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Low dose interleukin-2 selectively expands circulating regulatory T cells but fails to promote liver allograft tolerance in humans.

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Title: Low dose interleukin-2 selectively expands circulating regulatory T cells but fails to promote liver allograft tolerance in humans.
Authors: Lim TY; Institute of Liver Studies, King's College Hospital, Medical Research Council (MRC) Centre for Transplantation, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK., Perpiñán E; Institute of Liver Studies, King's College Hospital, Medical Research Council (MRC) Centre for Transplantation, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK., Londoño MC; Institute of Liver Studies, King's College Hospital, Medical Research Council (MRC) Centre for Transplantation, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK; Liver Unit, Hospital Clínic Barcelona, IDIBAPS, CIBERehd, Barcelona, Spain., Miquel R; Institute of Liver Studies, King's College Hospital, Medical Research Council (MRC) Centre for Transplantation, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK; Liver Histopathology Laboratory, King's College Hospital, London, UK., Ruiz P; Institute of Liver Studies, King's College Hospital, Medical Research Council (MRC) Centre for Transplantation, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK., Kurt AS; Institute of Liver Studies, King's College Hospital, Medical Research Council (MRC) Centre for Transplantation, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK., Kodela E; Institute of Liver Studies, King's College Hospital, Medical Research Council (MRC) Centre for Transplantation, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK., Cross AR; Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK., Berlin C; Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK., Hester J; Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK., Issa F; Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK., Douiri A; School of Population Health and Environmental Sciences, King's College London, London, UK., Volmer FH; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany., Taubert R; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany., Williams E; Department of Immunobiology, School of Immunology & Microbial Sciences (SIMS), King's College London, London, UK., Demetris AJ; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA., Lesniak A; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA., Bensimon G; Département de Pharmacologie Clinique, Hôpital de la Pitié-Salpêtrière et UPMC Pharmacologie, Paris-Sorbonne Université, Paris, France; Laboratoire de Biostatistique, Epidémiologie Clinique, Santé Publique Innovation et Méthodologie (BESPIM), CHU-Nîmes, Nîmes, France., Lozano JJ; Bioinformatic Platform, Biomedical Research Center in Hepatic and Digestive Diseases (CIBEREHD), Carlos III Health Institute, Barcelona, Spain., Martinez-Llordella M; Institute of Liver Studies, King's College Hospital, Medical Research Council (MRC) Centre for Transplantation, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK., Tree T; Department of Immunobiology, School of Immunology & Microbial Sciences (SIMS), King's College London, London, UK., Sánchez-Fueyo A; Institute of Liver Studies, King's College Hospital, Medical Research Council (MRC) Centre for Transplantation, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK. Electronic address: sanchez_fueyo@kcl.ac.uk.
Source: Journal of hepatology [J Hepatol] 2023 Jan; Vol. 78 (1), pp. 153-164. Date of Electronic Publication: 2022 Sep 07.
Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Low dose interleukin-2 selectively expands circulating regulatory T cells but fails to promote liver allograft tolerance in humans.
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  Data: <searchLink fieldCode="AU" term="%22Lim+TY%22">Lim TY</searchLink>; Institute of Liver Studies, King's College Hospital, Medical Research Council (MRC) Centre for Transplantation, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Perpiñán+E%22">Perpiñán E</searchLink>; Institute of Liver Studies, King's College Hospital, Medical Research Council (MRC) Centre for Transplantation, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Londoño+MC%22">Londoño MC</searchLink>; Institute of Liver Studies, King's College Hospital, Medical Research Council (MRC) Centre for Transplantation, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK; Liver Unit, Hospital Clínic Barcelona, IDIBAPS, CIBERehd, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Miquel+R%22">Miquel R</searchLink>; Institute of Liver Studies, King's College Hospital, Medical Research Council (MRC) Centre for Transplantation, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK; Liver Histopathology Laboratory, King's College Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Ruiz+P%22">Ruiz P</searchLink>; Institute of Liver Studies, King's College Hospital, Medical Research Council (MRC) Centre for Transplantation, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Kurt+AS%22">Kurt AS</searchLink>; Institute of Liver Studies, King's College Hospital, Medical Research Council (MRC) Centre for Transplantation, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Kodela+E%22">Kodela E</searchLink>; Institute of Liver Studies, King's College Hospital, Medical Research Council (MRC) Centre for Transplantation, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Cross+AR%22">Cross AR</searchLink>; Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Berlin+C%22">Berlin C</searchLink>; Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Hester+J%22">Hester J</searchLink>; Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Issa+F%22">Issa F</searchLink>; Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Douiri+A%22">Douiri A</searchLink>; School of Population Health and Environmental Sciences, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Volmer+FH%22">Volmer FH</searchLink>; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Taubert+R%22">Taubert R</searchLink>; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Williams+E%22">Williams E</searchLink>; Department of Immunobiology, School of Immunology & Microbial Sciences (SIMS), King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Demetris+AJ%22">Demetris AJ</searchLink>; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lesniak+A%22">Lesniak A</searchLink>; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Bensimon+G%22">Bensimon G</searchLink>; Département de Pharmacologie Clinique, Hôpital de la Pitié-Salpêtrière et UPMC Pharmacologie, Paris-Sorbonne Université, Paris, France; Laboratoire de Biostatistique, Epidémiologie Clinique, Santé Publique Innovation et Méthodologie (BESPIM), CHU-Nîmes, Nîmes, France.<br /><searchLink fieldCode="AU" term="%22Lozano+JJ%22">Lozano JJ</searchLink>; Bioinformatic Platform, Biomedical Research Center in Hepatic and Digestive Diseases (CIBEREHD), Carlos III Health Institute, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Martinez-Llordella+M%22">Martinez-Llordella M</searchLink>; Institute of Liver Studies, King's College Hospital, Medical Research Council (MRC) Centre for Transplantation, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Tree+T%22">Tree T</searchLink>; Department of Immunobiology, School of Immunology & Microbial Sciences (SIMS), King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Sánchez-Fueyo+A%22">Sánchez-Fueyo A</searchLink>; Institute of Liver Studies, King's College Hospital, Medical Research Council (MRC) Centre for Transplantation, School of Immunology & Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK. Electronic address: sanchez_fueyo@kcl.ac.uk.
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  Data: <searchLink fieldCode="JN" term="%228503886%22">Journal of hepatology</searchLink> [J Hepatol] 2023 Jan; Vol. 78 (1), pp. 153-164. <i>Date of Electronic Publication: </i>2022 Sep 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>8503886 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1600-0641 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201688278%22">01688278 </searchLink><i>NLM ISO Abbreviation: </i>J Hepatol <i>Subsets: </i>MEDLINE
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