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ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies.

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Title: ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies.
Authors: Low JS; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.; Institute of Microbiology, ETH Zürich, 8093 Zurich, Switzerland., Jerak J; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.; Institute of Microbiology, ETH Zürich, 8093 Zurich, Switzerland., Tortorici MA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., McCallum M; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Pinto D; Humabs BioMed SA (subsidiary of Vir Biotechnology), 6500 Bellinzona, Switzerland., Cassotta A; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland., Foglierini M; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland., Mele F; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland., Abdelnabi R; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium., Weynand B; KU Leuven Department of Imaging and Pathology, Translational Cell and Tissue Research, B-3000 Leuven, Belgium., Noack J; Vir Biotechnology, San Francisco, CA 94158, USA., Montiel-Ruiz M; Vir Biotechnology, San Francisco, CA 94158, USA., Bianchi S; Humabs BioMed SA (subsidiary of Vir Biotechnology), 6500 Bellinzona, Switzerland., Benigni F; Humabs BioMed SA (subsidiary of Vir Biotechnology), 6500 Bellinzona, Switzerland., Sprugasci N; Humabs BioMed SA (subsidiary of Vir Biotechnology), 6500 Bellinzona, Switzerland., Joshi A; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Bowen JE; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Stewart C; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Rexhepaj M; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Walls AC; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, Seattle, WA 98195, USA., Jarrossay D; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland., Morone D; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland., Paparoditis P; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland., Garzoni C; Clinic of Internal Medicine and Infectious Diseases, Clinica Luganese Moncucco, 6900 Lugano, Switzerland., Ferrari P; Faculty of Biomedical Sciences, Università della Svizzera Italiana, 6900 Lugano, Switzerland.; Department of Internal Medicine, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland.; Prince of Wales Hospital Clinical School, University of New South Wales, Sydney, New South Wales 2052, Australia., Ceschi A; Faculty of Biomedical Sciences, Università della Svizzera Italiana, 6900 Lugano, Switzerland.; Division of Clinical Pharmacology and Toxicology, Institute of Pharmacological Sciences of Southern Switzerland, Ente Ospedaliero Cantonale, 6900 Lugano, Switzerland.; Clinical Trial Unit, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland.; Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, 8091 Zurich, Switzerland., Neyts J; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium.; Global Virus Network, Baltimore, MD 21201, USA., Purcell LA; Vir Biotechnology, San Francisco, CA 94158, USA., Snell G; Vir Biotechnology, San Francisco, CA 94158, USA., Corti D; Humabs BioMed SA (subsidiary of Vir Biotechnology), 6500 Bellinzona, Switzerland., Lanzavecchia A; Humabs BioMed SA (subsidiary of Vir Biotechnology), 6500 Bellinzona, Switzerland.; National Institute of Molecular Genetics, 20122 Milano, Italy., Veesler D; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, Seattle, WA 98195, USA., Sallusto F; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.; Institute of Microbiology, ETH Zürich, 8093 Zurich, Switzerland.
Source: Science (New York, N.Y.) [Science] 2022 Aug 12; Vol. 377 (6607), pp. 735-742. Date of Electronic Publication: 2022 Jul 12.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
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  Data: ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies.
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  Data: <searchLink fieldCode="AU" term="%22Low+JS%22">Low JS</searchLink>; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.; Institute of Microbiology, ETH Zürich, 8093 Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Jerak+J%22">Jerak J</searchLink>; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.; Institute of Microbiology, ETH Zürich, 8093 Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Tortorici+MA%22">Tortorici MA</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22McCallum+M%22">McCallum M</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Pinto+D%22">Pinto D</searchLink>; Humabs BioMed SA (subsidiary of Vir Biotechnology), 6500 Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Cassotta+A%22">Cassotta A</searchLink>; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Foglierini+M%22">Foglierini M</searchLink>; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Mele+F%22">Mele F</searchLink>; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Abdelnabi+R%22">Abdelnabi R</searchLink>; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Weynand+B%22">Weynand B</searchLink>; KU Leuven Department of Imaging and Pathology, Translational Cell and Tissue Research, B-3000 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Noack+J%22">Noack J</searchLink>; Vir Biotechnology, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Montiel-Ruiz+M%22">Montiel-Ruiz M</searchLink>; Vir Biotechnology, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Bianchi+S%22">Bianchi S</searchLink>; Humabs BioMed SA (subsidiary of Vir Biotechnology), 6500 Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Benigni+F%22">Benigni F</searchLink>; Humabs BioMed SA (subsidiary of Vir Biotechnology), 6500 Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Sprugasci+N%22">Sprugasci N</searchLink>; Humabs BioMed SA (subsidiary of Vir Biotechnology), 6500 Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Joshi+A%22">Joshi A</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Bowen+JE%22">Bowen JE</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Stewart+C%22">Stewart C</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Rexhepaj+M%22">Rexhepaj M</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Walls+AC%22">Walls AC</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Jarrossay+D%22">Jarrossay D</searchLink>; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Morone+D%22">Morone D</searchLink>; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Paparoditis+P%22">Paparoditis P</searchLink>; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Garzoni+C%22">Garzoni C</searchLink>; Clinic of Internal Medicine and Infectious Diseases, Clinica Luganese Moncucco, 6900 Lugano, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ferrari+P%22">Ferrari P</searchLink>; Faculty of Biomedical Sciences, Università della Svizzera Italiana, 6900 Lugano, Switzerland.; Department of Internal Medicine, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland.; Prince of Wales Hospital Clinical School, University of New South Wales, Sydney, New South Wales 2052, Australia.<br /><searchLink fieldCode="AU" term="%22Ceschi+A%22">Ceschi A</searchLink>; Faculty of Biomedical Sciences, Università della Svizzera Italiana, 6900 Lugano, Switzerland.; Division of Clinical Pharmacology and Toxicology, Institute of Pharmacological Sciences of Southern Switzerland, Ente Ospedaliero Cantonale, 6900 Lugano, Switzerland.; Clinical Trial Unit, Ente Ospedaliero Cantonale, 6500 Bellinzona, Switzerland.; Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, 8091 Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Neyts+J%22">Neyts J</searchLink>; KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium.; Global Virus Network, Baltimore, MD 21201, USA.<br /><searchLink fieldCode="AU" term="%22Purcell+LA%22">Purcell LA</searchLink>; Vir Biotechnology, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Snell+G%22">Snell G</searchLink>; Vir Biotechnology, San Francisco, CA 94158, USA.<br /><searchLink fieldCode="AU" term="%22Corti+D%22">Corti D</searchLink>; Humabs BioMed SA (subsidiary of Vir Biotechnology), 6500 Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lanzavecchia+A%22">Lanzavecchia A</searchLink>; Humabs BioMed SA (subsidiary of Vir Biotechnology), 6500 Bellinzona, Switzerland.; National Institute of Molecular Genetics, 20122 Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Veesler+D%22">Veesler D</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Sallusto+F%22">Sallusto F</searchLink>; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.; Institute of Microbiology, ETH Zürich, 8093 Zurich, Switzerland.
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