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TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma.

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Title: TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma.
Authors: Erazo T; Molecular Pharmacology Program, Experimental Therapeutics Center and Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Evans CM; Molecular Pharmacology Program, Experimental Therapeutics Center and Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Pharmacology, Weill Cornell School of Medical Sciences, New York, NY, USA., Zakheim D; Gene Editing and Screening Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chu EL; Molecular Pharmacology Program, Experimental Therapeutics Center and Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Refermat AY; Gene Editing and Screening Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Asgari Z; Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Yang X; Molecular Pharmacology Program, Experimental Therapeutics Center and Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Da Silva Ferreira M; Molecular Pharmacology Program, Experimental Therapeutics Center and Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Mehta S; Gene Editing and Screening Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Russo MV; Gene Editing and Screening Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Knezevic A; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Zhang XP; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA, 19426, USA., Chen Z; Division of Biostatistics and Epidemiology, Weill Cornell Medicine, New York, NY, 10021, USA., Fennell M; Gene Editing and Screening Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Garippa R; Gene Editing and Screening Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Seshan V; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., de Stanchina E; Antitumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Barbash O; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA, 19426, USA., Batlevi CL; Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Leslie CS; Computational Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Melnick AM; Division of Hematology and Medical Oncology, Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Younes A; Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA. anas.younes@astrazeneca.com., Kharas MG; Molecular Pharmacology Program, Experimental Therapeutics Center and Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. kharasm@mskcc.org.
Source: Nature communications [Nat Commun] 2022 Sep 27; Vol. 13 (1), pp. 5676. Date of Electronic Publication: 2022 Sep 27.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma.
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  Data: <searchLink fieldCode="AU" term="%22Erazo+T%22">Erazo T</searchLink>; Molecular Pharmacology Program, Experimental Therapeutics Center and Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Evans+CM%22">Evans CM</searchLink>; Molecular Pharmacology Program, Experimental Therapeutics Center and Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Pharmacology, Weill Cornell School of Medical Sciences, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zakheim+D%22">Zakheim D</searchLink>; Gene Editing and Screening Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Chu+EL%22">Chu EL</searchLink>; Molecular Pharmacology Program, Experimental Therapeutics Center and Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Refermat+AY%22">Refermat AY</searchLink>; Gene Editing and Screening Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Asgari+Z%22">Asgari Z</searchLink>; Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Molecular Pharmacology Program, Experimental Therapeutics Center and Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Da+Silva+Ferreira+M%22">Da Silva Ferreira M</searchLink>; Molecular Pharmacology Program, Experimental Therapeutics Center and Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Mehta+S%22">Mehta S</searchLink>; Gene Editing and Screening Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Russo+MV%22">Russo MV</searchLink>; Gene Editing and Screening Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Knezevic+A%22">Knezevic A</searchLink>; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+XP%22">Zhang XP</searchLink>; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA, 19426, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Division of Biostatistics and Epidemiology, Weill Cornell Medicine, New York, NY, 10021, USA.<br /><searchLink fieldCode="AU" term="%22Fennell+M%22">Fennell M</searchLink>; Gene Editing and Screening Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Garippa+R%22">Garippa R</searchLink>; Gene Editing and Screening Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Seshan+V%22">Seshan V</searchLink>; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22de+Stanchina+E%22">de Stanchina E</searchLink>; Antitumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Barbash+O%22">Barbash O</searchLink>; Epigenetics Research Unit, GlaxoSmithKline, Collegeville, PA, 19426, USA.<br /><searchLink fieldCode="AU" term="%22Batlevi+CL%22">Batlevi CL</searchLink>; Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Leslie+CS%22">Leslie CS</searchLink>; Computational Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Melnick+AM%22">Melnick AM</searchLink>; Division of Hematology and Medical Oncology, Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Younes+A%22">Younes A</searchLink>; Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA. anas.younes@astrazeneca.com.<br /><searchLink fieldCode="AU" term="%22Kharas+MG%22">Kharas MG</searchLink>; Molecular Pharmacology Program, Experimental Therapeutics Center and Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. kharasm@mskcc.org.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2022 Sep 27; Vol. 13 (1), pp. 5676. <i>Date of Electronic Publication: </i>2022 Sep 27.
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