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Doxycycline inhibits the progression of metastases in early-stage osteosarcoma by downregulating the expression of MMPs, VEGF and ezrin at primary sites.

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Title: Doxycycline inhibits the progression of metastases in early-stage osteosarcoma by downregulating the expression of MMPs, VEGF and ezrin at primary sites.
Authors: Hadjimichael AC; Department of Orthopaedics, St Mary's Hospital, Imperial College Healthcare NHS Trust, Praed Street, W2 1NY, London, UK. Electronic address: ortho.argiris@gmail.com., Foukas AF; Third Department of Orthopaedic surgery, 'KAT' General Hospital of Athens, 2, Nikis Street, 14561, Kifissia, Greece. Electronic address: afoukas1@otenet.gr., Papadimitriou E; Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504, Patras, Greece. Electronic address: epapad@upatras.gr., Kaspiris A; Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504, Patras, Greece. Electronic address: angkaspiris@hotmail.com., Peristiani C; Medical School, National and Kapodistrian University of Athens,75, Mikras Asias Street, Goudi, 11527, Athens, Greece. Electronic address: chryso_perist@hotmail.gr., Chaniotakis I; Healthcare Directorate of the Hellenic Air Force General Staff, Athens, 3, P. Kanellopoulou Street, 11525, Athens, Greece. Electronic address: giannisxaniotakis@yahoo.gr., Kotsari M; Physiology Laboratory, Athens Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias Street, Physiology Lab, Bld 16, Goudi, 11527, Athens, Greece.. Electronic address: mkotsari@gmail.com., Pergaris A; First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias Street, Bld 10, Goudi, 11527 Athens, Greece. Electronic address: alexperg@yahoo.com., Theocharis S; First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias Street, Bld 10, Goudi, 11527 Athens, Greece. Electronic address: stamtheo@med.uoa.gr., Sarantis P; First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias Street, Bld 10, Goudi, 11527 Athens, Greece. Electronic address: psarantis@med.uoa.gr., Christopoulou M; Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504, Patras, Greece. Electronic address: magda.chris.77@gmail.com., Psyrri A; Section of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, National and Kapodistrian University of Athens, Attikon University Hospital,1 Rimini Street, Chaidari, 12462, Athens, Greece. Electronic address: psyrri237@yahoo.com., Mavrogenis AF; First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, Faculty of Medicine, Attikon University hospital, Athens,1 Rimini Street, Chaidari,12462, Athens, Greece.. Electronic address: afm@otenet.gr., Savvidou OD; First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, Faculty of Medicine, Attikon University hospital, Athens,1 Rimini Street, Chaidari,12462, Athens, Greece.. Electronic address: olgasavvidou@gmail.com., Papagelopoulos PJ; First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, Faculty of Medicine, Attikon University hospital, Athens,1 Rimini Street, Chaidari,12462, Athens, Greece.. Electronic address: pjporthopedic@gmail.com., Armakolas A; Physiology Laboratory, Athens Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias Street, Physiology Lab, Bld 16, Goudi, 11527, Athens, Greece.. Electronic address: aarmakol@med.uoa.gr.
Source: Cancer treatment and research communications [Cancer Treat Res Commun] 2022; Vol. 32, pp. 100617. Date of Electronic Publication: 2022 Aug 05.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101694651 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2468-2942 (Electronic) Linking ISSN: 24682942 NLM ISO Abbreviation: Cancer Treat Res Commun Subsets: MEDLINE
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  Data: Doxycycline inhibits the progression of metastases in early-stage osteosarcoma by downregulating the expression of MMPs, VEGF and ezrin at primary sites.
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  Data: <searchLink fieldCode="AU" term="%22Hadjimichael+AC%22">Hadjimichael AC</searchLink>; Department of Orthopaedics, St Mary's Hospital, Imperial College Healthcare NHS Trust, Praed Street, W2 1NY, London, UK. Electronic address: ortho.argiris@gmail.com.<br /><searchLink fieldCode="AU" term="%22Foukas+AF%22">Foukas AF</searchLink>; Third Department of Orthopaedic surgery, 'KAT' General Hospital of Athens, 2, Nikis Street, 14561, Kifissia, Greece. Electronic address: afoukas1@otenet.gr.<br /><searchLink fieldCode="AU" term="%22Papadimitriou+E%22">Papadimitriou E</searchLink>; Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504, Patras, Greece. Electronic address: epapad@upatras.gr.<br /><searchLink fieldCode="AU" term="%22Kaspiris+A%22">Kaspiris A</searchLink>; Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504, Patras, Greece. Electronic address: angkaspiris@hotmail.com.<br /><searchLink fieldCode="AU" term="%22Peristiani+C%22">Peristiani C</searchLink>; Medical School, National and Kapodistrian University of Athens,75, Mikras Asias Street, Goudi, 11527, Athens, Greece. Electronic address: chryso_perist@hotmail.gr.<br /><searchLink fieldCode="AU" term="%22Chaniotakis+I%22">Chaniotakis I</searchLink>; Healthcare Directorate of the Hellenic Air Force General Staff, Athens, 3, P. Kanellopoulou Street, 11525, Athens, Greece. Electronic address: giannisxaniotakis@yahoo.gr.<br /><searchLink fieldCode="AU" term="%22Kotsari+M%22">Kotsari M</searchLink>; Physiology Laboratory, Athens Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias Street, Physiology Lab, Bld 16, Goudi, 11527, Athens, Greece.. Electronic address: mkotsari@gmail.com.<br /><searchLink fieldCode="AU" term="%22Pergaris+A%22">Pergaris A</searchLink>; First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias Street, Bld 10, Goudi, 11527 Athens, Greece. Electronic address: alexperg@yahoo.com.<br /><searchLink fieldCode="AU" term="%22Theocharis+S%22">Theocharis S</searchLink>; First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias Street, Bld 10, Goudi, 11527 Athens, Greece. Electronic address: stamtheo@med.uoa.gr.<br /><searchLink fieldCode="AU" term="%22Sarantis+P%22">Sarantis P</searchLink>; First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias Street, Bld 10, Goudi, 11527 Athens, Greece. Electronic address: psarantis@med.uoa.gr.<br /><searchLink fieldCode="AU" term="%22Christopoulou+M%22">Christopoulou M</searchLink>; Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, 26504, Patras, Greece. Electronic address: magda.chris.77@gmail.com.<br /><searchLink fieldCode="AU" term="%22Psyrri+A%22">Psyrri A</searchLink>; Section of Medical Oncology, Department of Internal Medicine, Faculty of Medicine, National and Kapodistrian University of Athens, Attikon University Hospital,1 Rimini Street, Chaidari, 12462, Athens, Greece. Electronic address: psyrri237@yahoo.com.<br /><searchLink fieldCode="AU" term="%22Mavrogenis+AF%22">Mavrogenis AF</searchLink>; First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, Faculty of Medicine, Attikon University hospital, Athens,1 Rimini Street, Chaidari,12462, Athens, Greece.. Electronic address: afm@otenet.gr.<br /><searchLink fieldCode="AU" term="%22Savvidou+OD%22">Savvidou OD</searchLink>; First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, Faculty of Medicine, Attikon University hospital, Athens,1 Rimini Street, Chaidari,12462, Athens, Greece.. Electronic address: olgasavvidou@gmail.com.<br /><searchLink fieldCode="AU" term="%22Papagelopoulos+PJ%22">Papagelopoulos PJ</searchLink>; First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, Faculty of Medicine, Attikon University hospital, Athens,1 Rimini Street, Chaidari,12462, Athens, Greece.. Electronic address: pjporthopedic@gmail.com.<br /><searchLink fieldCode="AU" term="%22Armakolas+A%22">Armakolas A</searchLink>; Physiology Laboratory, Athens Medical School, National and Kapodistrian University of Athens, 75, Mikras Asias Street, Physiology Lab, Bld 16, Goudi, 11527, Athens, Greece.. Electronic address: aarmakol@med.uoa.gr.
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  Data: <searchLink fieldCode="JN" term="%22101694651%22">Cancer treatment and research communications</searchLink> [Cancer Treat Res Commun] 2022; Vol. 32, pp. 100617. <i>Date of Electronic Publication: </i>2022 Aug 05.
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