View in EDS

Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis.

Saved in:
Bibliographic Details
Title: Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis.
Authors: Futatsugi K; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Cabral S; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Kung DW; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Huard K; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Lee E; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Boehm M; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Bauman J; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Clark RW; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Coffey SB; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Crowley C; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Dechert-Schmitt AM; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Dowling MS; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Dullea R; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Gosset JR; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Kalgutkar AS; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Kou K; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Li Q; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Lian Y; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Loria PM; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Londregan AT; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Niosi M; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Orozco C; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Pettersen JC; Pfizer Inc. Drug Safety R&D, Eastern Point Road, Groton, Connecticut 06340, United States., Pfefferkorn JA; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Polivkova J; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Ross TT; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Sharma R; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Stock IA; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Tesz G; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Wisniewska H; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States., Goodwin B; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States., Price DA; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2022 Nov 24; Vol. 65 (22), pp. 15000-15013. Date of Electronic Publication: 2022 Nov 02.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 36322383
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Futatsugi+K%22">Futatsugi K</searchLink>; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Cabral+S%22">Cabral S</searchLink>; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Kung+DW%22">Kung DW</searchLink>; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Huard+K%22">Huard K</searchLink>; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Lee+E%22">Lee E</searchLink>; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Boehm+M%22">Boehm M</searchLink>; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Bauman+J%22">Bauman J</searchLink>; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Clark+RW%22">Clark RW</searchLink>; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Coffey+SB%22">Coffey SB</searchLink>; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Crowley+C%22">Crowley C</searchLink>; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Dechert-Schmitt+AM%22">Dechert-Schmitt AM</searchLink>; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Dowling+MS%22">Dowling MS</searchLink>; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Dullea+R%22">Dullea R</searchLink>; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Gosset+JR%22">Gosset JR</searchLink>; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Kalgutkar+AS%22">Kalgutkar AS</searchLink>; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Kou+K%22">Kou K</searchLink>; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Lian+Y%22">Lian Y</searchLink>; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Loria+PM%22">Loria PM</searchLink>; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Londregan+AT%22">Londregan AT</searchLink>; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Niosi+M%22">Niosi M</searchLink>; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Orozco+C%22">Orozco C</searchLink>; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Pettersen+JC%22">Pettersen JC</searchLink>; Pfizer Inc. Drug Safety R&D, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Pfefferkorn+JA%22">Pfefferkorn JA</searchLink>; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Polivkova+J%22">Polivkova J</searchLink>; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Ross+TT%22">Ross TT</searchLink>; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Sharma+R%22">Sharma R</searchLink>; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Stock+IA%22">Stock IA</searchLink>; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Tesz+G%22">Tesz G</searchLink>; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Wisniewska+H%22">Wisniewska H</searchLink>; Pfizer Inc. Medicine Design, Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Goodwin+B%22">Goodwin B</searchLink>; Pfizer Inc. Internal Medicine Research Unit, 1 Portland Street, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Price+DA%22">Price DA</searchLink>; Pfizer Inc. Medicine Design, 1 Portland Street, Cambridge, Massachusetts 02139, United States.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2022 Nov 24; Vol. 65 (22), pp. 15000-15013. <i>Date of Electronic Publication: </i>2022 Nov 02.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=36322383
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1021/acs.jmedchem.2c01200
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 15000
    Titles:
      – TitleFull: Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Futatsugi K
      – PersonEntity:
          Name:
            NameFull: Cabral S
      – PersonEntity:
          Name:
            NameFull: Kung DW
      – PersonEntity:
          Name:
            NameFull: Huard K
      – PersonEntity:
          Name:
            NameFull: Lee E
      – PersonEntity:
          Name:
            NameFull: Boehm M
      – PersonEntity:
          Name:
            NameFull: Bauman J
      – PersonEntity:
          Name:
            NameFull: Clark RW
      – PersonEntity:
          Name:
            NameFull: Coffey SB
      – PersonEntity:
          Name:
            NameFull: Crowley C
      – PersonEntity:
          Name:
            NameFull: Dechert-Schmitt AM
      – PersonEntity:
          Name:
            NameFull: Dowling MS
      – PersonEntity:
          Name:
            NameFull: Dullea R
      – PersonEntity:
          Name:
            NameFull: Gosset JR
      – PersonEntity:
          Name:
            NameFull: Kalgutkar AS
      – PersonEntity:
          Name:
            NameFull: Kou K
      – PersonEntity:
          Name:
            NameFull: Li Q
      – PersonEntity:
          Name:
            NameFull: Lian Y
      – PersonEntity:
          Name:
            NameFull: Loria PM
      – PersonEntity:
          Name:
            NameFull: Londregan AT
      – PersonEntity:
          Name:
            NameFull: Niosi M
      – PersonEntity:
          Name:
            NameFull: Orozco C
      – PersonEntity:
          Name:
            NameFull: Pettersen JC
      – PersonEntity:
          Name:
            NameFull: Pfefferkorn JA
      – PersonEntity:
          Name:
            NameFull: Polivkova J
      – PersonEntity:
          Name:
            NameFull: Ross TT
      – PersonEntity:
          Name:
            NameFull: Sharma R
      – PersonEntity:
          Name:
            NameFull: Stock IA
      – PersonEntity:
          Name:
            NameFull: Tesz G
      – PersonEntity:
          Name:
            NameFull: Wisniewska H
      – PersonEntity:
          Name:
            NameFull: Goodwin B
      – PersonEntity:
          Name:
            NameFull: Price DA
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 24
              M: 11
              Text: 2022 Nov 24
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-electronic
              Value: 1520-4804
          Numbering:
            – Type: volume
              Value: 65
            – Type: issue
              Value: 22
          Titles:
            – TitleFull: Journal of medicinal chemistry
              Type: main
ResultId 1