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Amyloid-Related Imaging Abnormalities in the DIAN-TU-001 Trial of Gantenerumab and Solanezumab: Lessons from a Trial in Dominantly Inherited Alzheimer Disease.

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Title: Amyloid-Related Imaging Abnormalities in the DIAN-TU-001 Trial of Gantenerumab and Solanezumab: Lessons from a Trial in Dominantly Inherited Alzheimer Disease.
Authors: Joseph-Mathurin N; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO., Llibre-Guerra JJ; Department of Neurology, Washington University School of Medicine, St. Louis, MO., Li Y; Department of Neurology, Washington University School of Medicine, St. Louis, MO., McCullough AA; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO., Hofmann C; Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Wojtowicz J; Product Development, Clinical Safety, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Park E; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO., Wang G; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO., Preboske GM; Department of Radiology, Mayo Clinic, Rochester, MN., Wang Q; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO., Gordon BA; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO., Chen CD; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO., Flores S; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO., Aggarwal NT; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL., Berman SB; Departments of Neurology and Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA., Bird TD; Department of Neurology, University of Washington, Seattle, WA., Black SE; Department of Medicine (Neurology), Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada., Borowski B; Department of Radiology, Mayo Clinic, Rochester, MN., Brooks WS; Neuroscience Research Australia, University of New South Wales, New South Wales, Australia., Chhatwal JP; Department of Neurology, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, MA., Clarnette R; Department of Internal Medicine, Medical School, University of Western Australia, Crawley, Australia., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO., Fagan AM; Department of Neurology, Washington University School of Medicine, St. Louis, MO., Farlow M; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN., Fox NC; UCL Queen Square Institute of Neurology, University College London, London, UK., Gauthier S; McGill Center for Studies in Aging, McGill University, Montreal, Quebec, Canada., Hassenstab J; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO.; Psychological and Brain Sciences, Washington University School of Medicine, St. Louis, MO., Hobbs DA; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO., Holdridge KC; Eli Lilly and Company, Indianapolis, IN., Honig LS; Taub Institute, Columbia University Irving Medical Center, New York, NY., Hornbeck RC; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO., Hsiung GR; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Jack CR Jr; Department of Radiology, Mayo Clinic, Rochester, MN., Jimenez-Velazquez IZ; Department of Medicine, University of Puerto Rico School of Medicine, San Juan, PR., Jucker M; German Center for Neurodegenerative Diseases (DZNE), Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Klein G; Clinical Imaging, Biomarkers & Translational Technologies, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Levin J; German Center for Neurodegenerative Diseases (DZNE), Department of Neurology, Ludwig-Maximilians-Universität München, Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Mancini M; Eli Lilly and Company, Indianapolis, IN., Masellis M; Department of Medicine (Neurology), Sunnybrook Health Sciences Centre, Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada., McKay NS; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO., Mummery CJ; UCL Queen Square Institute of Neurology, University College London, London, UK., Ringman JM; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA., Shimada H; Diagnostic and Interventional Radiology, Graduate School of Medicine, Osaka City University, Osaka, Japan., Snider BJ; Department of Neurology, Washington University School of Medicine, St. Louis, MO., Suzuki K; Department of Internal Medicine, National Defense Medical College, Saitama, Japan., Wallon D; INSERM U1245, Normandie University, Rouen, France., Xiong C; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO., Yaari R; Eli Lilly and Company, Indianapolis, IN., McDade E; Department of Neurology, Washington University School of Medicine, St. Louis, MO., Perrin RJ; Department of Neurology, Washington University School of Medicine, St. Louis, MO.; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO., Bateman RJ; Department of Neurology, Washington University School of Medicine, St. Louis, MO., Salloway SP; Department of Neurology, Alpert Medical School of Brown University, Butler Hospital, Providence, RI., Benzinger TLS; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO., Clifford DB; Department of Neurology, Washington University School of Medicine, St. Louis, MO.
Corporate Authors: Dominantly Inherited Alzheimer Network Trials Unit
Source: Annals of neurology [Ann Neurol] 2022 Nov; Vol. 92 (5), pp. 729-744. Date of Electronic Publication: 2022 Oct 13.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7707449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8249 (Electronic) Linking ISSN: 03645134 NLM ISO Abbreviation: Ann Neurol Subsets: MEDLINE
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