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Vaccine escape, increased breakthrough and reinfection in infliximab-treated patients with IBD during the Omicron wave of the SARS-CoV-2 pandemic.

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Title: Vaccine escape, increased breakthrough and reinfection in infliximab-treated patients with IBD during the Omicron wave of the SARS-CoV-2 pandemic.
Authors: Kennedy NA; Department of Gastroenterology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Janjua M; Department of Gastroenterology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Chanchlani N; Department of Gastroenterology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Lin S; Department of Gastroenterology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Bewshea C; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Nice R; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK.; Department of Biochemistry, Exeter Clinical Laboratory International, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK., McDonald TJ; Department of Biochemistry, Exeter Clinical Laboratory International, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK., Auckland C; Department of Microbiology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK., Harries LW; Institute of Biomedical and Clinical Sciences, University of Exeter, Exeter, UK., Davies M; Institute of Biomedical and Clinical Sciences, University of Exeter, Exeter, UK., Michell S; College of Life and Environmental Sciences, University of Exeter, Exeter, UK., Kok KB; Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK.; Department of Gastroenterology, Royal London Hospital, Barts Health NHS Trust, The Royal London Hospital, London, UK., Lamb CA; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.; Translational & Clinical Research Institute, Newcastle University Faculty of Medical Sciences, Newcastle upon Tyne, UK., Smith PJ; Department of Gastroenterology, Royal Liverpool Hospital, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK., Hart AL; Department of Gastroenterology, St Mark's Hospital and Academic Institute, London, UK., Pollok RC; Department of Gastroenterology, St George's University Hospitals NHS Foundation Trust, London, UK.; Institute for Infection & Immunity, St George's University of London, London, UK., Lees CW; Department of Gastroenterology, Western General Hospital, Edinburgh, UK.; Institute of Genetic and Molecular Medicine, University of Edinburgh Western General Hospital, Edinburgh, UK., Boyton RJ; Department of Infectious Disease, Imperial College London, London, UK.; Lung Division, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, UK., Altmann DM; Department of Immunology and Inflammation, Imperial College London, London, UK., Sebastian S; IBD Unit, Department of Gastroenterology, Hull University Teaching Hospitals NHS Trust, Hull, UK.; Hull York Medical School, University of Hull, Hull, UK., Powell N; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Gastroenterology, Imperial College Healthcare NHS Trust, London, UK., Goodhand JR; Department of Gastroenterology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK., Ahmad T; Department of Gastroenterology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK tariq.ahmad1@nhs.net.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK.
Source: Gut [Gut] 2023 Feb; Vol. 72 (2), pp. 295-305. Date of Electronic Publication: 2022 Jul 28.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: British Medical Assn Country of Publication: England NLM ID: 2985108R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-3288 (Electronic) Linking ISSN: 00175749 NLM ISO Abbreviation: Gut Subsets: MEDLINE
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  Data: Vaccine escape, increased breakthrough and reinfection in infliximab-treated patients with IBD during the Omicron wave of the SARS-CoV-2 pandemic.
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  Data: <searchLink fieldCode="AU" term="%22Kennedy+NA%22">Kennedy NA</searchLink>; Department of Gastroenterology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Janjua+M%22">Janjua M</searchLink>; Department of Gastroenterology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Chanchlani+N%22">Chanchlani N</searchLink>; Department of Gastroenterology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Lin+S%22">Lin S</searchLink>; Department of Gastroenterology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Bewshea+C%22">Bewshea C</searchLink>; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Nice+R%22">Nice R</searchLink>; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK.; Department of Biochemistry, Exeter Clinical Laboratory International, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22McDonald+TJ%22">McDonald TJ</searchLink>; Department of Biochemistry, Exeter Clinical Laboratory International, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Auckland+C%22">Auckland C</searchLink>; Department of Microbiology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Harries+LW%22">Harries LW</searchLink>; Institute of Biomedical and Clinical Sciences, University of Exeter, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Davies+M%22">Davies M</searchLink>; Institute of Biomedical and Clinical Sciences, University of Exeter, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Michell+S%22">Michell S</searchLink>; College of Life and Environmental Sciences, University of Exeter, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Kok+KB%22">Kok KB</searchLink>; Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine, Queen Mary University of London, London, UK.; Department of Gastroenterology, Royal London Hospital, Barts Health NHS Trust, The Royal London Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Lamb+CA%22">Lamb CA</searchLink>; Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.; Translational & Clinical Research Institute, Newcastle University Faculty of Medical Sciences, Newcastle upon Tyne, UK.<br /><searchLink fieldCode="AU" term="%22Smith+PJ%22">Smith PJ</searchLink>; Department of Gastroenterology, Royal Liverpool Hospital, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Hart+AL%22">Hart AL</searchLink>; Department of Gastroenterology, St Mark's Hospital and Academic Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Pollok+RC%22">Pollok RC</searchLink>; Department of Gastroenterology, St George's University Hospitals NHS Foundation Trust, London, UK.; Institute for Infection & Immunity, St George's University of London, London, UK.<br /><searchLink fieldCode="AU" term="%22Lees+CW%22">Lees CW</searchLink>; Department of Gastroenterology, Western General Hospital, Edinburgh, UK.; Institute of Genetic and Molecular Medicine, University of Edinburgh Western General Hospital, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Boyton+RJ%22">Boyton RJ</searchLink>; Department of Infectious Disease, Imperial College London, London, UK.; Lung Division, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Altmann+DM%22">Altmann DM</searchLink>; Department of Immunology and Inflammation, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Sebastian+S%22">Sebastian S</searchLink>; IBD Unit, Department of Gastroenterology, Hull University Teaching Hospitals NHS Trust, Hull, UK.; Hull York Medical School, University of Hull, Hull, UK.<br /><searchLink fieldCode="AU" term="%22Powell+N%22">Powell N</searchLink>; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Gastroenterology, Imperial College Healthcare NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Goodhand+JR%22">Goodhand JR</searchLink>; Department of Gastroenterology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK.<br /><searchLink fieldCode="AU" term="%22Ahmad+T%22">Ahmad T</searchLink>; Department of Gastroenterology, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK tariq.ahmad1@nhs.net.; Exeter Inflammatory Bowel Disease and Pharmacogenetics Research Group, University of Exeter, Exeter, UK.
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