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Transcriptional variability accelerates preleukemia by cell diversification and perturbation of protein synthesis.

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Title: Transcriptional variability accelerates preleukemia by cell diversification and perturbation of protein synthesis.
Authors: Gupta S; Department of Genetics, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Dovey OM; Wellcome Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK., Domingues AF; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Cyran OW; Department of Haematology, University of Cambridge, Cambridge, UK., Cash CM; College of Health, Medicine and Life Sciences - Division of Biosciences, Brunel University London, Uxbridge, UK., Giotopoulos G; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Rak J; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Cooper J; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Gozdecka M; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Dijkhuis L; College of Health, Medicine and Life Sciences - Division of Biosciences, Brunel University London, Uxbridge, UK., Asby RJ; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Al-Jabery N; College of Health, Medicine and Life Sciences - Division of Biosciences, Brunel University London, Uxbridge, UK., Hernandez-Hernandez V; College of Health, Medicine and Life Sciences - Division of Biosciences, Brunel University London, Uxbridge, UK.; Centre for Genome Engineering and Maintenance, Brunel University London, Uxbridge, UB8 3PH, UK., Prabakaran S; NonExomics Inc., Boston, MA, USA., Huntly BJ; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Vassiliou GS; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Pina C; College of Health, Medicine and Life Sciences - Division of Biosciences, Brunel University London, Uxbridge, UK.; Centre for Genome Engineering and Maintenance, Brunel University London, Uxbridge, UB8 3PH, UK.
Source: Science advances [Sci Adv] 2022 Aug 05; Vol. 8 (31), pp. eabn4886. Date of Electronic Publication: 2022 Aug 03.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Gupta+S%22">Gupta S</searchLink>; Department of Genetics, University of Cambridge, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Dovey+OM%22">Dovey OM</searchLink>; Wellcome Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Domingues+AF%22">Domingues AF</searchLink>; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Cyran+OW%22">Cyran OW</searchLink>; Department of Haematology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Cash+CM%22">Cash CM</searchLink>; College of Health, Medicine and Life Sciences - Division of Biosciences, Brunel University London, Uxbridge, UK.<br /><searchLink fieldCode="AU" term="%22Giotopoulos+G%22">Giotopoulos G</searchLink>; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Rak+J%22">Rak J</searchLink>; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Cooper+J%22">Cooper J</searchLink>; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Gozdecka+M%22">Gozdecka M</searchLink>; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Dijkhuis+L%22">Dijkhuis L</searchLink>; College of Health, Medicine and Life Sciences - Division of Biosciences, Brunel University London, Uxbridge, UK.<br /><searchLink fieldCode="AU" term="%22Asby+RJ%22">Asby RJ</searchLink>; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Al-Jabery+N%22">Al-Jabery N</searchLink>; College of Health, Medicine and Life Sciences - Division of Biosciences, Brunel University London, Uxbridge, UK.<br /><searchLink fieldCode="AU" term="%22Hernandez-Hernandez+V%22">Hernandez-Hernandez V</searchLink>; College of Health, Medicine and Life Sciences - Division of Biosciences, Brunel University London, Uxbridge, UK.; Centre for Genome Engineering and Maintenance, Brunel University London, Uxbridge, UB8 3PH, UK.<br /><searchLink fieldCode="AU" term="%22Prabakaran+S%22">Prabakaran S</searchLink>; NonExomics Inc., Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Huntly+BJ%22">Huntly BJ</searchLink>; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Vassiliou+GS%22">Vassiliou GS</searchLink>; Department of Haematology, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.; Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Pina+C%22">Pina C</searchLink>; College of Health, Medicine and Life Sciences - Division of Biosciences, Brunel University London, Uxbridge, UK.; Centre for Genome Engineering and Maintenance, Brunel University London, Uxbridge, UB8 3PH, UK.
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