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A Phase 1 First-in-Human Study of FS118, a Tetravalent Bispecific Antibody Targeting LAG-3 and PD-L1 in Patients with Advanced Cancer and PD-L1 Resistance.

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Title: A Phase 1 First-in-Human Study of FS118, a Tetravalent Bispecific Antibody Targeting LAG-3 and PD-L1 in Patients with Advanced Cancer and PD-L1 Resistance.
Authors: Yap TA; University of Texas MD Anderson Cancer Center, Houston, Texas., LoRusso PM; Yale Cancer Center, New Haven, Connecticut., Wong DJ; UCLA Jonsson Comprehensive Cancer Center, Los Angeles California., Hu-Lieskovan S; UCLA Jonsson Comprehensive Cancer Center, Los Angeles California., Papadopoulos KP; South Texas Research Accelerated Therapeutics (START), San Antonio, Texas., Holz JB; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom., Grabowska U; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom., Gradinaru C; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom., Leung KM; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom., Marshall S; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom., Reader CS; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom., Russell R; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom., Sainson RCA; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom., Seal CJ; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom., Shepherd CJ; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom., Germaschewski F; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom., Gliddon D; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom., Stern O; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom., Young L; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom., Brewis N; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom., Kayitalire L; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom., Morrow M; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom.
Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2023 Mar 01; Vol. 29 (5), pp. 888-898.
Publication Type: Research Support, Non-U.S. Gov't; Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: A Phase 1 First-in-Human Study of FS118, a Tetravalent Bispecific Antibody Targeting LAG-3 and PD-L1 in Patients with Advanced Cancer and PD-L1 Resistance.
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  Data: <searchLink fieldCode="AU" term="%22Yap+TA%22">Yap TA</searchLink>; University of Texas MD Anderson Cancer Center, Houston, Texas.<br /><searchLink fieldCode="AU" term="%22LoRusso+PM%22">LoRusso PM</searchLink>; Yale Cancer Center, New Haven, Connecticut.<br /><searchLink fieldCode="AU" term="%22Wong+DJ%22">Wong DJ</searchLink>; UCLA Jonsson Comprehensive Cancer Center, Los Angeles California.<br /><searchLink fieldCode="AU" term="%22Hu-Lieskovan+S%22">Hu-Lieskovan S</searchLink>; UCLA Jonsson Comprehensive Cancer Center, Los Angeles California.<br /><searchLink fieldCode="AU" term="%22Papadopoulos+KP%22">Papadopoulos KP</searchLink>; South Texas Research Accelerated Therapeutics (START), San Antonio, Texas.<br /><searchLink fieldCode="AU" term="%22Holz+JB%22">Holz JB</searchLink>; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Grabowska+U%22">Grabowska U</searchLink>; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gradinaru+C%22">Gradinaru C</searchLink>; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Leung+KM%22">Leung KM</searchLink>; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Marshall+S%22">Marshall S</searchLink>; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Reader+CS%22">Reader CS</searchLink>; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Russell+R%22">Russell R</searchLink>; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Sainson+RCA%22">Sainson RCA</searchLink>; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Seal+CJ%22">Seal CJ</searchLink>; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Shepherd+CJ%22">Shepherd CJ</searchLink>; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Germaschewski+F%22">Germaschewski F</searchLink>; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gliddon+D%22">Gliddon D</searchLink>; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Stern+O%22">Stern O</searchLink>; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Young+L%22">Young L</searchLink>; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Brewis+N%22">Brewis N</searchLink>; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Kayitalire+L%22">Kayitalire L</searchLink>; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Morrow+M%22">Morrow M</searchLink>; F-star Therapeutics Ltd., Babraham Research Campus, Cambridge, United Kingdom.
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  Data: <searchLink fieldCode="JN" term="%229502500%22">Clinical cancer research : an official journal of the American Association for Cancer Research</searchLink> [Clin Cancer Res] 2023 Mar 01; Vol. 29 (5), pp. 888-898.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9502500 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1557-3265 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210780432%22">10780432 </searchLink><i>NLM ISO Abbreviation: </i>Clin Cancer Res <i>Subsets: </i>MEDLINE
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