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Discovery and Biological Characterization of PRMT5:MEP50 Protein-Protein Interaction Inhibitors.

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Title: Discovery and Biological Characterization of PRMT5:MEP50 Protein-Protein Interaction Inhibitors.
Authors: Asberry AM; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States.; Purdue University Interdisciplinary Life Sciences Graduate Program, Purdue University, West Lafayette, Indiana 47907, United States., Cai X; Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States., Deng X; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States., Santiago U; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States., Liu S; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.; The Indiana University Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana 46202, United States., Sims HS; Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States., Liang W; Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States., Xu X; Department of Biological Sciences, Purdue University, 240 S Martin Jischke Drive, West Lafayette, Indiana 47907, United States., Wan J; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.; The Indiana University Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana 46202, United States.; The Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States., Jiang W; Department of Biological Sciences, Purdue University, 240 S Martin Jischke Drive, West Lafayette, Indiana 47907, United States.; Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United States., Camacho CJ; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States., Dai M; Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.; Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United States.; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States., Hu CD; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States.; Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2022 Oct 27; Vol. 65 (20), pp. 13793-13812. Date of Electronic Publication: 2022 Oct 07.
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Discovery and Biological Characterization of PRMT5:MEP50 Protein-Protein Interaction Inhibitors.
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  Data: <searchLink fieldCode="AU" term="%22Asberry+AM%22">Asberry AM</searchLink>; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States.; Purdue University Interdisciplinary Life Sciences Graduate Program, Purdue University, West Lafayette, Indiana 47907, United States.<br /><searchLink fieldCode="AU" term="%22Cai+X%22">Cai X</searchLink>; Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.<br /><searchLink fieldCode="AU" term="%22Deng+X%22">Deng X</searchLink>; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States.<br /><searchLink fieldCode="AU" term="%22Santiago+U%22">Santiago U</searchLink>; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.; The Indiana University Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana 46202, United States.<br /><searchLink fieldCode="AU" term="%22Sims+HS%22">Sims HS</searchLink>; Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.<br /><searchLink fieldCode="AU" term="%22Liang+W%22">Liang W</searchLink>; Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.<br /><searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; Department of Biological Sciences, Purdue University, 240 S Martin Jischke Drive, West Lafayette, Indiana 47907, United States.<br /><searchLink fieldCode="AU" term="%22Wan+J%22">Wan J</searchLink>; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.; The Indiana University Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana 46202, United States.; The Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.<br /><searchLink fieldCode="AU" term="%22Jiang+W%22">Jiang W</searchLink>; Department of Biological Sciences, Purdue University, 240 S Martin Jischke Drive, West Lafayette, Indiana 47907, United States.; Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United States.<br /><searchLink fieldCode="AU" term="%22Camacho+CJ%22">Camacho CJ</searchLink>; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.<br /><searchLink fieldCode="AU" term="%22Dai+M%22">Dai M</searchLink>; Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States.; Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United States.; Department of Chemistry, Emory University, Atlanta, Georgia 30322, United States.<br /><searchLink fieldCode="AU" term="%22Hu+CD%22">Hu CD</searchLink>; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907, United States.; Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2022 Oct 27; Vol. 65 (20), pp. 13793-13812. <i>Date of Electronic Publication: </i>2022 Oct 07.
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        Value: 10.1021/acs.jmedchem.2c01000
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              Text: 2022 Oct 27
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