Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression Among Adults in the US Veterans Affairs Health Care System.

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Title: Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression Among Adults in the US Veterans Affairs Health Care System.
Authors: Bigdeli TB; VA New York Harbor Healthcare System, Brooklyn.; Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, New York.; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, New York., Voloudakis G; James J. Peters Veterans Affairs Medical Center, Bronx, New York.; Departments of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.; Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York., Barr PB; VA New York Harbor Healthcare System, Brooklyn.; Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, New York.; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, New York., Gorman BR; Massachusetts Area Veterans Epidemiology, Research, and Information Center (MAVERIC), Jamaica Plain., Genovese G; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Peterson RE; VA New York Harbor Healthcare System, Brooklyn.; Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, New York.; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, New York.; Department of Psychiatry, Virginia Commonwealth University, Richmond., Burstein DE; James J. Peters Veterans Affairs Medical Center, Bronx, New York.; Departments of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.; Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York., Velicu VI; James J. Peters Veterans Affairs Medical Center, Bronx, New York.; Departments of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.; Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York., Li Y; Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, Connecticut.; Yale University School of Medicine, New Haven, Connecticut., Gupta R; Department of Psychiatry, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts., Mattheisen M; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.; Department of Community Health, Dalhousie University, Halifax, Nova Scotia, Canada.; Department of Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada., Tomasi S; James J. Peters Veterans Affairs Medical Center, Bronx, New York.; Departments of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.; Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York., Rajeevan N; Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, Connecticut.; Yale University School of Medicine, New Haven, Connecticut., Sayward F; Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, Connecticut.; Yale University School of Medicine, New Haven, Connecticut., Radhakrishnan K; National Mental Health and Substance Use Policy Laboratory, Substance Abuse and Mental Health Services Administration, Rockville, Maryland., Natarajan S; VA New York Harbor Healthcare System, Brooklyn., Malhotra AK; Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, New York.; Division of Psychiatry Research, The Zucker Hillside Hospital, Northwell Health, Glen Oaks, New York.; Department of Psychiatry, Hofstra Northwell School of Medicine, Hempstead, New York., Shi Y; Massachusetts Area Veterans Epidemiology, Research, and Information Center (MAVERIC), Jamaica Plain., Zhao H; Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, Connecticut.; Yale University School of Medicine, New Haven, Connecticut., Kosten TR; Michael E. DeBakey VA Medical Center, Houston, Texas.; Department of Psychiatry, Neuroscience, Pharmacology, and Immunology and Rheumatology, Baylor College of Medicine, Houston, Texas., Concato J; Yale University School of Medicine, New Haven, Connecticut.; Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland., O'Leary TJ; Office of Research and Development, Veterans Health Administration, Washington, DC., Przygodzki R; Office of Research and Development, Veterans Health Administration, Washington, DC., Gleason T; Office of Research and Development, Veterans Health Administration, Washington, DC., Pyarajan S; Massachusetts Area Veterans Epidemiology, Research, and Information Center (MAVERIC), Jamaica Plain., Brophy M; Massachusetts Area Veterans Epidemiology, Research, and Information Center (MAVERIC), Jamaica Plain.; Boston University School of Medicine, Boston, Massachusetts., Huang GD; Office of Research and Development, Veterans Health Administration, Washington, DC., Muralidhar S; Office of Research and Development, Veterans Health Administration, Washington, DC., Gaziano JM; Massachusetts Area Veterans Epidemiology, Research, and Information Center (MAVERIC), Jamaica Plain.; Harvard Medical School, Boston, Massachusetts., Aslan M; Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, Connecticut.; Yale University School of Medicine, New Haven, Connecticut., Fanous AH; Department of Psychiatry, University of Arizona College of Medicine-Phoenix, Phoenix.; Carl T. Hayden Veterans Affairs Medical Center, Phoenix, Arizona., Harvey PD; Bruce W. Carter Miami Veterans Affairs (VA) Medical Center, Miami, Florida.; University of Miami Miller School of Medicine, Miami, Florida., Roussos P; James J. Peters Veterans Affairs Medical Center, Bronx, New York.; Departments of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.; Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.
Corporate Authors: Cooperative Studies Program (CSP) #572 and Million Veteran Program (MVP)
Source: JAMA psychiatry [JAMA Psychiatry] 2022 Sep 14. Date of Electronic Publication: 2022 Sep 14.
Publication Type: Journal Article
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2168-6238 (Electronic) Linking ISSN: 2168622X NLM ISO Abbreviation: JAMA Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2168-6238
DOI:10.1001/jamapsychiatry.2022.2742