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Rare coding variation provides insight into the genetic architecture and phenotypic context of autism.

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Title: Rare coding variation provides insight into the genetic architecture and phenotypic context of autism.
Authors: Fu JM; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Satterstrom FK; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Peng M; Department of Statistics and Data Science, Carnegie Mellon University, Pittsburgh, PA, USA., Brand H; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Pediatric Surgical Research Laboratories, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA., Collins RL; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA, USA., Dong S; Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA., Wamsley B; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Klei L; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA., Wang L; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA, USA., Hao SP; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Pediatric Surgical Research Laboratories, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA., Stevens CR; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Cusick C; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Babadi M; Data Sciences Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Banks E; Data Sciences Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Collins B; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Dodge S; Genomics Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Gabriel SB; Genomics Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Gauthier L; Data Sciences Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lee SK; Data Sciences Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Liang L; Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA., Ljungdahl A; Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA., Mahjani B; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Sloofman L; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Smirnov AN; Data Sciences Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Barbosa M; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Betancur C; Sorbonne Université, INSERM, CNRS, Neuroscience Paris Seine, Institut de Biologie Paris Seine, Paris, France., Brusco A; Department of Medical Sciences, University of Torino, Turin, Italy.; Medical Genetics Unit, 'Città della Salute e della Scienza' University Hospital, Turin, Italy., Chung BHY; Department of Pediatrics and Adolescent Medicine, Duchess of Kent Children's Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China., Cook EH; Institute for Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA., Cuccaro ML; The John P Hussman Institute for Human Genomics, The University of Miami Miller School of Medicine, Miami, FL, USA., Domenici E; Department of Cellular, Computational and Integrative Biology, , University of Trento, Trento, Italy., Ferrero GB; Department of Public Health and Pediatrics, University of Torino, Turin, Italy., Gargus JJ; Center for Autism Research and Translation, University of California Irvine, Irvine, CA, USA., Herman GE; The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA., Hertz-Picciotto I; MIND (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California Davis, Davis, CA, USA., Maciel P; Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga, Portugal., Manoach DS; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Passos-Bueno MR; Centro de Pesquisas sobre o Genoma Humano e Células tronco, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil., Persico AM; Interdepartmental Program 'Autism 0-90', 'Gaetano Martino' University Hospital, University of Messina, Messina, Italy., Renieri A; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, Italy.; Medical Genetics, , University of Siena, Siena, Italy.; Genetica Medica, Azienda Ospedaliera Universitaria Senese, Siena, Italy., Sutcliffe JS; Department of Molecular Physiology & Biophysics and Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, TN, USA., Tassone F; MIND (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California Davis, Davis, CA, USA.; Department of Biochemistry and Molecular Medicine, University of California Davis, School of Medicine, Sacramento, CA, USA., Trabetti E; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics, University of Verona, Verona, Italy., Campos G; Centro de Pesquisas sobre o Genoma Humano e Células tronco, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil., Cardaropoli S; Department of Public Health and Pediatrics, University of Torino, Turin, Italy., Carli D; Department of Public Health and Pediatrics, University of Torino, Turin, Italy., Chan MCY; Department of Pediatrics and Adolescent Medicine, Duchess of Kent Children's Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China., Fallerini C; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, Italy.; Medical Genetics, , University of Siena, Siena, Italy., Giorgio E; Department of Medical Sciences, University of Torino, Turin, Italy., Girardi AC; Centro de Pesquisas sobre o Genoma Humano e Células tronco, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil., Hansen-Kiss E; Department of Diagnostic and Biomedical Sciences, University of Texas Health Science Center at Houston, School of Dentistry, Houston, TX, USA., Lee SL; Department of Pediatrics and Adolescent Medicine, Duchess of Kent Children's Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China., Lintas C; Service for Neurodevelopmental Disorders, University Campus Bio-medico of Rome, Rome, Italy., Ludena Y; MIND (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California Davis, Davis, CA, USA., Nguyen R; Center for Autism Research and Translation, University of California Irvine, Irvine, CA, USA., Pavinato L; Department of Medical Sciences, University of Torino, Turin, Italy., Pericak-Vance M; The John P Hussman Institute for Human Genomics, The University of Miami Miller School of Medicine, Miami, FL, USA., Pessah IN; MIND (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California Davis, Davis, CA, USA.; Department of Molecular Biosciences, University of California Davis, School of Veterinary Medicine, Davis, CA, USA., Schmidt RJ; MIND (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California Davis, Davis, CA, USA., Smith M; Center for Autism Research and Translation, University of California Irvine, Irvine, CA, USA., Costa CIS; Centro de Pesquisas sobre o Genoma Humano e Células tronco, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil., Trajkova S; Department of Medical Sciences, University of Torino, Turin, Italy., Wang JYT; Centro de Pesquisas sobre o Genoma Humano e Células tronco, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil., Yu MHC; Department of Pediatrics and Adolescent Medicine, Duchess of Kent Children's Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China., Cutler DJ; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA., De Rubeis S; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Buxbaum JD; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu., Daly MJ; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. mjdaly@atgu.mgh.harvard.edu.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. mjdaly@atgu.mgh.harvard.edu.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. mjdaly@atgu.mgh.harvard.edu.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. mjdaly@atgu.mgh.harvard.edu.; Harvard Medical School, Boston, MA, USA. mjdaly@atgu.mgh.harvard.edu.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. mjdaly@atgu.mgh.harvard.edu., Devlin B; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. devlinbj@upmc.edu., Roeder K; Department of Statistics and Data Science, Carnegie Mellon University, Pittsburgh, PA, USA. roeder@andrew.cmu.edu.; Computational Biology Department, Carnegie Mellon University, Pittsburgh, PA, USA. roeder@andrew.cmu.edu., Sanders SJ; Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA. Stephan.Sanders@ucsf.edu., Talkowski ME; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. MTALKOWSKI@mgh.harvard.edu.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. MTALKOWSKI@mgh.harvard.edu.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. MTALKOWSKI@mgh.harvard.edu.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. MTALKOWSKI@mgh.harvard.edu.; Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA, USA. MTALKOWSKI@mgh.harvard.edu.
Corporate Authors: Autism Sequencing Consortium (ASC), Broad Institute Center for Common Disease Genomics (Broad-CCDG), iPSYCH-BROAD Consortium
Source: Nature genetics [Nat Genet] 2022 Sep; Vol. 54 (9), pp. 1320-1331. Date of Electronic Publication: 2022 Aug 18.
Publication Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
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  Data: Rare coding variation provides insight into the genetic architecture and phenotypic context of autism.
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  Label: Authors
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  Data: <searchLink fieldCode="AU" term="%22Fu+JM%22">Fu JM</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Satterstrom+FK%22">Satterstrom FK</searchLink>; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Peng+M%22">Peng M</searchLink>; Department of Statistics and Data Science, Carnegie Mellon University, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Brand+H%22">Brand H</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Pediatric Surgical Research Laboratories, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Collins+RL%22">Collins RL</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dong+S%22">Dong S</searchLink>; Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wamsley+B%22">Wamsley B</searchLink>; Program in Neurogenetics, Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Klei+L%22">Klei L</searchLink>; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hao+SP%22">Hao SP</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Pediatric Surgical Research Laboratories, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Stevens+CR%22">Stevens CR</searchLink>; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Cusick+C%22">Cusick C</searchLink>; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Babadi+M%22">Babadi M</searchLink>; Data Sciences Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Banks+E%22">Banks E</searchLink>; Data Sciences Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Collins+B%22">Collins B</searchLink>; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Dodge+S%22">Dodge S</searchLink>; Genomics Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gabriel+SB%22">Gabriel SB</searchLink>; Genomics Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gauthier+L%22">Gauthier L</searchLink>; Data Sciences Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lee+SK%22">Lee SK</searchLink>; Data Sciences Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Liang+L%22">Liang L</searchLink>; Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ljungdahl+A%22">Ljungdahl A</searchLink>; Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mahjani+B%22">Mahjani B</searchLink>; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22Sloofman+L%22">Sloofman L</searchLink>; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Smirnov+AN%22">Smirnov AN</searchLink>; Data Sciences Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Barbosa+M%22">Barbosa M</searchLink>; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Betancur+C%22">Betancur C</searchLink>; Sorbonne Université, INSERM, CNRS, Neuroscience Paris Seine, Institut de Biologie Paris Seine, Paris, France.<br /><searchLink fieldCode="AU" term="%22Brusco+A%22">Brusco A</searchLink>; Department of Medical Sciences, University of Torino, Turin, Italy.; Medical Genetics Unit, 'Città della Salute e della Scienza' University Hospital, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Chung+BHY%22">Chung BHY</searchLink>; Department of Pediatrics and Adolescent Medicine, Duchess of Kent Children's Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Cook+EH%22">Cook EH</searchLink>; Institute for Juvenile Research, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Cuccaro+ML%22">Cuccaro ML</searchLink>; The John P Hussman Institute for Human Genomics, The University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Domenici+E%22">Domenici E</searchLink>; Department of Cellular, Computational and Integrative Biology, , University of Trento, Trento, Italy.<br /><searchLink fieldCode="AU" term="%22Ferrero+GB%22">Ferrero GB</searchLink>; Department of Public Health and Pediatrics, University of Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Gargus+JJ%22">Gargus JJ</searchLink>; Center for Autism Research and Translation, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Herman+GE%22">Herman GE</searchLink>; The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.<br /><searchLink fieldCode="AU" term="%22Hertz-Picciotto+I%22">Hertz-Picciotto I</searchLink>; MIND (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California Davis, Davis, CA, USA.<br /><searchLink fieldCode="AU" term="%22Maciel+P%22">Maciel P</searchLink>; Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga, Portugal.<br /><searchLink fieldCode="AU" term="%22Manoach+DS%22">Manoach DS</searchLink>; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Passos-Bueno+MR%22">Passos-Bueno MR</searchLink>; Centro de Pesquisas sobre o Genoma Humano e Células tronco, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Persico+AM%22">Persico AM</searchLink>; Interdepartmental Program 'Autism 0-90', 'Gaetano Martino' University Hospital, University of Messina, Messina, Italy.<br /><searchLink fieldCode="AU" term="%22Renieri+A%22">Renieri A</searchLink>; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, Italy.; Medical Genetics, , University of Siena, Siena, Italy.; Genetica Medica, Azienda Ospedaliera Universitaria Senese, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Sutcliffe+JS%22">Sutcliffe JS</searchLink>; Department of Molecular Physiology & Biophysics and Psychiatry, Vanderbilt University School of Medicine, Nashville, TN, USA.; Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Tassone+F%22">Tassone F</searchLink>; MIND (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California Davis, Davis, CA, USA.; Department of Biochemistry and Molecular Medicine, University of California Davis, School of Medicine, Sacramento, CA, USA.<br /><searchLink fieldCode="AU" term="%22Trabetti+E%22">Trabetti E</searchLink>; Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biology and Genetics, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Campos+G%22">Campos G</searchLink>; Centro de Pesquisas sobre o Genoma Humano e Células tronco, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Cardaropoli+S%22">Cardaropoli S</searchLink>; Department of Public Health and Pediatrics, University of Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Carli+D%22">Carli D</searchLink>; Department of Public Health and Pediatrics, University of Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Chan+MCY%22">Chan MCY</searchLink>; Department of Pediatrics and Adolescent Medicine, Duchess of Kent Children's Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Fallerini+C%22">Fallerini C</searchLink>; Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, Italy.; Medical Genetics, , University of Siena, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Giorgio+E%22">Giorgio E</searchLink>; Department of Medical Sciences, University of Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Girardi+AC%22">Girardi AC</searchLink>; Centro de Pesquisas sobre o Genoma Humano e Células tronco, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Hansen-Kiss+E%22">Hansen-Kiss E</searchLink>; Department of Diagnostic and Biomedical Sciences, University of Texas Health Science Center at Houston, School of Dentistry, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Lee+SL%22">Lee SL</searchLink>; Department of Pediatrics and Adolescent Medicine, Duchess of Kent Children's Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Lintas+C%22">Lintas C</searchLink>; Service for Neurodevelopmental Disorders, University Campus Bio-medico of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Ludena+Y%22">Ludena Y</searchLink>; MIND (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California Davis, Davis, CA, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+R%22">Nguyen R</searchLink>; Center for Autism Research and Translation, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Pavinato+L%22">Pavinato L</searchLink>; Department of Medical Sciences, University of Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Pericak-Vance+M%22">Pericak-Vance M</searchLink>; The John P Hussman Institute for Human Genomics, The University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Pessah+IN%22">Pessah IN</searchLink>; MIND (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California Davis, Davis, CA, USA.; Department of Molecular Biosciences, University of California Davis, School of Veterinary Medicine, Davis, CA, USA.<br /><searchLink fieldCode="AU" term="%22Schmidt+RJ%22">Schmidt RJ</searchLink>; MIND (Medical Investigation of Neurodevelopmental Disorders) Institute, University of California Davis, Davis, CA, USA.<br /><searchLink fieldCode="AU" term="%22Smith+M%22">Smith M</searchLink>; Center for Autism Research and Translation, University of California Irvine, Irvine, CA, USA.<br /><searchLink fieldCode="AU" term="%22Costa+CIS%22">Costa CIS</searchLink>; Centro de Pesquisas sobre o Genoma Humano e Células tronco, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Trajkova+S%22">Trajkova S</searchLink>; Department of Medical Sciences, University of Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Wang+JYT%22">Wang JYT</searchLink>; Centro de Pesquisas sobre o Genoma Humano e Células tronco, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Yu+MHC%22">Yu MHC</searchLink>; Department of Pediatrics and Adolescent Medicine, Duchess of Kent Children's Hospital, The University of Hong Kong, Hong Kong Special Administrative Region, China.<br /><searchLink fieldCode="AU" term="%22Cutler+DJ%22">Cutler DJ</searchLink>; Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22De+Rubeis+S%22">De Rubeis S</searchLink>; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Buxbaum+JD%22">Buxbaum JD</searchLink>; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. joseph.buxbaum@mssm.edu.<br /><searchLink fieldCode="AU" term="%22Daly+MJ%22">Daly MJ</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. mjdaly@atgu.mgh.harvard.edu.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. mjdaly@atgu.mgh.harvard.edu.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. mjdaly@atgu.mgh.harvard.edu.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. mjdaly@atgu.mgh.harvard.edu.; Harvard Medical School, Boston, MA, USA. mjdaly@atgu.mgh.harvard.edu.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. mjdaly@atgu.mgh.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Devlin+B%22">Devlin B</searchLink>; Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. devlinbj@upmc.edu.<br /><searchLink fieldCode="AU" term="%22Roeder+K%22">Roeder K</searchLink>; Department of Statistics and Data Science, Carnegie Mellon University, Pittsburgh, PA, USA. roeder@andrew.cmu.edu.; Computational Biology Department, Carnegie Mellon University, Pittsburgh, PA, USA. roeder@andrew.cmu.edu.<br /><searchLink fieldCode="AU" term="%22Sanders+SJ%22">Sanders SJ</searchLink>; Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA. Stephan.Sanders@ucsf.edu.<br /><searchLink fieldCode="AU" term="%22Talkowski+ME%22">Talkowski ME</searchLink>; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. MTALKOWSKI@mgh.harvard.edu.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. MTALKOWSKI@mgh.harvard.edu.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. MTALKOWSKI@mgh.harvard.edu.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. MTALKOWSKI@mgh.harvard.edu.; Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA, USA. MTALKOWSKI@mgh.harvard.edu.
– Name: AuthorCorporate
  Label: Corporate Authors
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  Data: <searchLink fieldCode="CA" term="%22Autism+Sequencing+Consortium+%28ASC%29%22">Autism Sequencing Consortium (ASC)</searchLink><br /><searchLink fieldCode="CA" term="%22Broad+Institute+Center+for+Common+Disease+Genomics+%28Broad-CCDG%29%22">Broad Institute Center for Common Disease Genomics (Broad-CCDG)</searchLink><br /><searchLink fieldCode="CA" term="%22iPSYCH-BROAD+Consortium%22">iPSYCH-BROAD Consortium</searchLink>
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  Data: <searchLink fieldCode="JN" term="%229216904%22">Nature genetics</searchLink> [Nat Genet] 2022 Sep; Vol. 54 (9), pp. 1320-1331. <i>Date of Electronic Publication: </i>2022 Aug 18.
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  Data: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
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