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A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction.

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Title: A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction.
Authors: Happ JT; Department of Oncological Sciences, Department of Biochemistry, and Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, UT, USA., Arveseth CD; Department of Oncological Sciences, Department of Biochemistry, and Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, UT, USA.; Washington University School of Medicine, St. Louis, MO, USA., Bruystens J; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA., Bertinetti D; Institute for Biology, Department of Biochemistry, University of Kassel, Kassel, Germany., Nelson IB; Department of Oncological Sciences, Department of Biochemistry, and Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, UT, USA., Olivieri C; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA., Zhang J; Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, CA, USA., Hedeen DS; Department of Oncological Sciences, Department of Biochemistry, and Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, UT, USA., Zhu JF; Department of Oncological Sciences, Department of Biochemistry, and Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, UT, USA., Capener JL; Department of Oncological Sciences, Department of Biochemistry, and Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, UT, USA.; Biological and Biomedical Sciences Program, University of North Carolina, Chapel Hill, NC, USA., Bröckel JW; Institute for Biology, Department of Biochemistry, University of Kassel, Kassel, Germany., Vu L; Department of Neurobiology, University of California, San Diego, La Jolla, CA, USA., King CC; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA., Ruiz-Perez VL; Instituto de Investigaciones Biomédicas 'Alberto Sols,' Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid, Madrid, Spain.; CIBER de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III (ISCIII), Madrid, Spain., Ge X; Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, CA, USA., Veglia G; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA., Herberg FW; Institute for Biology, Department of Biochemistry, University of Kassel, Kassel, Germany., Taylor SS; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA. staylor@ucsd.edu.; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA. staylor@ucsd.edu., Myers BR; Department of Oncological Sciences, Department of Biochemistry, and Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, UT, USA. benjamin.myers@hci.utah.edu.
Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2022 Oct; Vol. 29 (10), pp. 990-999. Date of Electronic Publication: 2022 Oct 06.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE
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  Data: A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction.
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  Data: <searchLink fieldCode="AU" term="%22Happ+JT%22">Happ JT</searchLink>; Department of Oncological Sciences, Department of Biochemistry, and Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Arveseth+CD%22">Arveseth CD</searchLink>; Department of Oncological Sciences, Department of Biochemistry, and Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, UT, USA.; Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Bruystens+J%22">Bruystens J</searchLink>; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Bertinetti+D%22">Bertinetti D</searchLink>; Institute for Biology, Department of Biochemistry, University of Kassel, Kassel, Germany.<br /><searchLink fieldCode="AU" term="%22Nelson+IB%22">Nelson IB</searchLink>; Department of Oncological Sciences, Department of Biochemistry, and Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Olivieri+C%22">Olivieri C</searchLink>; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, CA, USA.<br /><searchLink fieldCode="AU" term="%22Hedeen+DS%22">Hedeen DS</searchLink>; Department of Oncological Sciences, Department of Biochemistry, and Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+JF%22">Zhu JF</searchLink>; Department of Oncological Sciences, Department of Biochemistry, and Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Capener+JL%22">Capener JL</searchLink>; Department of Oncological Sciences, Department of Biochemistry, and Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, UT, USA.; Biological and Biomedical Sciences Program, University of North Carolina, Chapel Hill, NC, USA.<br /><searchLink fieldCode="AU" term="%22Bröckel+JW%22">Bröckel JW</searchLink>; Institute for Biology, Department of Biochemistry, University of Kassel, Kassel, Germany.<br /><searchLink fieldCode="AU" term="%22Vu+L%22">Vu L</searchLink>; Department of Neurobiology, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22King+CC%22">King CC</searchLink>; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ruiz-Perez+VL%22">Ruiz-Perez VL</searchLink>; Instituto de Investigaciones Biomédicas 'Alberto Sols,' Consejo Superior de Investigaciones Científicas (CSIC), Universidad Autónoma de Madrid, Madrid, Spain.; CIBER de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Ge+X%22">Ge X</searchLink>; Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, CA, USA.<br /><searchLink fieldCode="AU" term="%22Veglia+G%22">Veglia G</searchLink>; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Herberg+FW%22">Herberg FW</searchLink>; Institute for Biology, Department of Biochemistry, University of Kassel, Kassel, Germany.<br /><searchLink fieldCode="AU" term="%22Taylor+SS%22">Taylor SS</searchLink>; Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA. staylor@ucsd.edu.; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA. staylor@ucsd.edu.<br /><searchLink fieldCode="AU" term="%22Myers+BR%22">Myers BR</searchLink>; Department of Oncological Sciences, Department of Biochemistry, and Department of Bioengineering, University of Utah School of Medicine, Salt Lake City, UT, USA. benjamin.myers@hci.utah.edu.
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  Data: <searchLink fieldCode="JN" term="%22101186374%22">Nature structural & molecular biology</searchLink> [Nat Struct Mol Biol] 2022 Oct; Vol. 29 (10), pp. 990-999. <i>Date of Electronic Publication: </i>2022 Oct 06.
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