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Discovery and identification of a novel small molecule BCL-2 inhibitor that binds to the BH4 domain.

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Title: Discovery and identification of a novel small molecule BCL-2 inhibitor that binds to the BH4 domain.
Authors: Zhou JY; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, 210023, China., Yang RR; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China.; University of Chinese Academy of Sciences, No. 19 A Yuquan Road, Beijing, 100049, China.; Shanghai Institute for Advanced Immunochemical Studies, and School of Life Science and Technology, ShanghaiTech University, 393 Huaxiazhong Road, Shanghai, 200031, China., Chang J; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, 210023, China.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China., Song J; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China.; The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China., Fan ZS; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, 210023, China.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China., Zhang YH; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China.; University of Chinese Academy of Sciences, No. 19 A Yuquan Road, Beijing, 100049, China., Lu CH; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, 210023, China.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China., Jiang HL; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, 210023, China. hljiang@simm.ac.cn.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China. hljiang@simm.ac.cn.; University of Chinese Academy of Sciences, No. 19 A Yuquan Road, Beijing, 100049, China. hljiang@simm.ac.cn., Zheng MY; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, 210023, China. myzheng@simm.ac.cn.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China. myzheng@simm.ac.cn.; University of Chinese Academy of Sciences, No. 19 A Yuquan Road, Beijing, 100049, China. myzheng@simm.ac.cn., Zhang SL; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China. slzhang@simm.ac.cn.; University of Chinese Academy of Sciences, No. 19 A Yuquan Road, Beijing, 100049, China. slzhang@simm.ac.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2023 Feb; Vol. 44 (2), pp. 475-485. Date of Electronic Publication: 2022 Aug 02.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery and identification of a novel small molecule BCL-2 inhibitor that binds to the BH4 domain.
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  Data: <searchLink fieldCode="AU" term="%22Zhou+JY%22">Zhou JY</searchLink>; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, 210023, China.<br /><searchLink fieldCode="AU" term="%22Yang+RR%22">Yang RR</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China.; University of Chinese Academy of Sciences, No. 19 A Yuquan Road, Beijing, 100049, China.; Shanghai Institute for Advanced Immunochemical Studies, and School of Life Science and Technology, ShanghaiTech University, 393 Huaxiazhong Road, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Chang+J%22">Chang J</searchLink>; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, 210023, China.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Song+J%22">Song J</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China.; The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.<br /><searchLink fieldCode="AU" term="%22Fan+ZS%22">Fan ZS</searchLink>; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, 210023, China.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Zhang+YH%22">Zhang YH</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China.; University of Chinese Academy of Sciences, No. 19 A Yuquan Road, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Lu+CH%22">Lu CH</searchLink>; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, 210023, China.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Jiang+HL%22">Jiang HL</searchLink>; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, 210023, China. hljiang@simm.ac.cn.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China. hljiang@simm.ac.cn.; University of Chinese Academy of Sciences, No. 19 A Yuquan Road, Beijing, 100049, China. hljiang@simm.ac.cn.<br /><searchLink fieldCode="AU" term="%22Zheng+MY%22">Zheng MY</searchLink>; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, 210023, China. myzheng@simm.ac.cn.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China. myzheng@simm.ac.cn.; University of Chinese Academy of Sciences, No. 19 A Yuquan Road, Beijing, 100049, China. myzheng@simm.ac.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+SL%22">Zhang SL</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China. slzhang@simm.ac.cn.; University of Chinese Academy of Sciences, No. 19 A Yuquan Road, Beijing, 100049, China. slzhang@simm.ac.cn.
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  Data: <searchLink fieldCode="JN" term="%22100956087%22">Acta pharmacologica Sinica</searchLink> [Acta Pharmacol Sin] 2023 Feb; Vol. 44 (2), pp. 475-485. <i>Date of Electronic Publication: </i>2022 Aug 02.
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1038/s41401-022-00936-0
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      – Code: eng
        Text: English
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        StartPage: 475
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      – TitleFull: Discovery and identification of a novel small molecule BCL-2 inhibitor that binds to the BH4 domain.
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              Text: 2023 Feb
              Type: published
              Y: 2023
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