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Transcriptional profiling of matched patient biopsies clarifies molecular determinants of enzalutamide-induced lineage plasticity.

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Title: Transcriptional profiling of matched patient biopsies clarifies molecular determinants of enzalutamide-induced lineage plasticity.
Authors: Westbrook TC; Division of Hematology and Oncology, Department of Internal Medicine, Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Guan X; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA., Rodansky E; Division of Hematology and Oncology, Department of Internal Medicine, Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Flores D; Division of Hematology and Oncology, Department of Internal Medicine, Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Liu CJ; Department of Pathology, Michigan Center for Translational Pathology, Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Udager AM; Department of Pathology, Michigan Center for Translational Pathology, Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Patel RA; Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Haffner MC; Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Hu YM; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA., Sun D; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA., Beer TM; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA., Foye A; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Aggarwal R; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Quigley DA; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Youngren JF; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Ryan CJ; Masonic Cancer Center, University of Minnesota; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA., Gleave M; Department of Urological Sciences and Vancouver Prostate Centre, University of British Columbia, Vancouver, BC, Canada., Wang Y; Department of Urological Sciences and Vancouver Prostate Centre, University of British Columbia, Vancouver, BC, Canada.; Department of Experimental Therapeutics, BC Cancer, University of British Columbia, Vancouver, BC, Canada., Huang J; Duke University, Durham, NC, USA., Coleman I; Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Morrissey C; Department of Urology, University of Washington, Seattle, WA, USA., Nelson PS; Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Evans CP; University of California Davis, Davis, CA, USA., Lara P; University of California Davis, Davis, CA, USA., Reiter RE; University of California Los Angeles, Los Angeles, CA, USA., Witte O; Department of Microbiology, Immunology, and Molecular Genetics at the David Geffen School of Medicine, UCLA, Los Angeles, CA, USA., Rettig M; University of California Los Angeles, Los Angeles, CA, USA.; VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA., Wong CK; UC Santa Cruz Genomics Institute and Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA., Weinstein AS; UC Santa Cruz Genomics Institute and Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA., Uzunangelov V; UC Santa Cruz Genomics Institute and Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA., Stuart JM; UC Santa Cruz Genomics Institute and Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA., Thomas GV; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA., Feng FY; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.; Departments of Radiation Oncology and Urology, University of California San Francisco, San Francisco, CA, USA., Small EJ; Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.; Department of Medicine, University of California San Francisco, San Francisco, CA, USA., Yates JA; Division of Hematology and Oncology, Department of Internal Medicine, Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA., Xia Z; Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA. xiaz@ohsu.edu., Alumkal JJ; Division of Hematology and Oncology, Department of Internal Medicine, Rogel Cancer Center, University of Michigan, Ann Arbor, MI, USA. jalumkal@med.umich.edu.
Source: Nature communications [Nat Commun] 2022 Sep 15; Vol. 13 (1), pp. 5345. Date of Electronic Publication: 2022 Sep 15.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Transcriptional profiling of matched patient biopsies clarifies molecular determinants of enzalutamide-induced lineage plasticity.
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