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Genetic alterations of TP53 and OTX2 indicate increased risk of relapse in WNT medulloblastomas.

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Title: Genetic alterations of TP53 and OTX2 indicate increased risk of relapse in WNT medulloblastomas.
Authors: Goschzik T; Department of Neuropathology and DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Venusberg-Campus 1, D-53127, Bonn, Germany., Mynarek M; Department of Pediatric Hematology/Oncology, University Clinics Hamburg-Eppendorf, Hamburg, Germany.; Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Doerner E; Department of Neuropathology and DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Venusberg-Campus 1, D-53127, Bonn, Germany., Schenk A; Institute of Medical Biometry, Informatics and Epidemiology, Medical Faculty, University of Bonn, Bonn, Germany., Spier I; Institute of Human Genetics and Center for Hereditary Tumor Syndromes, Medical Faculty, University of Bonn, Bonn, Germany., Warmuth-Metz M; Institute of Diagnostic and Interventional Neuroradiology, University Hospital Wuerzburg, Würzburg, Germany., Bison B; Department of Neuroradiology, University Hospital, Augsburg, Germany., Obrecht D; Department of Pediatric Hematology/Oncology, University Clinics Hamburg-Eppendorf, Hamburg, Germany., Struve N; Department of Radiotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Kortmann RD; Department of Radiation Oncology, University of Leipzig, Leipzig, Germany., Schmid M; Institute of Medical Biometry, Informatics and Epidemiology, Medical Faculty, University of Bonn, Bonn, Germany., Aretz S; Institute of Human Genetics and Center for Hereditary Tumor Syndromes, Medical Faculty, University of Bonn, Bonn, Germany., Rutkowski S; Department of Pediatric Hematology/Oncology, University Clinics Hamburg-Eppendorf, Hamburg, Germany., Pietsch T; Department of Neuropathology and DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Venusberg-Campus 1, D-53127, Bonn, Germany. t.pietsch@uni-bonn.de.
Source: Acta neuropathologica [Acta Neuropathol] 2022 Dec; Vol. 144 (6), pp. 1143-1156. Date of Electronic Publication: 2022 Oct 01.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Genetic alterations of TP53 and OTX2 indicate increased risk of relapse in WNT medulloblastomas.
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  Data: <searchLink fieldCode="AU" term="%22Goschzik+T%22">Goschzik T</searchLink>; Department of Neuropathology and DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Venusberg-Campus 1, D-53127, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Mynarek+M%22">Mynarek M</searchLink>; Department of Pediatric Hematology/Oncology, University Clinics Hamburg-Eppendorf, Hamburg, Germany.; Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Doerner+E%22">Doerner E</searchLink>; Department of Neuropathology and DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Venusberg-Campus 1, D-53127, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Schenk+A%22">Schenk A</searchLink>; Institute of Medical Biometry, Informatics and Epidemiology, Medical Faculty, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Spier+I%22">Spier I</searchLink>; Institute of Human Genetics and Center for Hereditary Tumor Syndromes, Medical Faculty, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Warmuth-Metz+M%22">Warmuth-Metz M</searchLink>; Institute of Diagnostic and Interventional Neuroradiology, University Hospital Wuerzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Bison+B%22">Bison B</searchLink>; Department of Neuroradiology, University Hospital, Augsburg, Germany.<br /><searchLink fieldCode="AU" term="%22Obrecht+D%22">Obrecht D</searchLink>; Department of Pediatric Hematology/Oncology, University Clinics Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Struve+N%22">Struve N</searchLink>; Department of Radiotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Kortmann+RD%22">Kortmann RD</searchLink>; Department of Radiation Oncology, University of Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Schmid+M%22">Schmid M</searchLink>; Institute of Medical Biometry, Informatics and Epidemiology, Medical Faculty, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Aretz+S%22">Aretz S</searchLink>; Institute of Human Genetics and Center for Hereditary Tumor Syndromes, Medical Faculty, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Rutkowski+S%22">Rutkowski S</searchLink>; Department of Pediatric Hematology/Oncology, University Clinics Hamburg-Eppendorf, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Pietsch+T%22">Pietsch T</searchLink>; Department of Neuropathology and DGNN Brain Tumor Reference Center, University of Bonn Medical Center, Venusberg-Campus 1, D-53127, Bonn, Germany. t.pietsch@uni-bonn.de.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Verlag%22">Springer Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0412041 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-0533 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200016322%22">00016322 </searchLink><i>NLM ISO Abbreviation: </i>Acta Neuropathol <i>Subsets: </i>MEDLINE
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              Text: 2022 Dec
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