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Multifunctional nanoparticle potentiates the in situ vaccination effect of radiation therapy and enhances response to immune checkpoint blockade.

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Title: Multifunctional nanoparticle potentiates the in situ vaccination effect of radiation therapy and enhances response to immune checkpoint blockade.
Authors: Zhang Y; Department of Biomedical Engineering and Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA.; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA., Sriramaneni RN; Department of Human Oncology, University of Wisconsin-Madison, Madison, WI, USA., Clark PA; Department of Human Oncology, University of Wisconsin-Madison, Madison, WI, USA., Jagodinsky JC; Department of Human Oncology, University of Wisconsin-Madison, Madison, WI, USA., Ye M; Department of Biomedical Engineering and Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA.; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA., Jin W; Department of Human Oncology, University of Wisconsin-Madison, Madison, WI, USA., Wang Y; Department of Biomedical Engineering and Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA.; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA., Bates A; Department of Human Oncology, University of Wisconsin-Madison, Madison, WI, USA., Kerr CP; Department of Human Oncology, University of Wisconsin-Madison, Madison, WI, USA.; Department of Radiology, University of Wisconsin-Madison, Madison, WI, USA., Le T; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA., Allawi R; Department of Human Oncology, University of Wisconsin-Madison, Madison, WI, USA., Wang X; Department of Biomedical Engineering and Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA.; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA., Xie R; Department of Biomedical Engineering and Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA.; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA., Havighurst TC; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA., Chakravarty I; Department of Human Oncology, University of Wisconsin-Madison, Madison, WI, USA., Rakhmilevich AL; Department of Human Oncology, University of Wisconsin-Madison, Madison, WI, USA., O'Leary KA; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, USA., Schuler LA; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI, USA., Sondel PM; Department of Human Oncology, University of Wisconsin-Madison, Madison, WI, USA.; Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA., Kim K; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA., Gong S; Department of Biomedical Engineering and Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA. shaoqingong@wisc.edu.; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA. shaoqingong@wisc.edu., Morris ZS; Department of Human Oncology, University of Wisconsin-Madison, Madison, WI, USA. zmorris@humonc.wisc.edu.
Source: Nature communications [Nat Commun] 2022 Aug 23; Vol. 13 (1), pp. 4948. Date of Electronic Publication: 2022 Aug 23.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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