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Durable protection against the SARS-CoV-2 Omicron variant is induced by an adjuvanted subunit vaccine.

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Title: Durable protection against the SARS-CoV-2 Omicron variant is induced by an adjuvanted subunit vaccine.
Authors: Arunachalam PS; Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA 94305, USA., Feng Y; Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA 94305, USA., Ashraf U; Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA 94305, USA., Hu M; Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA 94305, USA., Walls AC; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA., Edara VV; Department of Pediatrics, Emory Vaccine Center, Emory National Primate Research Center, and Emory University School of Medicine, Atlanta, GA 30329, USA., Zarnitsyna VI; Department of Microbiology and Immunology, Emory University, Atlanta, GA 30329, USA., Aye PP; Tulane National Primate Research Center, Covington, LA 70433, USA., Golden N; Tulane National Primate Research Center, Covington, LA 70433, USA., Miranda MC; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Green KWM; Tulane National Primate Research Center, Covington, LA 70433, USA., Threeton BM; Tulane National Primate Research Center, Covington, LA 70433, USA., Maness NJ; Tulane National Primate Research Center, Covington, LA 70433, USA., Beddingfield BJ; Tulane National Primate Research Center, Covington, LA 70433, USA., Bohm RP; Tulane National Primate Research Center, Covington, LA 70433, USA., Scheuermann SE; Tulane National Primate Research Center, Covington, LA 70433, USA., Goff K; Tulane National Primate Research Center, Covington, LA 70433, USA., Dufour J; Tulane National Primate Research Center, Covington, LA 70433, USA., Russell-Lodrigue K; Tulane National Primate Research Center, Covington, LA 70433, USA., Kepl E; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Fiala B; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Wrenn S; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Ravichandran R; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Ellis D; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Carter L; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Rogers K; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA 70560, USA., Shirreff LM; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA 70560, USA., Ferrell DE; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA 70560, USA., Deb Adhikary NR; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA 70560, USA., Fontenot J; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA 70560, USA., Hammond HL; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Frieman M; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Grifoni A; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, CA 92037, USA., Sette A; Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, La Jolla, CA 92037, USA.; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA., O'Hagan DT; GSK, Rockville, MD 20850, USA., Van Der Most R; GSK, Rixensart 1330, Belgium., Rappuoli R; GSK, Siena 53100, Italy., Villinger F; New Iberia Research Center, University of Louisiana at Lafayette, New Iberia, LA 70560, USA., Kleanthous H; Bill and Melinda Gates Foundation, Seattle, WA 98109, USA., Rappaport J; Tulane National Primate Research Center, Covington, LA 70433, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA., Suthar MS; Department of Pediatrics, Emory Vaccine Center, Emory National Primate Research Center, and Emory University School of Medicine, Atlanta, GA 30329, USA., Veesler D; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA., Wang TT; Department of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA 94305, USA.; Department of Microbiology and Immunology, School of Medicine, Stanford University, Stanford, CA 94305, USA., King NP; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98195, USA., Pulendran B; Institute for Immunity, Transplantation and Infection, School of Medicine, Stanford University, Stanford, CA 94305, USA.; Department of Microbiology and Immunology, School of Medicine, Stanford University, Stanford, CA 94305, USA.; Department of Pathology, School of Medicine, Stanford University, Stanford, CA 94305, USA.
Source: Science translational medicine [Sci Transl Med] 2022 Aug 17; Vol. 14 (658), pp. eabq4130. Date of Electronic Publication: 2022 Aug 17.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1946-6242
DOI:10.1126/scitranslmed.abq4130