Mcm2 hypomorph leads to acute leukemia or hematopoietic stem cell failure, dependent on genetic context.

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Title: Mcm2 hypomorph leads to acute leukemia or hematopoietic stem cell failure, dependent on genetic context.
Authors: Matsukawa T; Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Yin M; Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Baslan T; Cancer Biology and Genetics Program, Sloan-Kettering Institute, New York, New York, USA., Chung YJ; Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Cao D; Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Bertoli R; Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Zhu YJ; Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Walker RL; Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Freeland A; Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York, USA., Knudsen E; Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York, USA., Lowe SW; Cancer Biology and Genetics Program, Sloan-Kettering Institute, New York, New York, USA.; Howard Hughes Medical Institute, Chevy Chase, Maryland, USA., Meltzer PS; Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Aplan PD; Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Source: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2022 Sep; Vol. 36 (9), pp. e22430.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Intramural
Journal Info: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:1530-6860
DOI:10.1096/fj.202200061RR