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A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues.

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Title: A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues.
Authors: Saul D; Division of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA. saul.dominik@mayo.edu.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA. saul.dominik@mayo.edu.; Department of Trauma, Orthopedics and Reconstructive Surgery, Georg-August-University of Goettingen, Goettingen, Germany. saul.dominik@mayo.edu., Kosinsky RL; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, 55905, USA., Atkinson EJ; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA., Doolittle ML; Division of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA., Zhang X; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., LeBrasseur NK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Pignolo RJ; Division of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Robbins PD; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., Niedernhofer LJ; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA., Ikeno Y; Department of Pathology, University of Texas Health, San Antonio, TX, USA., Jurk D; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Passos JF; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Hickson LJ; Division of Nephrology and Hypertension, Mayo Clinic, Jacksonville, FL, USA., Xue A; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA., Monroe DG; Division of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA., Tchkonia T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Kirkland JL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA., Farr JN; Division of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA. farr.joshua@mayo.edu.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA. farr.joshua@mayo.edu.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. farr.joshua@mayo.edu., Khosla S; Division of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA. khosla.sundeep@mayo.edu.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA. khosla.sundeep@mayo.edu.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. khosla.sundeep@mayo.edu.
Source: Nature communications [Nat Commun] 2022 Aug 16; Vol. 13 (1), pp. 4827. Date of Electronic Publication: 2022 Aug 16.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Saul+D%22">Saul D</searchLink>; Division of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA. saul.dominik@mayo.edu.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA. saul.dominik@mayo.edu.; Department of Trauma, Orthopedics and Reconstructive Surgery, Georg-August-University of Goettingen, Goettingen, Germany. saul.dominik@mayo.edu.<br /><searchLink fieldCode="AU" term="%22Kosinsky+RL%22">Kosinsky RL</searchLink>; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Atkinson+EJ%22">Atkinson EJ</searchLink>; Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Doolittle+ML%22">Doolittle ML</searchLink>; Division of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22LeBrasseur+NK%22">LeBrasseur NK</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Pignolo+RJ%22">Pignolo RJ</searchLink>; Division of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Robbins+PD%22">Robbins PD</searchLink>; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Niedernhofer+LJ%22">Niedernhofer LJ</searchLink>; Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Ikeno+Y%22">Ikeno Y</searchLink>; Department of Pathology, University of Texas Health, San Antonio, TX, USA.<br /><searchLink fieldCode="AU" term="%22Jurk+D%22">Jurk D</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Passos+JF%22">Passos JF</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Hickson+LJ%22">Hickson LJ</searchLink>; Division of Nephrology and Hypertension, Mayo Clinic, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Xue+A%22">Xue A</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Monroe+DG%22">Monroe DG</searchLink>; Division of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.<br /><searchLink fieldCode="AU" term="%22Tchkonia+T%22">Tchkonia T</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Kirkland+JL%22">Kirkland JL</searchLink>; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.<br /><searchLink fieldCode="AU" term="%22Farr+JN%22">Farr JN</searchLink>; Division of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA. farr.joshua@mayo.edu.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA. farr.joshua@mayo.edu.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. farr.joshua@mayo.edu.<br /><searchLink fieldCode="AU" term="%22Khosla+S%22">Khosla S</searchLink>; Division of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA. khosla.sundeep@mayo.edu.; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA. khosla.sundeep@mayo.edu.; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA. khosla.sundeep@mayo.edu.
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