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Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia.

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Title: Small-Molecule Inhibition of the Acyl-Lysine Reader ENL as a Strategy against Acute Myeloid Leukemia.
Authors: Liu Y; Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Li Q; Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Alikarami F; Division of Pediatric Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Barrett DR; Division of Pediatric Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Mahdavi L; Division of Pediatric Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Li H; Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Department of the School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, Pennsylvania., Tang S; Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Khan TA; Tri-Institutional Therapeutics Discovery Institute, New York, New York., Michino M; Tri-Institutional Therapeutics Discovery Institute, New York, New York., Hill C; Wistar Institute, Gene Expression and Regulation Program, Philadelphia, Pennsylvania.; Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Pennsylvania., Song L; Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Yang L; Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, California., Li Y; MOE Key Laboratory of Protein Sciences, Beijing Frontier Research Center for Biological Structure, School of Medicine, Tsinghua University, and Tsinghua-Peking Center for Life Sciences, Beijing, China., Pokharel SP; Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, California., Stamford AW; Tri-Institutional Therapeutics Discovery Institute, New York, New York., Liverton N; Tri-Institutional Therapeutics Discovery Institute, New York, New York., Renzetti LM; Bridge Medicines, New York, New York., Taylor S; Pharmaron Drug Discovery, Pharmaron UK, West Hill Innovation Park, Hertford Road, Hoddesdon, Hertfordshire, United Kingdom., Watt GF; Pharmaron Drug Discovery, Pharmaron UK, West Hill Innovation Park, Hertford Road, Hoddesdon, Hertfordshire, United Kingdom., Ladduwahetty T; Pharmaron Drug Discovery, Pharmaron UK, West Hill Innovation Park, Hertford Road, Hoddesdon, Hertfordshire, United Kingdom., Kargman S; Tri-Institutional Therapeutics Discovery Institute, New York, New York.; Bridge Medicines, New York, New York., Meinke PT; Tri-Institutional Therapeutics Discovery Institute, New York, New York.; Department of Pharmacology, Weill Cornell Medical College, New York, New York., Foley MA; Tri-Institutional Therapeutics Discovery Institute, New York, New York., Shi J; Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Li H; MOE Key Laboratory of Protein Sciences, Beijing Frontier Research Center for Biological Structure, School of Medicine, Tsinghua University, and Tsinghua-Peking Center for Life Sciences, Beijing, China., Carroll M; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Chen CW; Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, California., Gardini A; Wistar Institute, Gene Expression and Regulation Program, Philadelphia, Pennsylvania., Maillard I; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Huggins DJ; Tri-Institutional Therapeutics Discovery Institute, New York, New York.; Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York., Bernt KM; Division of Pediatric Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Wan L; Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Source: Cancer discovery [Cancer Discov] 2022 Nov 02; Vol. 12 (11), pp. 2684-2709.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
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Division of Pediatric Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Department of the School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Tang+S%22">Tang S</searchLink>; Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Khan+TA%22">Khan TA</searchLink>; Tri-Institutional Therapeutics Discovery Institute, New York, New York.<br /><searchLink fieldCode="AU" term="%22Michino+M%22">Michino M</searchLink>; 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MOE Key Laboratory of Protein Sciences, Beijing Frontier Research Center for Biological Structure, School of Medicine, Tsinghua University, and Tsinghua-Peking Center for Life Sciences, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Carroll+M%22">Carroll M</searchLink>; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Chen+CW%22">Chen CW</searchLink>; Department of Systems Biology, Beckman Research Institute, City of Hope, Duarte, California.<br /><searchLink fieldCode="AU" term="%22Gardini+A%22">Gardini A</searchLink>; Wistar Institute, Gene Expression and Regulation Program, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Maillard+I%22">Maillard I</searchLink>; Division of Hematology/Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Huggins+DJ%22">Huggins DJ</searchLink>; Tri-Institutional Therapeutics Discovery Institute, New York, New York.; Department of Physiology and Biophysics, Weill Cornell Medical College, New York, New York.<br /><searchLink fieldCode="AU" term="%22Bernt+KM%22">Bernt KM</searchLink>; Division of Pediatric Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Wan+L%22">Wan L</searchLink>; Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania.; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
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