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Discovery and molecular basis of subtype-selective cyclophilin inhibitors.

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Title: Discovery and molecular basis of subtype-selective cyclophilin inhibitors.
Authors: Peterson AA; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA., Rangwala AM; Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA., Thakur MK; Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA., Ward PS; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Howard Hughes Medical Institute and Departments of Molecular Biology and Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Hung C; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA., Outhwaite IR; Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA., Chan AI; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA., Usanov DL; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA., Mootha VK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Howard Hughes Medical Institute and Departments of Molecular Biology and Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Seeliger MA; Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA. markus.seeliger@stonybrook.edu., Liu DR; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA. drliu@fas.harvard.edu.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. drliu@fas.harvard.edu.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA. drliu@fas.harvard.edu.
Source: Nature chemical biology [Nat Chem Biol] 2022 Nov; Vol. 18 (11), pp. 1184-1195. Date of Electronic Publication: 2022 Sep 26.
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Peterson+AA%22">Peterson AA</searchLink>; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rangwala+AM%22">Rangwala AM</searchLink>; Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA.<br /><searchLink fieldCode="AU" term="%22Thakur+MK%22">Thakur MK</searchLink>; Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA.<br /><searchLink fieldCode="AU" term="%22Ward+PS%22">Ward PS</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Howard Hughes Medical Institute and Departments of Molecular Biology and Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hung+C%22">Hung C</searchLink>; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Outhwaite+IR%22">Outhwaite IR</searchLink>; Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA.<br /><searchLink fieldCode="AU" term="%22Chan+AI%22">Chan AI</searchLink>; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Usanov+DL%22">Usanov DL</searchLink>; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mootha+VK%22">Mootha VK</searchLink>; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Howard Hughes Medical Institute and Departments of Molecular Biology and Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Seeliger+MA%22">Seeliger MA</searchLink>; Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA. markus.seeliger@stonybrook.edu.<br /><searchLink fieldCode="AU" term="%22Liu+DR%22">Liu DR</searchLink>; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA. drliu@fas.harvard.edu.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. drliu@fas.harvard.edu.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA. drliu@fas.harvard.edu.
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