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Concurrent inhibition of CDK2 adds to the anti-tumour activity of CDK4/6 inhibition in GIST.

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Title: Concurrent inhibition of CDK2 adds to the anti-tumour activity of CDK4/6 inhibition in GIST.
Authors: Schaefer IM; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. ischaefer@bwh.harvard.edu., Hemming ML; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.; Sarcoma Center, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA, USA., Lundberg MZ; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Serrata MP; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Goldaracena I; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Liu N; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Yin P; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA., Paulo JA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Gygi SP; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., George S; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.; Sarcoma Center, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA, USA., Morgan JA; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.; Sarcoma Center, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA, USA., Bertagnolli MM; Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Sicinska ET; Department of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Chu C; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Zheng S; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Mariño-Enríquez A; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Hornick JL; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Sarcoma Center, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA, USA., Raut CP; Sarcoma Center, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA, USA.; Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Ou WB; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China., Demetri GD; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.; Sarcoma Center, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA, USA.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA., Saka SK; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany., Fletcher JA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Sarcoma Center, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA, USA.
Source: British journal of cancer [Br J Cancer] 2022 Nov; Vol. 127 (11), pp. 2072-2085. Date of Electronic Publication: 2022 Sep 29.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group on behalf of Cancer Research UK Country of Publication: England NLM ID: 0370635 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1827 (Electronic) Linking ISSN: 00070920 NLM ISO Abbreviation: Br J Cancer Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Schaefer+IM%22">Schaefer IM</searchLink>; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. ischaefer@bwh.harvard.edu.<br /><searchLink fieldCode="AU" term="%22Hemming+ML%22">Hemming ML</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.; Sarcoma Center, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lundberg+MZ%22">Lundberg MZ</searchLink>; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Serrata+MP%22">Serrata MP</searchLink>; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Goldaracena+I%22">Goldaracena I</searchLink>; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Liu+N%22">Liu N</searchLink>; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Yin+P%22">Yin P</searchLink>; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Paulo+JA%22">Paulo JA</searchLink>; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gygi+SP%22">Gygi SP</searchLink>; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22George+S%22">George S</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.; Sarcoma Center, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Morgan+JA%22">Morgan JA</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.; Sarcoma Center, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bertagnolli+MM%22">Bertagnolli MM</searchLink>; Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Sicinska+ET%22">Sicinska ET</searchLink>; Department of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chu+C%22">Chu C</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Zheng+S%22">Zheng S</searchLink>; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mariño-Enríquez+A%22">Mariño-Enríquez A</searchLink>; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hornick+JL%22">Hornick JL</searchLink>; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Sarcoma Center, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Raut+CP%22">Raut CP</searchLink>; Sarcoma Center, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA, USA.; Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ou+WB%22">Ou WB</searchLink>; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Demetri+GD%22">Demetri GD</searchLink>; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.; Sarcoma Center, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA, USA.; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Saka+SK%22">Saka SK</searchLink>; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA.; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Fletcher+JA%22">Fletcher JA</searchLink>; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Sarcoma Center, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA, USA.
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