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CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states.

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Title: CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states.
Authors: Leng K; Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA. kun.leng@ucsf.edu.; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA. kun.leng@ucsf.edu.; Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA. kun.leng@ucsf.edu., Rose IVL; Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA.; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA., Kim H; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA., Xia W; Departments of Neurology and Pediatrics, School of Medicine, University of California, San Francisco, San Francisco, CA, USA., Romero-Fernandez W; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA., Rooney B; Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA., Koontz M; Department of Ophthalmology, School of Medicine, University of California, San Francisco, San Francisco, CA, USA., Li E; Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA., Ao Y; Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA, USA., Wang S; Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA, USA., Krawczyk M; Interdepartmental PhD Program in Neuroscience, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Tcw J; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.; Nash Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Goate A; Nash Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Zhang Y; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA., Ullian EM; Department of Ophthalmology, School of Medicine, University of California, San Francisco, San Francisco, CA, USA., Sofroniew MV; Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA, USA., Fancy SPJ; Departments of Neurology and Pediatrics, School of Medicine, University of California, San Francisco, San Francisco, CA, USA., Schrag MS; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA., Lippmann ES; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA., Kampmann M; Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA. martin.kampmann@ucsf.edu.; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA. martin.kampmann@ucsf.edu.; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA. martin.kampmann@ucsf.edu.
Source: Nature neuroscience [Nat Neurosci] 2022 Nov; Vol. 25 (11), pp. 1528-1542. Date of Electronic Publication: 2022 Oct 27.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE
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  Data: CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states.
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  Data: <searchLink fieldCode="AU" term="%22Leng+K%22">Leng K</searchLink>; Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA. kun.leng@ucsf.edu.; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA. kun.leng@ucsf.edu.; Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA. kun.leng@ucsf.edu.<br /><searchLink fieldCode="AU" term="%22Rose+IVL%22">Rose IVL</searchLink>; Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA.; Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kim+H%22">Kim H</searchLink>; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Xia+W%22">Xia W</searchLink>; Departments of Neurology and Pediatrics, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Romero-Fernandez+W%22">Romero-Fernandez W</searchLink>; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Rooney+B%22">Rooney B</searchLink>; Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Koontz+M%22">Koontz M</searchLink>; Department of Ophthalmology, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Li+E%22">Li E</searchLink>; Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ao+Y%22">Ao Y</searchLink>; Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Krawczyk+M%22">Krawczyk M</searchLink>; Interdepartmental PhD Program in Neuroscience, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Tcw+J%22">Tcw J</searchLink>; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.; Nash Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Goate+A%22">Goate A</searchLink>; Nash Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ullian+EM%22">Ullian EM</searchLink>; Department of Ophthalmology, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Sofroniew+MV%22">Sofroniew MV</searchLink>; Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA, USA.<br /><searchLink fieldCode="AU" term="%22Fancy+SPJ%22">Fancy SPJ</searchLink>; Departments of Neurology and Pediatrics, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Schrag+MS%22">Schrag MS</searchLink>; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Lippmann+ES%22">Lippmann ES</searchLink>; Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA.; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.; Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Kampmann+M%22">Kampmann M</searchLink>; Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA. martin.kampmann@ucsf.edu.; Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA. martin.kampmann@ucsf.edu.; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA. martin.kampmann@ucsf.edu.
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  Data: <searchLink fieldCode="JN" term="%229809671%22">Nature neuroscience</searchLink> [Nat Neurosci] 2022 Nov; Vol. 25 (11), pp. 1528-1542. <i>Date of Electronic Publication: </i>2022 Oct 27.
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