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Saracatinib, a Selective Src Kinase Inhibitor, Blocks Fibrotic Responses in Preclinical Models of Pulmonary Fibrosis.

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Title: Saracatinib, a Selective Src Kinase Inhibitor, Blocks Fibrotic Responses in Preclinical Models of Pulmonary Fibrosis.
Authors: Ahangari F; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut., Becker C; Institute for Next Generation Healthcare, Department of Genetics and Genomic Sciences, and.; Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York., Foster DG; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Department of Pediatrics, and Department of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado., Chioccioli M; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut., Nelson M; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Department of Pediatrics, and Department of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado., Beke K; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Department of Pediatrics, and Department of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado., Wang X; Institute for Next Generation Healthcare, Department of Genetics and Genomic Sciences, and.; Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York., Justet A; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.; Service de Pneumologie, UNICAEN, Normandie University, Caen, France., Adams T; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut., Readhead B; Institute for Next Generation Healthcare, Department of Genetics and Genomic Sciences, and.; ASU-Banner Neurodegenerative Disease Research Center, Arizona State University, Tempe, Arizona., Meador C; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Department of Pediatrics, and Department of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado., Correll K; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Department of Pediatrics, and Department of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado., Lili LN; Institute for Next Generation Healthcare, Department of Genetics and Genomic Sciences, and., Roybal HM; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Department of Pediatrics, and Department of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado., Rose KA; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut., Ding S; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut., Barnthaler T; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut.; Section of Pharmacology, Otto Loewi Research Center, Medical University of Graz, Graz, Austria., Briones N; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Department of Pediatrics, and Department of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado., DeIuliis G; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut., Schupp JC; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut., Li Q; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut., Omote N; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut., Aschner Y; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Department of Pediatrics, and Department of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado., Sharma L; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut., Kopf KW; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Department of Pediatrics, and Department of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado., Magnusson B; Discovery Biology, Discovery Sciences, Research & Development, AstraZeneca, Gothenburg, Sweden., Hicks R; BioPharmaceuticals Research & Development Cell Therapy, Research, and Early Development, Cardiovascular, Renal, and Metabolism (CVRM), AstraZeneca, Gothenburg, Sweden., Backmark A; Discovery Biology, Discovery Sciences, Research & Development, AstraZeneca, Gothenburg, Sweden., Dela Cruz CS; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut., Rosas I; Department of Medicine, Baylor College of Medicine, Houston, Texas; and., Cousens LP; Emerging Innovations, Discovery Sciences, Research & Development, AstraZeneca, Boston, Massachusetts., Dudley JT; Institute for Next Generation Healthcare, Department of Genetics and Genomic Sciences, and., Kaminski N; Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut., Downey GP; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Department of Pediatrics, and Department of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado.
Source: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2022 Dec 15; Vol. 206 (12), pp. 1463-1479.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Thoracic Society Country of Publication: United States NLM ID: 9421642 Publication Model: Print Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE
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