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Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses.

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Title: Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses.
Authors: Lan Y; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA yan.lan@emdserono.com kinming.lo@emdserono.com., Yeung TL; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA., Huang H; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA., Wegener AA; Department of Discovery and Development Technologies, Merck Healthcare KGaA, Darmstadt, Germany., Saha S; Department of Translational Medicine, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA., Toister-Achituv M; Department of Discovery and Development Technologies, Merck Healthcare KGaA, Yavne, Israel., Jenkins MH; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA., Chiu LY; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA., Lazorchak A; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA.; Be Biopharma, Cambridge, Massachusetts, USA., Tarcic O; Department of Discovery and Development Technologies, Merck Healthcare KGaA, Yavne, Israel.; CAVOS Biotech, Jerusalem, Israel., Wang H; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA., Qi J; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA., Locke G; Department of Translational Medicine, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA., Kalimi D; Department of Discovery and Development Technologies, Merck Healthcare KGaA, Yavne, Israel., Qin G; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA., Marelli B; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA., Yu H; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA., Gross AW; Department of Discovery Development Technologies, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA., Derner MG; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA., Soloviev M; Department of Discovery Development Technologies, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA., Botte M; LeadXPro AG, Villigen, Switzerland., Sircar A; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA., Ma H; Department of Integrated Supply Chain Operations, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA., Sood VD; Department of Discovery Development Technologies, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA., Zhang D; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA.; D2M Biotherapeutics, Natick, Massachusetts, USA., Jiang F; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA., Lo KM; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA yan.lan@emdserono.com kinming.lo@emdserono.com.
Source: Journal for immunotherapy of cancer [J Immunother Cancer] 2022 Jul; Vol. 10 (7).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Print Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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PubType: Academic Journal
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  Data: Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses.
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  Data: <searchLink fieldCode="AU" term="%22Lan+Y%22">Lan Y</searchLink>; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA yan.lan@emdserono.com kinming.lo@emdserono.com.<br /><searchLink fieldCode="AU" term="%22Yeung+TL%22">Yeung TL</searchLink>; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Huang+H%22">Huang H</searchLink>; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Wegener+AA%22">Wegener AA</searchLink>; Department of Discovery and Development Technologies, Merck Healthcare KGaA, Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22Saha+S%22">Saha S</searchLink>; Department of Translational Medicine, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Toister-Achituv+M%22">Toister-Achituv M</searchLink>; Department of Discovery and Development Technologies, Merck Healthcare KGaA, Yavne, Israel.<br /><searchLink fieldCode="AU" term="%22Jenkins+MH%22">Jenkins MH</searchLink>; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Chiu+LY%22">Chiu LY</searchLink>; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Lazorchak+A%22">Lazorchak A</searchLink>; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA.; Be Biopharma, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Tarcic+O%22">Tarcic O</searchLink>; Department of Discovery and Development Technologies, Merck Healthcare KGaA, Yavne, Israel.; CAVOS Biotech, Jerusalem, Israel.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Qi+J%22">Qi J</searchLink>; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Locke+G%22">Locke G</searchLink>; Department of Translational Medicine, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Kalimi+D%22">Kalimi D</searchLink>; Department of Discovery and Development Technologies, Merck Healthcare KGaA, Yavne, Israel.<br /><searchLink fieldCode="AU" term="%22Qin+G%22">Qin G</searchLink>; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Marelli+B%22">Marelli B</searchLink>; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Yu+H%22">Yu H</searchLink>; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Gross+AW%22">Gross AW</searchLink>; Department of Discovery Development Technologies, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Derner+MG%22">Derner MG</searchLink>; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Soloviev+M%22">Soloviev M</searchLink>; Department of Discovery Development Technologies, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Botte+M%22">Botte M</searchLink>; LeadXPro AG, Villigen, Switzerland.<br /><searchLink fieldCode="AU" term="%22Sircar+A%22">Sircar A</searchLink>; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Ma+H%22">Ma H</searchLink>; Department of Integrated Supply Chain Operations, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Sood+VD%22">Sood VD</searchLink>; Department of Discovery Development Technologies, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+D%22">Zhang D</searchLink>; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA.; D2M Biotherapeutics, Natick, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Jiang+F%22">Jiang F</searchLink>; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Lo+KM%22">Lo KM</searchLink>; Department of TIP OIO, EMD Serono Research and Development Institute, Billerica, Massachusetts, USA yan.lan@emdserono.com kinming.lo@emdserono.com.
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  Data: <searchLink fieldCode="JN" term="%22101620585%22">Journal for immunotherapy of cancer</searchLink> [J Immunother Cancer] 2022 Jul; Vol. 10 (7).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BMJ+Publishing+Group+Ltd%22">BMJ Publishing Group Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101620585 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2051-1426 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220511426%22">20511426 </searchLink><i>NLM ISO Abbreviation: </i>J Immunother Cancer <i>Subsets: </i>MEDLINE
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        Value: 10.1136/jitc-2021-004122
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        Text: English
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      – TitleFull: Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses.
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              Text: 2022 Jul
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