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Protein Scaffold-Based Multimerization of Soluble ACE2 Efficiently Blocks SARS-CoV-2 Infection In Vitro and In Vivo.

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Title: Protein Scaffold-Based Multimerization of Soluble ACE2 Efficiently Blocks SARS-CoV-2 Infection In Vitro and In Vivo.
Authors: Kayabolen A; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey., Akcan U; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey., Özturan D; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey., Ulbegi-Polat H; Genetic Engineering and Biotechnology Institute, TUBITAK Marmara Research Center, Kocaeli, 41470, Turkey., Sahin GN; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey., Pinarbasi-Degirmenci N; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey., Bayraktar C; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey., Soyler G; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey., Sarayloo E; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey.; Department of Biotechnology, Beykoz Institute of Life Sciences and Biotechnology (BILSAB), Bezmialem Vakif University, Istanbul, 34820, Turkey., Nurtop E; Koç University Isbank Center for Infectious Diseases (KUISCID), Istanbul, 34010, Turkey., Ozer B; Koç University Isbank Center for Infectious Diseases (KUISCID), Istanbul, 34010, Turkey., Guney-Esken G; Koç University Isbank Center for Infectious Diseases (KUISCID), Istanbul, 34010, Turkey., Barlas T; Koç University Isbank Center for Infectious Diseases (KUISCID), Istanbul, 34010, Turkey., Yildirim IS; Genetic Engineering and Biotechnology Institute, TUBITAK Marmara Research Center, Kocaeli, 41470, Turkey., Dogan O; Koç University Isbank Center for Infectious Diseases (KUISCID), Istanbul, 34010, Turkey.; Koç University School of Medicine, Department of Medical Microbiology, Istanbul, 34010, Turkey., Karahuseyinoglu S; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey.; Koç University School of Medicine, Department of Histology and Embryology, Istanbul, 34450, Türkiye., Lack NA; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey.; Vancouver Prostate Centre, University of British Columbia, Vancouver, BC V6H 3Z6, Canada., Kaya M; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey., Albayrak C; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey.; Department of Biotechnology, Beykoz Institute of Life Sciences and Biotechnology (BILSAB), Bezmialem Vakif University, Istanbul, 34820, Turkey., Can F; Koç University Isbank Center for Infectious Diseases (KUISCID), Istanbul, 34010, Turkey.; Koç University School of Medicine, Department of Medical Microbiology, Istanbul, 34010, Turkey., Solaroglu I; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey.; Department of Basic Sciences, Loma Linda University, Loma Linda, CA, 92354, USA., Bagci-Onder T; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey.
Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2022 Sep; Vol. 9 (27), pp. e2201294. Date of Electronic Publication: 2022 Jul 27.
Publication Type: Journal Article
Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE
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  Data: Protein Scaffold-Based Multimerization of Soluble ACE2 Efficiently Blocks SARS-CoV-2 Infection In Vitro and In Vivo.
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  Data: <searchLink fieldCode="AU" term="%22Kayabolen+A%22">Kayabolen A</searchLink>; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey.<br /><searchLink fieldCode="AU" term="%22Akcan+U%22">Akcan U</searchLink>; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey.<br /><searchLink fieldCode="AU" term="%22Özturan+D%22">Özturan D</searchLink>; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey.<br /><searchLink fieldCode="AU" term="%22Ulbegi-Polat+H%22">Ulbegi-Polat H</searchLink>; Genetic Engineering and Biotechnology Institute, TUBITAK Marmara Research Center, Kocaeli, 41470, Turkey.<br /><searchLink fieldCode="AU" term="%22Sahin+GN%22">Sahin GN</searchLink>; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey.<br /><searchLink fieldCode="AU" term="%22Pinarbasi-Degirmenci+N%22">Pinarbasi-Degirmenci N</searchLink>; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey.<br /><searchLink fieldCode="AU" term="%22Bayraktar+C%22">Bayraktar C</searchLink>; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey.<br /><searchLink fieldCode="AU" term="%22Soyler+G%22">Soyler G</searchLink>; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey.<br /><searchLink fieldCode="AU" term="%22Sarayloo+E%22">Sarayloo E</searchLink>; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey.; Department of Biotechnology, Beykoz Institute of Life Sciences and Biotechnology (BILSAB), Bezmialem Vakif University, Istanbul, 34820, Turkey.<br /><searchLink fieldCode="AU" term="%22Nurtop+E%22">Nurtop E</searchLink>; Koç University Isbank Center for Infectious Diseases (KUISCID), Istanbul, 34010, Turkey.<br /><searchLink fieldCode="AU" term="%22Ozer+B%22">Ozer B</searchLink>; Koç University Isbank Center for Infectious Diseases (KUISCID), Istanbul, 34010, Turkey.<br /><searchLink fieldCode="AU" term="%22Guney-Esken+G%22">Guney-Esken G</searchLink>; Koç University Isbank Center for Infectious Diseases (KUISCID), Istanbul, 34010, Turkey.<br /><searchLink fieldCode="AU" term="%22Barlas+T%22">Barlas T</searchLink>; Koç University Isbank Center for Infectious Diseases (KUISCID), Istanbul, 34010, Turkey.<br /><searchLink fieldCode="AU" term="%22Yildirim+IS%22">Yildirim IS</searchLink>; Genetic Engineering and Biotechnology Institute, TUBITAK Marmara Research Center, Kocaeli, 41470, Turkey.<br /><searchLink fieldCode="AU" term="%22Dogan+O%22">Dogan O</searchLink>; Koç University Isbank Center for Infectious Diseases (KUISCID), Istanbul, 34010, Turkey.; Koç University School of Medicine, Department of Medical Microbiology, Istanbul, 34010, Turkey.<br /><searchLink fieldCode="AU" term="%22Karahuseyinoglu+S%22">Karahuseyinoglu S</searchLink>; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey.; Koç University School of Medicine, Department of Histology and Embryology, Istanbul, 34450, Türkiye.<br /><searchLink fieldCode="AU" term="%22Lack+NA%22">Lack NA</searchLink>; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey.; Vancouver Prostate Centre, University of British Columbia, Vancouver, BC V6H 3Z6, Canada.<br /><searchLink fieldCode="AU" term="%22Kaya+M%22">Kaya M</searchLink>; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey.<br /><searchLink fieldCode="AU" term="%22Albayrak+C%22">Albayrak C</searchLink>; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey.; Department of Biotechnology, Beykoz Institute of Life Sciences and Biotechnology (BILSAB), Bezmialem Vakif University, Istanbul, 34820, Turkey.<br /><searchLink fieldCode="AU" term="%22Can+F%22">Can F</searchLink>; Koç University Isbank Center for Infectious Diseases (KUISCID), Istanbul, 34010, Turkey.; Koç University School of Medicine, Department of Medical Microbiology, Istanbul, 34010, Turkey.<br /><searchLink fieldCode="AU" term="%22Solaroglu+I%22">Solaroglu I</searchLink>; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey.; Department of Basic Sciences, Loma Linda University, Loma Linda, CA, 92354, USA.<br /><searchLink fieldCode="AU" term="%22Bagci-Onder+T%22">Bagci-Onder T</searchLink>; Koç University Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, 34450, Turkey.
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