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Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure.

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Title: Genome-wide association and multi-trait analyses characterize the common genetic architecture of heart failure.
Authors: Levin MG; Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA., Tsao NL; Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Singhal P; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Liu C; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Vy HMT; The Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Paranjpe I; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Backman JD; Regeneron Genetics Center, Tarrytown, NY, USA., Bellomo TR; Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Bone WP; Genomics and Computational Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Biddinger KJ; Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA., Hui Q; Emory University School of Public Health, Atlanta, GA, USA.; Atlanta VA Health Care System, Decatur, GA, USA., Dikilitas O; Departments of Internal Medicine and Cardiovascular Medicine, and Mayo Clinician-Investigator Training Program, Mayo Clinic, Rochester, MN, USA., Satterfield BA; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Yang Y; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Morley MP; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Bradford Y; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Burke M; Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Reza N; Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Charest B; Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, MA, USA., Judy RL; Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Puckelwartz MJ; Department of Pharmacology, Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Hakonarson H; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA., Khan A; Division of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY, USA., Kottyan LC; Department of Pediatrics, Division of Human Genetics and Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Kullo I; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA., Luo Y; Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., McNally EM; Center for Genetic Medicine, Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Rasmussen-Torvik LJ; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Day SM; Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Do R; The Charles Bronfman Institute for Personalized Medicine, BioMe Phenomics Center, and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Phillips LS; Atlanta VA Health Care System, Decatur, GA, USA.; Division of Endocrinology, Emory University School of Medicine, Atlanta, GA, USA., Ellinor PT; Program in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center and Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, MA, USA., Nadkarni GN; Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Ritchie MD; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Institute for Biomedical Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Arany Z; Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Cappola TP; Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Margulies KB; Division of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Aragam KG; Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Haggerty CM; Department of Translational Data Science and Informatics and Heart Institute, Geisinger, Danville, PA, USA., Joseph J; Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Sun YV; Emory University School of Public Health, Atlanta, GA, USA.; Atlanta VA Health Care System, Decatur, GA, USA., Voight BF; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Institute of Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Damrauer SM; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA. damrauer@upenn.edu.; Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. damrauer@upenn.edu.
Corporate Authors: Regeneron Genetics Center
Source: Nature communications [Nat Commun] 2022 Nov 14; Vol. 13 (1), pp. 6914. Date of Electronic Publication: 2022 Nov 14.
Publication Type: Meta-Analysis; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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