an official journal of the American Association for Cancer Research</searchLink> [Clin Cancer Res] 2022 Sep 15; Vol. 28 (18), pp. 3965-3978.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9502500 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1557-3265 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210780432%22">10780432 </searchLink><i>NLM ISO Abbreviation: </i>Clin Cancer Res <i>Subsets: </i>MEDLINE
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