A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction.

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Title: A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction.
Authors: Happ JT; Department of Oncological Sciences, Department of Biochemistry, and Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, UT, USA., Arveseth CD; Department of Oncological Sciences, Department of Biochemistry, and Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, UT, USA.; Washington University School of Medicine, St. Louis, MO, USA., Bruystens J; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA., Bertinetti D; Institute for Biology, Department of Biochemistry, University of Kassel, Kassel, Germany., Nelson IB; Department of Oncological Sciences, Department of Biochemistry, and Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, UT, USA., Olivieri C; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA., Zhang J; Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, CA, USA., Hedeen DS; Department of Oncological Sciences, Department of Biochemistry, and Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, UT, USA., Zhu JF; Department of Oncological Sciences, Department of Biochemistry, and Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, UT, USA., Capener JL; Department of Oncological Sciences, Department of Biochemistry, and Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, UT, USA.; Biological and Biomedical Sciences Program, University of North Carolina, Chapel Hill, NC, USA., Bröckel JW; Institute for Biology, Department of Biochemistry, University of Kassel, Kassel, Germany., Vu L; Department of Neurobiology, University of California, San Diego, La Jolla, CA, USA., King CC; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA., Ruiz-Perez VL; Instituto de Investigaciones Biomédicas 'Alberto Sols,' Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid, Madrid, Spain.; CIBER de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III (ISCIII), Madrid, Spain., Ge X; Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, CA, USA., Veglia G; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA., Herberg FW; Institute for Biology, Department of Biochemistry, University of Kassel, Kassel, Germany., Taylor SS; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA. staylor@ucsd.edu.; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA. staylor@ucsd.edu., Myers BR; Department of Oncological Sciences, Department of Biochemistry, and Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, UT, USA. benjamin.myers@hci.utah.edu.
Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2022 Oct; Vol. 29 (10), pp. 990-999. Date of Electronic Publication: 2022 Oct 06.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1545-9985
DOI:10.1038/s41594-022-00838-z