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Increasing test specificity without impairing sensitivity: lessons learned from SARS-CoV-2 serology.

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Title: Increasing test specificity without impairing sensitivity: lessons learned from SARS-CoV-2 serology.
Authors: Perkmann T; Department of Laboratory Medicine, Medical University of Vienna, Wien, Austria., Koller T; Department of Laboratory Medicine, Medical University of Vienna, Wien, Austria., Perkmann-Nagele N; Department of Laboratory Medicine, Medical University of Vienna, Wien, Austria., Ozsvar-Kozma M; Department of Laboratory Medicine, Medical University of Vienna, Wien, Austria., Eyre D; Big Data Institute, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Matthews P; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Bown A; Public Health England Porton Down, Salisbury, UK., Stoesser N; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Breyer MK; Department of Respiratory and Critical Care Medicine, Clinic Penzing, Vienna, Austria.; Ludwig Boltzmann Institute for Lung Health, Vienna, Austria., Breyer-Kohansal R; Department of Respiratory and Critical Care Medicine, Clinic Penzing, Vienna, Austria.; Ludwig Boltzmann Institute for Lung Health, Vienna, Austria., Burghuber OC; Ludwig Boltzmann Institute for Lung Health, Vienna, Austria.; Sigmund Freud Private University Vienna, Vienna, Austria., Hartl S; Department of Respiratory and Critical Care Medicine, Clinic Penzing, Vienna, Austria.; Ludwig Boltzmann Institute for Lung Health, Vienna, Austria.; Sigmund Freud Private University Vienna, Vienna, Austria., Aletaha D; Division of Rheumatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria., Sieghart D; Division of Rheumatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria., Quehenberger P; Department of Laboratory Medicine, Medical University of Vienna, Wien, Austria., Marculescu R; Department of Laboratory Medicine, Medical University of Vienna, Wien, Austria., Mucher P; Department of Laboratory Medicine, Medical University of Vienna, Wien, Austria., Radakovics A; Department of Laboratory Medicine, Medical University of Vienna, Wien, Austria., Klausberger M; Institute of Molecular Biotechnology, Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Vienna, Austria., Duerkop M; Institute of Bioprocess Science and Engineering, Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Vienna, Austria., Holzer B; Institute for Veterinary Disease Control, Austrian Agency for Health and Food Safety (AGES), Moedling, Austria., Hartmann B; Institute for Veterinary Disease Control, Austrian Agency for Health and Food Safety (AGES), Moedling, Austria., Strassl R; Department of Laboratory Medicine, Medical University of Vienna, Wien, Austria., Leitner G; Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria., Grebien F; Institute for Medical Biochemistry, University of Veterinary Medicine Vienna, Vienna, Austria., Gerner W; Institute of Immunology, University of Veterinary Medicine Vienna, Vienna, Austria.; Christian Doppler Laboratory for an Optimized Prediction of Vaccination Success in Pigs, University of Veterinary Medicine Vienna, Vienna, Austria.; The Pirbright Institute, Pirbright, UK (current)., Grabherr R; Institute of Molecular Biotechnology, Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Vienna, Austria., Wagner OF; Department of Laboratory Medicine, Medical University of Vienna, Wien, Austria., Binder CJ; Department of Laboratory Medicine, Medical University of Vienna, Wien, Austria., Haslacher H; Department of Laboratory Medicine, Medical University of Vienna, Wien, Austria helmuth.haslacher@meduniwien.ac.at.
Source: Journal of clinical pathology [J Clin Pathol] 2023 Nov; Vol. 76 (11), pp. 770-777. Date of Electronic Publication: 2022 Aug 30.
Publication Type: Journal Article
Journal Info: Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 0376601 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1472-4146 (Electronic) Linking ISSN: 00219746 NLM ISO Abbreviation: J Clin Pathol Subsets: MEDLINE
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  Data: Increasing test specificity without impairing sensitivity: lessons learned from SARS-CoV-2 serology.
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  Data: <searchLink fieldCode="AU" term="%22Perkmann+T%22">Perkmann T</searchLink>; Department of Laboratory Medicine, Medical University of Vienna, Wien, Austria.<br /><searchLink fieldCode="AU" term="%22Koller+T%22">Koller T</searchLink>; Department of Laboratory Medicine, Medical University of Vienna, Wien, Austria.<br /><searchLink fieldCode="AU" term="%22Perkmann-Nagele+N%22">Perkmann-Nagele N</searchLink>; Department of Laboratory Medicine, Medical University of Vienna, Wien, Austria.<br /><searchLink fieldCode="AU" term="%22Ozsvar-Kozma+M%22">Ozsvar-Kozma M</searchLink>; Department of Laboratory Medicine, Medical University of Vienna, Wien, Austria.<br /><searchLink fieldCode="AU" term="%22Eyre+D%22">Eyre D</searchLink>; Big Data Institute, Nuffield Department of Population Health, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Matthews+P%22">Matthews P</searchLink>; Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Bown+A%22">Bown A</searchLink>; Public Health England Porton Down, Salisbury, UK.<br /><searchLink fieldCode="AU" term="%22Stoesser+N%22">Stoesser N</searchLink>; Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Breyer+MK%22">Breyer MK</searchLink>; Department of Respiratory and Critical Care Medicine, Clinic Penzing, Vienna, Austria.; Ludwig Boltzmann Institute for Lung Health, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Breyer-Kohansal+R%22">Breyer-Kohansal R</searchLink>; Department of Respiratory and Critical Care Medicine, Clinic Penzing, Vienna, Austria.; Ludwig Boltzmann Institute for Lung Health, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Burghuber+OC%22">Burghuber OC</searchLink>; Ludwig Boltzmann Institute for Lung Health, Vienna, Austria.; Sigmund Freud Private University Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Hartl+S%22">Hartl S</searchLink>; Department of Respiratory and Critical Care Medicine, Clinic Penzing, Vienna, Austria.; Ludwig Boltzmann Institute for Lung Health, Vienna, Austria.; Sigmund Freud Private University Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Aletaha+D%22">Aletaha D</searchLink>; Division of Rheumatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Sieghart+D%22">Sieghart D</searchLink>; Division of Rheumatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Quehenberger+P%22">Quehenberger P</searchLink>; Department of Laboratory Medicine, Medical University of Vienna, Wien, Austria.<br /><searchLink fieldCode="AU" term="%22Marculescu+R%22">Marculescu R</searchLink>; Department of Laboratory Medicine, Medical University of Vienna, Wien, Austria.<br /><searchLink fieldCode="AU" term="%22Mucher+P%22">Mucher P</searchLink>; Department of Laboratory Medicine, Medical University of Vienna, Wien, Austria.<br /><searchLink fieldCode="AU" term="%22Radakovics+A%22">Radakovics A</searchLink>; Department of Laboratory Medicine, Medical University of Vienna, Wien, Austria.<br /><searchLink fieldCode="AU" term="%22Klausberger+M%22">Klausberger M</searchLink>; Institute of Molecular Biotechnology, Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Duerkop+M%22">Duerkop M</searchLink>; Institute of Bioprocess Science and Engineering, Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Holzer+B%22">Holzer B</searchLink>; Institute for Veterinary Disease Control, Austrian Agency for Health and Food Safety (AGES), Moedling, Austria.<br /><searchLink fieldCode="AU" term="%22Hartmann+B%22">Hartmann B</searchLink>; Institute for Veterinary Disease Control, Austrian Agency for Health and Food Safety (AGES), Moedling, Austria.<br /><searchLink fieldCode="AU" term="%22Strassl+R%22">Strassl R</searchLink>; Department of Laboratory Medicine, Medical University of Vienna, Wien, Austria.<br /><searchLink fieldCode="AU" term="%22Leitner+G%22">Leitner G</searchLink>; Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Grebien+F%22">Grebien F</searchLink>; Institute for Medical Biochemistry, University of Veterinary Medicine Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Gerner+W%22">Gerner W</searchLink>; Institute of Immunology, University of Veterinary Medicine Vienna, Vienna, Austria.; Christian Doppler Laboratory for an Optimized Prediction of Vaccination Success in Pigs, University of Veterinary Medicine Vienna, Vienna, Austria.; The Pirbright Institute, Pirbright, UK (current).<br /><searchLink fieldCode="AU" term="%22Grabherr+R%22">Grabherr R</searchLink>; Institute of Molecular Biotechnology, Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Wagner+OF%22">Wagner OF</searchLink>; Department of Laboratory Medicine, Medical University of Vienna, Wien, Austria.<br /><searchLink fieldCode="AU" term="%22Binder+CJ%22">Binder CJ</searchLink>; Department of Laboratory Medicine, Medical University of Vienna, Wien, Austria.<br /><searchLink fieldCode="AU" term="%22Haslacher+H%22">Haslacher H</searchLink>; Department of Laboratory Medicine, Medical University of Vienna, Wien, Austria helmuth.haslacher@meduniwien.ac.at.
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  Data: <searchLink fieldCode="JN" term="%220376601%22">Journal of clinical pathology</searchLink> [J Clin Pathol] 2023 Nov; Vol. 76 (11), pp. 770-777. <i>Date of Electronic Publication: </i>2022 Aug 30.
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