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Complex in vitro 3D models of digestive system tumors to advance precision medicine and drug testing: Progress, challenges, and trends.

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Title: Complex in vitro 3D models of digestive system tumors to advance precision medicine and drug testing: Progress, challenges, and trends.
Authors: Song SL; Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, PR China; Digestive Diseases Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518107, PR China; Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, PR China., Li B; Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, PR China; Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518107, PR China., Carvalho MR; 3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal., Wang HJ; Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, PR China; Digestive Diseases Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518107, PR China; Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, PR China., Mao DL; Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, PR China; Digestive Diseases Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518107, PR China; Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, PR China., Wei JT; Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, PR China; Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518107, PR China., Chen W; Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, PR China., Weng ZH; Cancer Center Faculty of Health Sciences, University of Macau, Macau 999078, PR China; Center for Precision Medicine Research and Training Faculty of Health Sciences, University of Macau, Macau 999078, PR China., Chen YC; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin NT, Hong Kong, PR China., Deng CX; Cancer Center Faculty of Health Sciences, University of Macau, Macau 999078, PR China; Center for Precision Medicine Research and Training Faculty of Health Sciences, University of Macau, Macau 999078, PR China., Reis RL; 3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal., Oliveira JM; 3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal. Electronic address: miguel.oliveira@i3bs.uminho.pt., He YL; Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, PR China; Digestive Diseases Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518107, PR China; Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, PR China. Electronic address: heyulong@mail.sysu.edu.cn., Yan LP; Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, PR China; Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518107, PR China. Electronic address: yanlp3@mail.sysu.edu.cn., Zhang CH; Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, PR China; Digestive Diseases Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518107, PR China. Electronic address: zhchangh@mail.sysu.edu.cn.
Source: Pharmacology & therapeutics [Pharmacol Ther] 2022 Nov; Vol. 239, pp. 108276. Date of Electronic Publication: 2022 Aug 31.
Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 7905840 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-016X (Electronic) Linking ISSN: 01637258 NLM ISO Abbreviation: Pharmacol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Complex in vitro 3D models of digestive system tumors to advance precision medicine and drug testing: Progress, challenges, and trends.
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  Data: <searchLink fieldCode="AU" term="%22Song+SL%22">Song SL</searchLink>; Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, PR China; Digestive Diseases Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518107, PR China; Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, PR China.<br /><searchLink fieldCode="AU" term="%22Li+B%22">Li B</searchLink>; Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, PR China; Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518107, PR China.<br /><searchLink fieldCode="AU" term="%22Carvalho+MR%22">Carvalho MR</searchLink>; 3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.<br /><searchLink fieldCode="AU" term="%22Wang+HJ%22">Wang HJ</searchLink>; Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, PR China; Digestive Diseases Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518107, PR China; Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, PR China.<br /><searchLink fieldCode="AU" term="%22Mao+DL%22">Mao DL</searchLink>; Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, PR China; Digestive Diseases Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518107, PR China; Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, PR China.<br /><searchLink fieldCode="AU" term="%22Wei+JT%22">Wei JT</searchLink>; Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, PR China; Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518107, PR China.<br /><searchLink fieldCode="AU" term="%22Chen+W%22">Chen W</searchLink>; Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, PR China.<br /><searchLink fieldCode="AU" term="%22Weng+ZH%22">Weng ZH</searchLink>; Cancer Center Faculty of Health Sciences, University of Macau, Macau 999078, PR China; Center for Precision Medicine Research and Training Faculty of Health Sciences, University of Macau, Macau 999078, PR China.<br /><searchLink fieldCode="AU" term="%22Chen+YC%22">Chen YC</searchLink>; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin NT, Hong Kong, PR China.<br /><searchLink fieldCode="AU" term="%22Deng+CX%22">Deng CX</searchLink>; Cancer Center Faculty of Health Sciences, University of Macau, Macau 999078, PR China; Center for Precision Medicine Research and Training Faculty of Health Sciences, University of Macau, Macau 999078, PR China.<br /><searchLink fieldCode="AU" term="%22Reis+RL%22">Reis RL</searchLink>; 3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.<br /><searchLink fieldCode="AU" term="%22Oliveira+JM%22">Oliveira JM</searchLink>; 3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal. Electronic address: miguel.oliveira@i3bs.uminho.pt.<br /><searchLink fieldCode="AU" term="%22He+YL%22">He YL</searchLink>; Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, PR China; Digestive Diseases Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518107, PR China; Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, PR China. Electronic address: heyulong@mail.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Yan+LP%22">Yan LP</searchLink>; Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, PR China; Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518107, PR China. Electronic address: yanlp3@mail.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+CH%22">Zhang CH</searchLink>; Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, PR China; Digestive Diseases Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518107, PR China. Electronic address: zhchangh@mail.sysu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%227905840%22">Pharmacology & therapeutics</searchLink> [Pharmacol Ther] 2022 Nov; Vol. 239, pp. 108276. <i>Date of Electronic Publication: </i>2022 Aug 31.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Pergamon+Press%22">Pergamon Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>7905840 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-016X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201637258%22">01637258 </searchLink><i>NLM ISO Abbreviation: </i>Pharmacol Ther <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.pharmthera.2022.108276
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