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Pharmacokinetics, bioavailability, and plasma protein binding study of glytrexate, a novel multitarget antifolate.

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Title: Pharmacokinetics, bioavailability, and plasma protein binding study of glytrexate, a novel multitarget antifolate.
Authors: Xiang J; Key Laboratory of Innovative Drug Research and Evaluation in Hebei Province, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China., Wu M; Key Laboratory of Innovative Drug Research and Evaluation in Hebei Province, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China., Wang J; Key Laboratory of Innovative Drug Research and Evaluation in Hebei Province, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China., Lin M; Key Laboratory of Innovative Drug Research and Evaluation in Hebei Province, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China., Sun M; Department of General Practice, The Second Hospital, Hebei Medical University, Shijiazhuang, China., Li X; Key Laboratory of Innovative Drug Research and Evaluation in Hebei Province, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China., Xing R; Key Laboratory of Innovative Drug Research and Evaluation in Hebei Province, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China., Guo R; Key Laboratory of Innovative Drug Research and Evaluation in Hebei Province, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China., Gu J; Key Laboratory of Innovative Drug Research and Evaluation in Hebei Province, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China., Lyu T; Key Laboratory of Innovative Drug Research and Evaluation in Hebei Province, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China., Wang L; Key Laboratory of Innovative Drug Research and Evaluation in Hebei Province, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China., Shi X; Key Laboratory of Innovative Drug Research and Evaluation in Hebei Province, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.
Source: Frontiers in pharmacology [Front Pharmacol] 2022 Oct 04; Vol. 13, pp. 1001308. Date of Electronic Publication: 2022 Oct 04 (Print Publication: 2022).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
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  Data: Pharmacokinetics, bioavailability, and plasma protein binding study of glytrexate, a novel multitarget antifolate.
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  Data: <searchLink fieldCode="AU" term="%22Xiang+J%22">Xiang J</searchLink>; Key Laboratory of Innovative Drug Research and Evaluation in Hebei Province, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.<br /><searchLink fieldCode="AU" term="%22Wu+M%22">Wu M</searchLink>; Key Laboratory of Innovative Drug Research and Evaluation in Hebei Province, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Key Laboratory of Innovative Drug Research and Evaluation in Hebei Province, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.<br /><searchLink fieldCode="AU" term="%22Lin+M%22">Lin M</searchLink>; Key Laboratory of Innovative Drug Research and Evaluation in Hebei Province, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.<br /><searchLink fieldCode="AU" term="%22Sun+M%22">Sun M</searchLink>; Department of General Practice, The Second Hospital, Hebei Medical University, Shijiazhuang, China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Key Laboratory of Innovative Drug Research and Evaluation in Hebei Province, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.<br /><searchLink fieldCode="AU" term="%22Xing+R%22">Xing R</searchLink>; Key Laboratory of Innovative Drug Research and Evaluation in Hebei Province, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.<br /><searchLink fieldCode="AU" term="%22Guo+R%22">Guo R</searchLink>; Key Laboratory of Innovative Drug Research and Evaluation in Hebei Province, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.<br /><searchLink fieldCode="AU" term="%22Gu+J%22">Gu J</searchLink>; Key Laboratory of Innovative Drug Research and Evaluation in Hebei Province, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.<br /><searchLink fieldCode="AU" term="%22Lyu+T%22">Lyu T</searchLink>; Key Laboratory of Innovative Drug Research and Evaluation in Hebei Province, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Key Laboratory of Innovative Drug Research and Evaluation in Hebei Province, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.<br /><searchLink fieldCode="AU" term="%22Shi+X%22">Shi X</searchLink>; Key Laboratory of Innovative Drug Research and Evaluation in Hebei Province, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, China.
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  Data: <searchLink fieldCode="JN" term="%22101548923%22">Frontiers in pharmacology</searchLink> [Front Pharmacol] 2022 Oct 04; Vol. 13, pp. 1001308. <i>Date of Electronic Publication: </i>2022 Oct 04 (<i>Print Publication: </i>2022).
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