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Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease.

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Title: Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease.
Authors: Song J; The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Yang RR; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.; Shanghai Institute for Advanced Immunochemical Studies, and School of Life Science and Technology, Shanghai Tech University, Shanghai, 200031, China., Chang J; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China., Liu YD; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China., Lu CH; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China., Chen LF; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Guo H; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Zhang YH; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China., Fan ZS; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China., Zhou JY; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China., Zhou GZ; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China., Zhang KK; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China., Luo XM; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China., Chen KX; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China., Jiang HL; The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China. hljiang@simm.ac.cn.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. hljiang@simm.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. hljiang@simm.ac.cn.; Shanghai Institute for Advanced Immunochemical Studies, and School of Life Science and Technology, Shanghai Tech University, Shanghai, 200031, China. hljiang@simm.ac.cn.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China. hljiang@simm.ac.cn., Zhang SL; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. slzhang@simm.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. slzhang@simm.ac.cn., Zheng MY; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. myzheng@simm.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. myzheng@simm.ac.cn.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China. myzheng@simm.ac.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2023 Apr; Vol. 44 (4), pp. 791-800. Date of Electronic Publication: 2022 Oct 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Discovery and characterization of a novel cGAS covalent inhibitor for the treatment of inflammatory bowel disease.
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  Data: <searchLink fieldCode="AU" term="%22Song+J%22">Song J</searchLink>; The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Yang+RR%22">Yang RR</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.; Shanghai Institute for Advanced Immunochemical Studies, and School of Life Science and Technology, Shanghai Tech University, Shanghai, 200031, China.<br /><searchLink fieldCode="AU" term="%22Chang+J%22">Chang J</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.<br /><searchLink fieldCode="AU" term="%22Liu+YD%22">Liu YD</searchLink>; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.<br /><searchLink fieldCode="AU" term="%22Lu+CH%22">Lu CH</searchLink>; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.<br /><searchLink fieldCode="AU" term="%22Chen+LF%22">Chen LF</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Guo+H%22">Guo H</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Zhang+YH%22">Zhang YH</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.<br /><searchLink fieldCode="AU" term="%22Fan+ZS%22">Fan ZS</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.<br /><searchLink fieldCode="AU" term="%22Zhou+JY%22">Zhou JY</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.<br /><searchLink fieldCode="AU" term="%22Zhou+GZ%22">Zhou GZ</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.<br /><searchLink fieldCode="AU" term="%22Zhang+KK%22">Zhang KK</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.<br /><searchLink fieldCode="AU" term="%22Luo+XM%22">Luo XM</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.<br /><searchLink fieldCode="AU" term="%22Chen+KX%22">Chen KX</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.; University of Chinese Academy of Sciences, Beijing, 100049, China.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.<br /><searchLink fieldCode="AU" term="%22Jiang+HL%22">Jiang HL</searchLink>; The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China. hljiang@simm.ac.cn.; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. hljiang@simm.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. hljiang@simm.ac.cn.; Shanghai Institute for Advanced Immunochemical Studies, and School of Life Science and Technology, Shanghai Tech University, Shanghai, 200031, China. hljiang@simm.ac.cn.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China. hljiang@simm.ac.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+SL%22">Zhang SL</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. slzhang@simm.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. slzhang@simm.ac.cn.<br /><searchLink fieldCode="AU" term="%22Zheng+MY%22">Zheng MY</searchLink>; Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. myzheng@simm.ac.cn.; University of Chinese Academy of Sciences, Beijing, 100049, China. myzheng@simm.ac.cn.; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China. myzheng@simm.ac.cn.
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  Data: <searchLink fieldCode="JN" term="%22100956087%22">Acta pharmacologica Sinica</searchLink> [Acta Pharmacol Sin] 2023 Apr; Vol. 44 (4), pp. 791-800. <i>Date of Electronic Publication: </i>2022 Oct 13.
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        Value: 10.1038/s41401-022-01002-5
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        Text: English
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              Text: 2023 Apr
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