A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues.
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| Title: | A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues. |
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| Authors: | Saul D; Division of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA. saul.dominik@mayo.edu.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA. saul.dominik@mayo.edu.; Department of Trauma, Orthopedics and Reconstructive Surgery, Georg-August-University of Goettingen, Goettingen, Germany. saul.dominik@mayo.edu., Kosinsky RL; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, 55905, USA., Atkinson EJ; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Doolittle ML; Division of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA., Zhang X; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., LeBrasseur NK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Pignolo RJ; Division of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Robbins PD; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., Niedernhofer LJ; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., Ikeno Y; Department of Pathology, University of Texas Health, San Antonio, TX, USA., Jurk D; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Passos JF; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Hickson LJ; Division of Nephrology and Hypertension, Mayo Clinic, Jacksonville, FL, USA., Xue A; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA., Monroe DG; Division of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA., Tchkonia T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Kirkland JL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Farr JN; Division of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA. farr.joshua@mayo.edu.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA. farr.joshua@mayo.edu.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. farr.joshua@mayo.edu., Khosla S; Division of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA. khosla.sundeep@mayo.edu.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA. khosla.sundeep@mayo.edu.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. khosla.sundeep@mayo.edu. |
| Source: | Nature communications [Nat Commun] 2022 Aug 16; Vol. 13 (1), pp. 4827. Date of Electronic Publication: 2022 Aug 16. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-022-32552-1 |
