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Genomic and epigenomic BRCA alterations predict adaptive resistance and response to platinum-based therapy in patients with triple-negative breast and ovarian carcinomas.

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Title: Genomic and epigenomic BRCA alterations predict adaptive resistance and response to platinum-based therapy in patients with triple-negative breast and ovarian carcinomas.
Authors: Menghi F; Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA., Banda K; Division of Medical Oncology, UW Medical Center, Seattle, WA 98195, USA.; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Kumar P; Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA., Straub R; Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA., Dobrolecki L; Lester and Sue Smith Breast Center, Houston, TX 77030, USA., Rodriguez IV; Department of Obstetrics and Gynecology, UW Medical Center, Seattle, WA 98195, USA., Yost SE; Division of Medical Oncology and Therapeutic Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA., Chandok H; Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA., Radke MR; Department of Obstetrics and Gynecology, UW Medical Center, Seattle, WA 98195, USA., Somlo G; Division of Medical Oncology and Therapeutic Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA., Yuan Y; Division of Medical Oncology and Therapeutic Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA., Lewis MT; Departments of Molecular and Cellular Biology and Radiology, Lester and Sue Smith Breast Center, Dan L Duncan Comprehensive Cancer Center, Houston, TX 77030, USA., Swisher EM; Department of Obstetrics and Gynecology, UW Medical Center, Seattle, WA 98195, USA., Liu ET; Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA.
Source: Science translational medicine [Sci Transl Med] 2022 Jul 06; Vol. 14 (652), pp. eabn1926. Date of Electronic Publication: 2022 Jul 06.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Genomic and epigenomic BRCA alterations predict adaptive resistance and response to platinum-based therapy in patients with triple-negative breast and ovarian carcinomas.
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  Data: <searchLink fieldCode="AU" term="%22Menghi+F%22">Menghi F</searchLink>; Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA.<br /><searchLink fieldCode="AU" term="%22Banda+K%22">Banda K</searchLink>; Division of Medical Oncology, UW Medical Center, Seattle, WA 98195, USA.; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.<br /><searchLink fieldCode="AU" term="%22Kumar+P%22">Kumar P</searchLink>; Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA.<br /><searchLink fieldCode="AU" term="%22Straub+R%22">Straub R</searchLink>; Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA.<br /><searchLink fieldCode="AU" term="%22Dobrolecki+L%22">Dobrolecki L</searchLink>; Lester and Sue Smith Breast Center, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Rodriguez+IV%22">Rodriguez IV</searchLink>; Department of Obstetrics and Gynecology, UW Medical Center, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Yost+SE%22">Yost SE</searchLink>; Division of Medical Oncology and Therapeutic Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.<br /><searchLink fieldCode="AU" term="%22Chandok+H%22">Chandok H</searchLink>; Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA.<br /><searchLink fieldCode="AU" term="%22Radke+MR%22">Radke MR</searchLink>; Department of Obstetrics and Gynecology, UW Medical Center, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Somlo+G%22">Somlo G</searchLink>; Division of Medical Oncology and Therapeutic Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.<br /><searchLink fieldCode="AU" term="%22Yuan+Y%22">Yuan Y</searchLink>; Division of Medical Oncology and Therapeutic Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA.<br /><searchLink fieldCode="AU" term="%22Lewis+MT%22">Lewis MT</searchLink>; Departments of Molecular and Cellular Biology and Radiology, Lester and Sue Smith Breast Center, Dan L Duncan Comprehensive Cancer Center, Houston, TX 77030, USA.<br /><searchLink fieldCode="AU" term="%22Swisher+EM%22">Swisher EM</searchLink>; Department of Obstetrics and Gynecology, UW Medical Center, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Liu+ET%22">Liu ET</searchLink>; Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA.
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  Data: <searchLink fieldCode="JN" term="%22101505086%22">Science translational medicine</searchLink> [Sci Transl Med] 2022 Jul 06; Vol. 14 (652), pp. eabn1926. <i>Date of Electronic Publication: </i>2022 Jul 06.
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