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AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer.

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Title: AXL and Error-Prone DNA Replication Confer Drug Resistance and Offer Strategies to Treat EGFR-Mutant Lung Cancer.
Authors: Noronha A; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Belugali Nataraj N; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Lee JS; Cancer Data Science Lab, NCI, NIH, Bethesda, Maryland.; Next-Gen Medicine Lab, School of Medicine and Department of Artificial Intelligence, Sungkyunkwan University, Suwon, Republic of Korea., Zhitomirsky B; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Oren Y; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts., Oster S; Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel., Lindzen M; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Mukherjee S; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Will R; Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany., Ghosh S; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Simoni-Nieves A; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Verma A; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Chatterjee R; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Borgoni S; Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany., Robinson W; Cancer Data Science Lab, NCI, NIH, Bethesda, Maryland., Sinha S; Cancer Data Science Lab, NCI, NIH, Bethesda, Maryland., Brandis A; Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Kerr DL; Department of Medicine, University of California, San Francisco, California., Wu W; Department of Medicine, University of California, San Francisco, California., Sekar A; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Giri S; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Chung Y; Next-Gen Medicine Lab, School of Medicine and Department of Artificial Intelligence, Sungkyunkwan University, Suwon, Republic of Korea., Drago-Garcia D; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel., Danysh BP; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Lauriola M; Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy., Fiorentino M; Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy., Ardizzoni A; Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.; Medical Oncology IRCCS Azienda Ospedaliero, University of Bologna, Bologna, Italy., Oren M; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Blakely CM; Department of Medicine, University of California, San Francisco, California.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California., Ezike J; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, Massachusetts., Wiemann S; Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany., Parida L; Thomas J. Watson Research Center, IBM Research, Yorktown Heights, New York., Bivona TG; Department of Medicine, University of California, San Francisco, California.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California., Aqeilan RI; Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel., Brugge JS; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts., Regev A; Genentech Inc., South San Francisco, California., Getz G; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Cancer Center and Department of Pathology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts., Ruppin E; Cancer Data Science Lab, NCI, NIH, Bethesda, Maryland., Yarden Y; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
Source: Cancer discovery [Cancer Discov] 2022 Nov 02; Vol. 12 (11), pp. 2666-2683.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Computational and Systems Biology Program, Massachusetts Institute of Technology, Cambridge, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Wiemann+S%22">Wiemann S</searchLink>; Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Parida+L%22">Parida L</searchLink>; Thomas J. 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