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Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression Among Adults in the US Veterans Affairs Health Care System.

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Title: Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression Among Adults in the US Veterans Affairs Health Care System.
Authors: Bigdeli TB; VA New York Harbor Healthcare System, Brooklyn.; Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, New York.; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, New York., Voloudakis G; James J. Peters Veterans Affairs Medical Center, Bronx, New York.; Departments of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.; Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York., Barr PB; VA New York Harbor Healthcare System, Brooklyn.; Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, New York.; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, New York., Gorman BR; Massachusetts Area Veterans Epidemiology, Research, and Information Center (MAVERIC), Jamaica Plain., Genovese G; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Harvard Medical School, Boston, Massachusetts., Peterson RE; VA New York Harbor Healthcare System, Brooklyn.; Institute for Genomics in Health, SUNY Downstate Health Sciences University, Brooklyn, New York.; Department of Psychiatry and Behavioral Sciences, SUNY Downstate Health Sciences University, Brooklyn, New York.; Department of Psychiatry, Virginia Commonwealth University, Richmond., Burstein DE; James J. Peters Veterans Affairs Medical Center, Bronx, New York.; Departments of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.; Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York., Velicu VI; James J. Peters Veterans Affairs Medical Center, Bronx, New York.; Departments of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.; Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York., Li Y; Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, Connecticut.; Yale University School of Medicine, New Haven, Connecticut., Gupta R; Department of Psychiatry, Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts., Mattheisen M; Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.; Department of Community Health, Dalhousie University, Halifax, Nova Scotia, Canada.; Department of Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada., Tomasi S; James J. Peters Veterans Affairs Medical Center, Bronx, New York.; Departments of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.; Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York., Rajeevan N; Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, Connecticut.; Yale University School of Medicine, New Haven, Connecticut., Sayward F; Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, Connecticut.; Yale University School of Medicine, New Haven, Connecticut., Radhakrishnan K; National Mental Health and Substance Use Policy Laboratory, Substance Abuse and Mental Health Services Administration, Rockville, Maryland., Natarajan S; VA New York Harbor Healthcare System, Brooklyn., Malhotra AK; Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, New York.; Division of Psychiatry Research, The Zucker Hillside Hospital, Northwell Health, Glen Oaks, New York.; Department of Psychiatry, Hofstra Northwell School of Medicine, Hempstead, New York., Shi Y; Massachusetts Area Veterans Epidemiology, Research, and Information Center (MAVERIC), Jamaica Plain., Zhao H; Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, Connecticut.; Yale University School of Medicine, New Haven, Connecticut., Kosten TR; Michael E. DeBakey VA Medical Center, Houston, Texas.; Department of Psychiatry, Neuroscience, Pharmacology, and Immunology and Rheumatology, Baylor College of Medicine, Houston, Texas., Concato J; Yale University School of Medicine, New Haven, Connecticut.; Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland., O'Leary TJ; Office of Research and Development, Veterans Health Administration, Washington, DC., Przygodzki R; Office of Research and Development, Veterans Health Administration, Washington, DC., Gleason T; Office of Research and Development, Veterans Health Administration, Washington, DC., Pyarajan S; Massachusetts Area Veterans Epidemiology, Research, and Information Center (MAVERIC), Jamaica Plain., Brophy M; Massachusetts Area Veterans Epidemiology, Research, and Information Center (MAVERIC), Jamaica Plain.; Boston University School of Medicine, Boston, Massachusetts., Huang GD; Office of Research and Development, Veterans Health Administration, Washington, DC., Muralidhar S; Office of Research and Development, Veterans Health Administration, Washington, DC., Gaziano JM; Massachusetts Area Veterans Epidemiology, Research, and Information Center (MAVERIC), Jamaica Plain.; Harvard Medical School, Boston, Massachusetts., Aslan M; Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, Connecticut.; Yale University School of Medicine, New Haven, Connecticut., Fanous AH; Department of Psychiatry, University of Arizona College of Medicine-Phoenix, Phoenix.; Carl T. Hayden Veterans Affairs Medical Center, Phoenix, Arizona., Harvey PD; Bruce W. Carter Miami Veterans Affairs (VA) Medical Center, Miami, Florida.; University of Miami Miller School of Medicine, Miami, Florida., Roussos P; James J. Peters Veterans Affairs Medical Center, Bronx, New York.; Departments of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.; Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.
Corporate Authors: Cooperative Studies Program (CSP) #572 and Million Veteran Program (MVP)
Source: JAMA psychiatry [JAMA Psychiatry] 2022 Sep 14. Date of Electronic Publication: 2022 Sep 14.
Publication Type: Journal Article
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2168-6238 (Electronic) Linking ISSN: 2168622X NLM ISO Abbreviation: JAMA Psychiatry Subsets: MEDLINE
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  Data: Penetrance and Pleiotropy of Polygenic Risk Scores for Schizophrenia, Bipolar Disorder, and Depression Among Adults in the US Veterans Affairs Health Care System.
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Peters Veterans Affairs Medical Center, Bronx, New York.; Departments of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.; Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.<br /><searchLink fieldCode="AU" term="%22Rajeevan+N%22">Rajeevan N</searchLink>; Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, Connecticut.; Yale University School of Medicine, New Haven, Connecticut.<br /><searchLink fieldCode="AU" term="%22Sayward+F%22">Sayward F</searchLink>; Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, Connecticut.; Yale University School of Medicine, New Haven, Connecticut.<br /><searchLink fieldCode="AU" term="%22Radhakrishnan+K%22">Radhakrishnan K</searchLink>; National Mental Health and Substance Use Policy Laboratory, Substance Abuse and Mental Health Services Administration, Rockville, Maryland.<br /><searchLink fieldCode="AU" term="%22Natarajan+S%22">Natarajan S</searchLink>; VA New York Harbor Healthcare System, Brooklyn.<br /><searchLink fieldCode="AU" term="%22Malhotra+AK%22">Malhotra AK</searchLink>; Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, New York.; Division of Psychiatry Research, The Zucker Hillside Hospital, Northwell Health, Glen Oaks, New York.; Department of Psychiatry, Hofstra Northwell School of Medicine, Hempstead, New York.<br /><searchLink fieldCode="AU" term="%22Shi+Y%22">Shi Y</searchLink>; Massachusetts Area Veterans Epidemiology, Research, and Information Center (MAVERIC), Jamaica Plain.<br /><searchLink fieldCode="AU" term="%22Zhao+H%22">Zhao H</searchLink>; Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, Connecticut.; Yale University School of Medicine, New Haven, Connecticut.<br /><searchLink fieldCode="AU" term="%22Kosten+TR%22">Kosten TR</searchLink>; Michael E. DeBakey VA Medical Center, Houston, Texas.; Department of Psychiatry, Neuroscience, Pharmacology, and Immunology and Rheumatology, Baylor College of Medicine, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22Concato+J%22">Concato J</searchLink>; Yale University School of Medicine, New Haven, Connecticut.; Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland.<br /><searchLink fieldCode="AU" term="%22O'Leary+TJ%22">O'Leary TJ</searchLink>; Office of Research and Development, Veterans Health Administration, Washington, DC.<br /><searchLink fieldCode="AU" term="%22Przygodzki+R%22">Przygodzki R</searchLink>; Office of Research and Development, Veterans Health Administration, Washington, DC.<br /><searchLink fieldCode="AU" term="%22Gleason+T%22">Gleason T</searchLink>; Office of Research and Development, Veterans Health Administration, Washington, DC.<br /><searchLink fieldCode="AU" term="%22Pyarajan+S%22">Pyarajan S</searchLink>; Massachusetts Area Veterans Epidemiology, Research, and Information Center (MAVERIC), Jamaica Plain.<br /><searchLink fieldCode="AU" term="%22Brophy+M%22">Brophy M</searchLink>; Massachusetts Area Veterans Epidemiology, Research, and Information Center (MAVERIC), Jamaica Plain.; Boston University School of Medicine, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Huang+GD%22">Huang GD</searchLink>; Office of Research and Development, Veterans Health Administration, Washington, DC.<br /><searchLink fieldCode="AU" term="%22Muralidhar+S%22">Muralidhar S</searchLink>; Office of Research and Development, Veterans Health Administration, Washington, DC.<br /><searchLink fieldCode="AU" term="%22Gaziano+JM%22">Gaziano JM</searchLink>; Massachusetts Area Veterans Epidemiology, Research, and Information Center (MAVERIC), Jamaica Plain.; Harvard Medical School, Boston, Massachusetts.<br /><searchLink fieldCode="AU" term="%22Aslan+M%22">Aslan M</searchLink>; Clinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, Connecticut.; Yale University School of Medicine, New Haven, Connecticut.<br /><searchLink fieldCode="AU" term="%22Fanous+AH%22">Fanous AH</searchLink>; Department of Psychiatry, University of Arizona College of Medicine-Phoenix, Phoenix.; Carl T. Hayden Veterans Affairs Medical Center, Phoenix, Arizona.<br /><searchLink fieldCode="AU" term="%22Harvey+PD%22">Harvey PD</searchLink>; Bruce W. Carter Miami Veterans Affairs (VA) Medical Center, Miami, Florida.; University of Miami Miller School of Medicine, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Roussos+P%22">Roussos P</searchLink>; James J. Peters Veterans Affairs Medical Center, Bronx, New York.; Departments of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York.; Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.
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