Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial.
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| Title: | Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial. |
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| Authors: | Khoo SH; Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK; Tropical and Infectious Disease Unit, Liverpool University Hospital NHS Foundation Trust, Liverpool, UK. Electronic address: khoo@liverpool.ac.uk., FitzGerald R; Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK; NIHR Royal Liverpool and Broadgreen Clinical Research Facility, Liverpool University Hospital NHS Foundation Trust, Liverpool, UK., Saunders G; Southampton Clinical Trials Unit, University of Southampton, Southampton, UK., Middleton C; Southampton Clinical Trials Unit, University of Southampton, Southampton, UK., Ahmad S; NIHR Manchester Clinical Research Facility, Manchester University NHS Foundation Trust, Manchester, UK., Edwards CJ; Human Development and Health School, University of Southampton, Southampton, UK; NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Hadjiyiannakis D; NIHR Lancashire Clinical Research Facility, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK., Walker L; Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK; NIHR Royal Liverpool and Broadgreen Clinical Research Facility, Liverpool University Hospital NHS Foundation Trust, Liverpool, UK., Lyon R; NIHR Royal Liverpool and Broadgreen Clinical Research Facility, Liverpool University Hospital NHS Foundation Trust, Liverpool, UK., Shaw V; Clinical Directorate, University of Liverpool, Liverpool, UK., Mozgunov P; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK., Periselneris J; NIHR Kings Clinical Research Facility, King's College Hospital NHS Foundation Trust, London, UK., Woods C; NIHR Royal Liverpool and Broadgreen Clinical Research Facility, Liverpool University Hospital NHS Foundation Trust, Liverpool, UK., Bullock K; Molecular & Clinical Cancer Medicine, University of Liverpool, Liverpool, UK., Hale C; NIHR Royal Liverpool and Broadgreen Clinical Research Facility, Liverpool University Hospital NHS Foundation Trust, Liverpool, UK., Reynolds H; Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK., Downs N; Southampton Clinical Trials Unit, University of Southampton, Southampton, UK., Ewings S; Southampton Clinical Trials Unit, University of Southampton, Southampton, UK., Buadi A; NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Cameron D; NIHR Lancashire Clinical Research Facility, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK., Edwards T; Centre for Drugs and Diagnostics, Liverpool, UK., Knox E; Southampton Clinical Trials Unit, University of Southampton, Southampton, UK., Donovan-Banfield I; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; National Institute of Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, Liverpool, UK., Greenhalf W; Molecular & Clinical Cancer Medicine, University of Liverpool, Liverpool, UK., Chiong J; Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK., Lavelle-Langham L; Molecular & Clinical Cancer Medicine, University of Liverpool, Liverpool, UK., Jacobs M; Infectious Diseases, Royal Free London NHS Foundation Trust, London, UK., Northey J; Southampton Clinical Trials Unit, University of Southampton, Southampton, UK., Painter W; Ridgeback Biotherapeutics, Miami, FL, USA., Holman W; Ridgeback Biotherapeutics, Miami, FL, USA., Lalloo DG; Liverpool School of Tropical Medicine, Liverpool, UK., Tetlow M; Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK., Hiscox JA; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; National Institute of Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, Liverpool, UK., Jaki T; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK; Computational Statistics, University of Regensburg, Regensburg, Germany., Fletcher T; Tropical and Infectious Disease Unit, Liverpool University Hospital NHS Foundation Trust, Liverpool, UK; Clinical Sciences, Liverpool, UK., Griffiths G; Southampton Clinical Trials Unit, University of Southampton, Southampton, UK. |
| Corporate Authors: | AGILE CST-2 Study Group |
| Source: | The Lancet. Infectious diseases [Lancet Infect Dis] 2023 Feb; Vol. 23 (2), pp. 183-195. Date of Electronic Publication: 2022 Oct 19. |
| Publication Type: | Randomized Controlled Trial; Clinical Trial, Phase II; Journal Article; Research Support, U.S. Gov't, P.H.S.; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 101130150 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-4457 (Electronic) Linking ISSN: 14733099 NLM ISO Abbreviation: Lancet Infect Dis Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 36272432 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Khoo+SH%22">Khoo SH</searchLink>; Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK; Tropical and Infectious Disease Unit, Liverpool University Hospital NHS Foundation Trust, Liverpool, UK. Electronic address: khoo@liverpool.ac.uk.<br /><searchLink fieldCode="AU" term="%22FitzGerald+R%22">FitzGerald R</searchLink>; Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK; NIHR Royal Liverpool and Broadgreen Clinical Research Facility, Liverpool University Hospital NHS Foundation Trust, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Saunders+G%22">Saunders G</searchLink>; Southampton Clinical Trials Unit, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Middleton+C%22">Middleton C</searchLink>; Southampton Clinical Trials Unit, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Ahmad+S%22">Ahmad S</searchLink>; NIHR Manchester Clinical Research Facility, Manchester University NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Edwards+CJ%22">Edwards CJ</searchLink>; Human Development and Health School, University of Southampton, Southampton, UK; NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Hadjiyiannakis+D%22">Hadjiyiannakis D</searchLink>; NIHR Lancashire Clinical Research Facility, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK.<br /><searchLink fieldCode="AU" term="%22Walker+L%22">Walker L</searchLink>; Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK; NIHR Royal Liverpool and Broadgreen Clinical Research Facility, Liverpool University Hospital NHS Foundation Trust, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Lyon+R%22">Lyon R</searchLink>; NIHR Royal Liverpool and Broadgreen Clinical Research Facility, Liverpool University Hospital NHS Foundation Trust, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Shaw+V%22">Shaw V</searchLink>; Clinical Directorate, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Mozgunov+P%22">Mozgunov P</searchLink>; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Periselneris+J%22">Periselneris J</searchLink>; NIHR Kings Clinical Research Facility, King's College Hospital NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Woods+C%22">Woods C</searchLink>; NIHR Royal Liverpool and Broadgreen Clinical Research Facility, Liverpool University Hospital NHS Foundation Trust, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Bullock+K%22">Bullock K</searchLink>; Molecular & Clinical Cancer Medicine, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Hale+C%22">Hale C</searchLink>; NIHR Royal Liverpool and Broadgreen Clinical Research Facility, Liverpool University Hospital NHS Foundation Trust, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Reynolds+H%22">Reynolds H</searchLink>; Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Downs+N%22">Downs N</searchLink>; Southampton Clinical Trials Unit, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Ewings+S%22">Ewings S</searchLink>; Southampton Clinical Trials Unit, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Buadi+A%22">Buadi A</searchLink>; NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Cameron+D%22">Cameron D</searchLink>; NIHR Lancashire Clinical Research Facility, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK.<br /><searchLink fieldCode="AU" term="%22Edwards+T%22">Edwards T</searchLink>; Centre for Drugs and Diagnostics, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Knox+E%22">Knox E</searchLink>; Southampton Clinical Trials Unit, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Donovan-Banfield+I%22">Donovan-Banfield I</searchLink>; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; National Institute of Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Greenhalf+W%22">Greenhalf W</searchLink>; Molecular & Clinical Cancer Medicine, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Chiong+J%22">Chiong J</searchLink>; Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Lavelle-Langham+L%22">Lavelle-Langham L</searchLink>; Molecular & Clinical Cancer Medicine, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Jacobs+M%22">Jacobs M</searchLink>; Infectious Diseases, Royal Free London NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Northey+J%22">Northey J</searchLink>; Southampton Clinical Trials Unit, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Painter+W%22">Painter W</searchLink>; Ridgeback Biotherapeutics, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Holman+W%22">Holman W</searchLink>; Ridgeback Biotherapeutics, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Lalloo+DG%22">Lalloo DG</searchLink>; Liverpool School of Tropical Medicine, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Tetlow+M%22">Tetlow M</searchLink>; Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Hiscox+JA%22">Hiscox JA</searchLink>; Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK; National Institute of Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Jaki+T%22">Jaki T</searchLink>; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK; Computational Statistics, University of Regensburg, Regensburg, Germany.<br /><searchLink fieldCode="AU" term="%22Fletcher+T%22">Fletcher T</searchLink>; Tropical and Infectious Disease Unit, Liverpool University Hospital NHS Foundation Trust, Liverpool, UK; Clinical Sciences, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Griffiths+G%22">Griffiths G</searchLink>; Southampton Clinical Trials Unit, University of Southampton, Southampton, UK. – Name: AuthorCorporate Label: Corporate Authors Group: Au Data: <searchLink fieldCode="CA" term="%22AGILE+CST-2+Study+Group%22">AGILE CST-2 Study Group</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101130150%22">The Lancet. Infectious diseases</searchLink> [Lancet Infect Dis] 2023 Feb; Vol. 23 (2), pp. 183-195. <i>Date of Electronic Publication: </i>2022 Oct 19. – Name: TypePub Label: Publication Type Group: TypPub Data: Randomized Controlled Trial; Clinical Trial, Phase II; Journal Article; Research Support, U.S. Gov't, P.H.S.; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101130150 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-4457 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214733099%22">14733099 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Infect Dis <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=36272432 |
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