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Specific CD4+ T Cell Responses to Ancestral SARS-CoV-2 in Children Increase With Age and Show Cross-Reactivity to Beta Variant.

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Title: Specific CD4+ T Cell Responses to Ancestral SARS-CoV-2 in Children Increase With Age and Show Cross-Reactivity to Beta Variant.
Authors: Paul K; University Children's Research - UCR@Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Pediatrics - Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Sibbertsen F; University Children's Research - UCR@Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, United States., Lütgehetmann M; Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; German Center for Infection Research, partner site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany., Barroso M; University Children's Research - UCR@Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Danecka MK; University Children's Research - UCR@Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Glau L; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hecher L; Department of Pediatrics - Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Hermann K; Department of Pediatrics - Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kohl A; Department of Pediatrics - Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Oh J; Department of Pediatrics - Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Schulze Zur Wiesch J; German Center for Infection Research, partner site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.; First Department of Medicine, Division of Infectious Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Sette A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, United States.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA, United States., Tolosa E; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Vettorazzi E; Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Woidy M; University Children's Research - UCR@Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Pediatrics - Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Zapf A; Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Zazara DE; Department of Pediatrics - Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Division for Experimental Feto-Maternal Medicine, Department of Obstetrics and Prenatal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Mir TS; Department of Pediatric Cardiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Muntau AC; Department of Pediatrics - Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Gersting SW; University Children's Research - UCR@Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Dunay GA; University Children's Research - UCR@Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Pediatrics - Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Source: Frontiers in immunology [Front Immunol] 2022 Jul 15; Vol. 13, pp. 867577. Date of Electronic Publication: 2022 Jul 15 (Print Publication: 2022).
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
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  Data: Specific CD4+ T Cell Responses to Ancestral SARS-CoV-2 in Children Increase With Age and Show Cross-Reactivity to Beta Variant.
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  Data: <searchLink fieldCode="AU" term="%22Paul+K%22">Paul K</searchLink>; University Children's Research - UCR@Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Pediatrics - Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Sibbertsen+F%22">Sibbertsen F</searchLink>; University Children's Research - UCR@Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Weiskopf+D%22">Weiskopf D</searchLink>; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, United States.<br /><searchLink fieldCode="AU" term="%22Lütgehetmann+M%22">Lütgehetmann M</searchLink>; Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; German Center for Infection Research, partner site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Barroso+M%22">Barroso M</searchLink>; University Children's Research - UCR@Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Danecka+MK%22">Danecka MK</searchLink>; University Children's Research - UCR@Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Glau+L%22">Glau L</searchLink>; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hecher+L%22">Hecher L</searchLink>; Department of Pediatrics - Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hermann+K%22">Hermann K</searchLink>; Department of Pediatrics - Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kohl+A%22">Kohl A</searchLink>; Department of Pediatrics - Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Oh+J%22">Oh J</searchLink>; Department of Pediatrics - Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schulze+Zur+Wiesch+J%22">Schulze Zur Wiesch J</searchLink>; German Center for Infection Research, partner site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.; First Department of Medicine, Division of Infectious Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Sette+A%22">Sette A</searchLink>; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, United States.; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA, United States.<br /><searchLink fieldCode="AU" term="%22Tolosa+E%22">Tolosa E</searchLink>; Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Vettorazzi+E%22">Vettorazzi E</searchLink>; Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Woidy+M%22">Woidy M</searchLink>; University Children's Research - UCR@Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Pediatrics - Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Zapf+A%22">Zapf A</searchLink>; Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Zazara+DE%22">Zazara DE</searchLink>; Department of Pediatrics - Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Division for Experimental Feto-Maternal Medicine, Department of Obstetrics and Prenatal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Mir+TS%22">Mir TS</searchLink>; Department of Pediatric Cardiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Muntau+AC%22">Muntau AC</searchLink>; Department of Pediatrics - Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Gersting+SW%22">Gersting SW</searchLink>; University Children's Research - UCR@Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Dunay+GA%22">Dunay GA</searchLink>; University Children's Research - UCR@Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Pediatrics - Kinder-UKE, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
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