Perturbing DDR signaling enhances cytotoxic effects of local oncolytic virotherapy and modulates the immune environment in glioma.

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Title: Perturbing DDR signaling enhances cytotoxic effects of local oncolytic virotherapy and modulates the immune environment in glioma.
Authors: Koch MS; Harvey Cushing Neurooncology Research Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA., Zdioruk M; Harvey Cushing Neurooncology Research Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA., Nowicki MO; Harvey Cushing Neurooncology Research Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA., Griffith AM; Department of Surgery, Brigham & Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA., Aguilar-Cordova E; Candel Therapeutics, 117 Kendrick St, Suite 450, Needham, MA 02494, USA., Aguilar LK; Candel Therapeutics, 117 Kendrick St, Suite 450, Needham, MA 02494, USA., Guzik BW; Candel Therapeutics, 117 Kendrick St, Suite 450, Needham, MA 02494, USA., Barone F; Candel Therapeutics, 117 Kendrick St, Suite 450, Needham, MA 02494, USA., Tak PP; Candel Therapeutics, 117 Kendrick St, Suite 450, Needham, MA 02494, USA., Schregel K; Department of Neuroradiology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany., Hoetker MS; Department of Molecular Biology, Massachusetts General Hospital, 185 Cambridge St, Boston, MA 02114, USA., Lederer JA; Department of Surgery, Brigham & Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA., Chiocca EA; Harvey Cushing Neurooncology Research Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA., Tabatabai G; Department of Neurology and Interdisciplinary Neuro-Oncology, University Hospital Tübingen, Hertie Institut for Clinical Brain Research, Eberhard Karls University Tübingen, Hoppe-Seyler-Straße 6, 72076 Tübingen, Germany., Lawler SE; Harvey Cushing Neurooncology Research Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA.
Source: Molecular therapy oncolytics [Mol Ther Oncolytics] 2022 Jul 31; Vol. 26, pp. 275-288. Date of Electronic Publication: 2022 Jul 31 (Print Publication: 2022).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101666776 Publication Model: eCollection Cited Medium: Print ISSN: 2372-7705 (Print) Linking ISSN: 23727705 NLM ISO Abbreviation: Mol Ther Oncolytics Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2372-7705
DOI:10.1016/j.omto.2022.07.009