View in EDS

Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions.

Saved in:
Bibliographic Details
Title: Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions.
Authors: Xu G; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Liu Z; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Wang X; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Lu T; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., DesJarlais RL; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Thieu T; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Zhang J; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Devine ZH; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Du F; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Li Q; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Milligan CM; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Shaffer P; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Cedervall PE; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Spurlino JC; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Stratton CF; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Pietrak B; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Szewczuk LM; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Wong V; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Steele RA; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Bruinzeel W; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Chintala M; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Silva J; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Gaul MD; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Macielag MJ; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Nargund R; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2022 Aug 11; Vol. 65 (15), pp. 10419-10440. Date of Electronic Publication: 2022 Jul 21.
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 35862732
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Xu+G%22">Xu G</searchLink>; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.<br /><searchLink fieldCode="AU" term="%22Liu+Z%22">Liu Z</searchLink>; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.<br /><searchLink fieldCode="AU" term="%22Lu+T%22">Lu T</searchLink>; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.<br /><searchLink fieldCode="AU" term="%22DesJarlais+RL%22">DesJarlais RL</searchLink>; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.<br /><searchLink fieldCode="AU" term="%22Thieu+T%22">Thieu T</searchLink>; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.<br /><searchLink fieldCode="AU" term="%22Devine+ZH%22">Devine ZH</searchLink>; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.<br /><searchLink fieldCode="AU" term="%22Du+F%22">Du F</searchLink>; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.<br /><searchLink fieldCode="AU" term="%22Milligan+CM%22">Milligan CM</searchLink>; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.<br /><searchLink fieldCode="AU" term="%22Shaffer+P%22">Shaffer P</searchLink>; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.<br /><searchLink fieldCode="AU" term="%22Cedervall+PE%22">Cedervall PE</searchLink>; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.<br /><searchLink fieldCode="AU" term="%22Spurlino+JC%22">Spurlino JC</searchLink>; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.<br /><searchLink fieldCode="AU" term="%22Stratton+CF%22">Stratton CF</searchLink>; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.<br /><searchLink fieldCode="AU" term="%22Pietrak+B%22">Pietrak B</searchLink>; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.<br /><searchLink fieldCode="AU" term="%22Szewczuk+LM%22">Szewczuk LM</searchLink>; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.<br /><searchLink fieldCode="AU" term="%22Wong+V%22">Wong V</searchLink>; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.<br /><searchLink fieldCode="AU" term="%22Steele+RA%22">Steele RA</searchLink>; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.<br /><searchLink fieldCode="AU" term="%22Bruinzeel+W%22">Bruinzeel W</searchLink>; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.<br /><searchLink fieldCode="AU" term="%22Chintala+M%22">Chintala M</searchLink>; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.<br /><searchLink fieldCode="AU" term="%22Silva+J%22">Silva J</searchLink>; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.<br /><searchLink fieldCode="AU" term="%22Gaul+MD%22">Gaul MD</searchLink>; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.<br /><searchLink fieldCode="AU" term="%22Macielag+MJ%22">Macielag MJ</searchLink>; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.<br /><searchLink fieldCode="AU" term="%22Nargund+R%22">Nargund R</searchLink>; Janssen Research & Development, L.L.C., 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2022 Aug 11; Vol. 65 (15), pp. 10419-10440. <i>Date of Electronic Publication: </i>2022 Jul 21.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=35862732
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1021/acs.jmedchem.2c00442
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 10419
    Titles:
      – TitleFull: Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Xu G
      – PersonEntity:
          Name:
            NameFull: Liu Z
      – PersonEntity:
          Name:
            NameFull: Wang X
      – PersonEntity:
          Name:
            NameFull: Lu T
      – PersonEntity:
          Name:
            NameFull: DesJarlais RL
      – PersonEntity:
          Name:
            NameFull: Thieu T
      – PersonEntity:
          Name:
            NameFull: Zhang J
      – PersonEntity:
          Name:
            NameFull: Devine ZH
      – PersonEntity:
          Name:
            NameFull: Du F
      – PersonEntity:
          Name:
            NameFull: Li Q
      – PersonEntity:
          Name:
            NameFull: Milligan CM
      – PersonEntity:
          Name:
            NameFull: Shaffer P
      – PersonEntity:
          Name:
            NameFull: Cedervall PE
      – PersonEntity:
          Name:
            NameFull: Spurlino JC
      – PersonEntity:
          Name:
            NameFull: Stratton CF
      – PersonEntity:
          Name:
            NameFull: Pietrak B
      – PersonEntity:
          Name:
            NameFull: Szewczuk LM
      – PersonEntity:
          Name:
            NameFull: Wong V
      – PersonEntity:
          Name:
            NameFull: Steele RA
      – PersonEntity:
          Name:
            NameFull: Bruinzeel W
      – PersonEntity:
          Name:
            NameFull: Chintala M
      – PersonEntity:
          Name:
            NameFull: Silva J
      – PersonEntity:
          Name:
            NameFull: Gaul MD
      – PersonEntity:
          Name:
            NameFull: Macielag MJ
      – PersonEntity:
          Name:
            NameFull: Nargund R
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 11
              M: 08
              Text: 2022 Aug 11
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-electronic
              Value: 1520-4804
          Numbering:
            – Type: volume
              Value: 65
            – Type: issue
              Value: 15
          Titles:
            – TitleFull: Journal of medicinal chemistry
              Type: main
ResultId 1