Genomic and epigenomic BRCA alterations predict adaptive resistance and response to platinum-based therapy in patients with triple-negative breast and ovarian carcinomas.
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| Title: | Genomic and epigenomic BRCA alterations predict adaptive resistance and response to platinum-based therapy in patients with triple-negative breast and ovarian carcinomas. |
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| Authors: | Menghi F; Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA., Banda K; Division of Medical Oncology, UW Medical Center, Seattle, WA 98195, USA.; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Kumar P; Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA., Straub R; Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA., Dobrolecki L; Lester and Sue Smith Breast Center, Houston, TX 77030, USA., Rodriguez IV; Department of Obstetrics and Gynecology, UW Medical Center, Seattle, WA 98195, USA., Yost SE; Division of Medical Oncology and Therapeutic Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA., Chandok H; Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA., Radke MR; Department of Obstetrics and Gynecology, UW Medical Center, Seattle, WA 98195, USA., Somlo G; Division of Medical Oncology and Therapeutic Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA., Yuan Y; Division of Medical Oncology and Therapeutic Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010, USA., Lewis MT; Departments of Molecular and Cellular Biology and Radiology, Lester and Sue Smith Breast Center, Dan L Duncan Comprehensive Cancer Center, Houston, TX 77030, USA., Swisher EM; Department of Obstetrics and Gynecology, UW Medical Center, Seattle, WA 98195, USA., Liu ET; Jackson Laboratory for Genomic Medicine, Farmington, CT 06030, USA. |
| Source: | Science translational medicine [Sci Transl Med] 2022 Jul 06; Vol. 14 (652), pp. eabn1926. Date of Electronic Publication: 2022 Jul 06. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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