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Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors.

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Title: Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors.
Authors: Reinbold R; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK., Hvinden IC; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK., Rabe P; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK., Herold RA; Department of Chemistry, University of Oxford, Oxford, OX1 3QR, UK., Finch A; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Wood J; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Morgan M; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Staudt M; Institute of Pharmaceutical Sciences, University of Freiburg, 79104, Freiburg, Germany., Clifton IJ; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK., Armstrong FA; Department of Chemistry, University of Oxford, Oxford, OX1 3QR, UK., McCullagh JSO; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK., Redmond J; GlaxoSmithKline, Gunnels Wood Rd, Stevenage, SG1 2NY, UK., Bardella C; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK., Abboud MI; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK. martine.abboud@lau.edu.; Department of Natural Sciences, Lebanese American University, Byblos/Beirut, Lebanon. martine.abboud@lau.edu., Schofield CJ; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK. christopher.schofield@chem.ox.ac.uk.
Source: Nature communications [Nat Commun] 2022 Aug 15; Vol. 13 (1), pp. 4785. Date of Electronic Publication: 2022 Aug 15.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22Reinbold+R%22">Reinbold R</searchLink>; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK.<br /><searchLink fieldCode="AU" term="%22Hvinden+IC%22">Hvinden IC</searchLink>; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK.<br /><searchLink fieldCode="AU" term="%22Rabe+P%22">Rabe P</searchLink>; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK.<br /><searchLink fieldCode="AU" term="%22Herold+RA%22">Herold RA</searchLink>; Department of Chemistry, University of Oxford, Oxford, OX1 3QR, UK.<br /><searchLink fieldCode="AU" term="%22Finch+A%22">Finch A</searchLink>; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Wood+J%22">Wood J</searchLink>; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Morgan+M%22">Morgan M</searchLink>; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Staudt+M%22">Staudt M</searchLink>; Institute of Pharmaceutical Sciences, University of Freiburg, 79104, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Clifton+IJ%22">Clifton IJ</searchLink>; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK.<br /><searchLink fieldCode="AU" term="%22Armstrong+FA%22">Armstrong FA</searchLink>; Department of Chemistry, University of Oxford, Oxford, OX1 3QR, UK.<br /><searchLink fieldCode="AU" term="%22McCullagh+JSO%22">McCullagh JSO</searchLink>; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK.<br /><searchLink fieldCode="AU" term="%22Redmond+J%22">Redmond J</searchLink>; GlaxoSmithKline, Gunnels Wood Rd, Stevenage, SG1 2NY, UK.<br /><searchLink fieldCode="AU" term="%22Bardella+C%22">Bardella C</searchLink>; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.<br /><searchLink fieldCode="AU" term="%22Abboud+MI%22">Abboud MI</searchLink>; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK. martine.abboud@lau.edu.; Department of Natural Sciences, Lebanese American University, Byblos/Beirut, Lebanon. martine.abboud@lau.edu.<br /><searchLink fieldCode="AU" term="%22Schofield+CJ%22">Schofield CJ</searchLink>; Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield, Oxford, OX1 3TA, UK. christopher.schofield@chem.ox.ac.uk.
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