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Synthesis and Cytotoxic Activity of 1,2,4-Triazolo-Linked Bis-Indolyl Conjugates as Dual Inhibitors of Tankyrase and PI3K.

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Title: Synthesis and Cytotoxic Activity of 1,2,4-Triazolo-Linked Bis-Indolyl Conjugates as Dual Inhibitors of Tankyrase and PI3K.
Authors: Yakkala PA; Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India., Panda SR; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Guwahati 781101, India., Shafi S; Department of Chemistry, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi 110062, India., Naidu VGM; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Guwahati 781101, India., Yar MS; Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India., Ubanako PN; Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa., Adeyemi SA; Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa., Kumar P; Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa., Choonara YE; Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa., Radchenko EV; Department of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia., Palyulin VA; Department of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia., Kamal A; Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.; Department of Pharmacy, Birla Institute of Technology & Science, Pilani, Hyderabad Campus, Hyderabad 500078, India.
Source: Molecules (Basel, Switzerland) [Molecules] 2022 Nov 07; Vol. 27 (21). Date of Electronic Publication: 2022 Nov 07.
Publication Type: Journal Article
Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Synthesis and Cytotoxic Activity of 1,2,4-Triazolo-Linked Bis-Indolyl Conjugates as Dual Inhibitors of Tankyrase and PI3K.
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  Data: <searchLink fieldCode="AU" term="%22Yakkala+PA%22">Yakkala PA</searchLink>; Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.<br /><searchLink fieldCode="AU" term="%22Panda+SR%22">Panda SR</searchLink>; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Guwahati 781101, India.<br /><searchLink fieldCode="AU" term="%22Shafi+S%22">Shafi S</searchLink>; Department of Chemistry, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi 110062, India.<br /><searchLink fieldCode="AU" term="%22Naidu+VGM%22">Naidu VGM</searchLink>; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Guwahati 781101, India.<br /><searchLink fieldCode="AU" term="%22Yar+MS%22">Yar MS</searchLink>; Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.<br /><searchLink fieldCode="AU" term="%22Ubanako+PN%22">Ubanako PN</searchLink>; Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.<br /><searchLink fieldCode="AU" term="%22Adeyemi+SA%22">Adeyemi SA</searchLink>; Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.<br /><searchLink fieldCode="AU" term="%22Kumar+P%22">Kumar P</searchLink>; Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.<br /><searchLink fieldCode="AU" term="%22Choonara+YE%22">Choonara YE</searchLink>; Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.<br /><searchLink fieldCode="AU" term="%22Radchenko+EV%22">Radchenko EV</searchLink>; Department of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Palyulin+VA%22">Palyulin VA</searchLink>; Department of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia.<br /><searchLink fieldCode="AU" term="%22Kamal+A%22">Kamal A</searchLink>; Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India.; Department of Pharmacy, Birla Institute of Technology & Science, Pilani, Hyderabad Campus, Hyderabad 500078, India.
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  Data: <searchLink fieldCode="JN" term="%22100964009%22">Molecules (Basel, Switzerland)</searchLink> [Molecules] 2022 Nov 07; Vol. 27 (21). <i>Date of Electronic Publication: </i>2022 Nov 07.
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