Characterisation of SARS-CoV-2 genomic variation in response to molnupiravir treatment in the AGILE Phase IIa clinical trial.
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| Title: | Characterisation of SARS-CoV-2 genomic variation in response to molnupiravir treatment in the AGILE Phase IIa clinical trial. |
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| Authors: | Donovan-Banfield I; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, UK., Penrice-Randal R; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK., Goldswain H; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK., Rzeszutek AM; Department of Evolution, Ecology and Behaviour, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK., Pilgrim J; Department of Evolution, Ecology and Behaviour, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK., Bullock K; GCPLab Facility, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Saunders G; Southampton Clinical Trials Unit, University of Southampton, Southampton, UK., Northey J; Southampton Clinical Trials Unit, University of Southampton, Southampton, UK., Dong X; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK., Ryan Y; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK., Reynolds H; Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Tetlow M; Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Walker LE; Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.; NIHR Royal Liverpool and Broadgreen Clinical Research Facility, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK., FitzGerald R; Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.; NIHR Royal Liverpool and Broadgreen Clinical Research Facility, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK., Hale C; NIHR Royal Liverpool and Broadgreen Clinical Research Facility, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK., Lyon R; NIHR Royal Liverpool and Broadgreen Clinical Research Facility, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK., Woods C; NIHR Royal Liverpool and Broadgreen Clinical Research Facility, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK., Ahmad S; NIHR Manchester Clinical Research Facility, Manchester University NHS Foundation Trust, Manchester, UK., Hadjiyiannakis D; NIHR Lancashire Clinical Research Facility, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK., Periselneris J; NIHR Kings Clinical Research Facility, King's College Hospital NHS Foundation Trust, London, UK., Knox E; Southampton Clinical Trials Unit, University of Southampton, Southampton, UK., Middleton C; Southampton Clinical Trials Unit, University of Southampton, Southampton, UK., Lavelle-Langham L; GCPLab Facility, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Shaw V; GCPLab Facility, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.; The Clinical Directorate, University of Liverpool, Liverpool, UK., Greenhalf W; GCPLab Facility, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Edwards T; Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Liverpool, UK., Lalloo DG; Liverpool School of Tropical Medicine, Liverpool, UK., Edwards CJ; Human Development and Health School, University of Southampton, Southampton, UK.; NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Darby AC; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.; NIHR Health Protection Research Unit in Gastrointestinal Infections, Liverpool, UK., Carroll MW; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, UK.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Griffiths G; Southampton Clinical Trials Unit, University of Southampton, Southampton, UK., Khoo SH; Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Hiscox JA; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK. julian.hiscox@liverpool.ac.uk.; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, UK. julian.hiscox@liverpool.ac.uk.; A*STAR Infectious Diseases Laboratories (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. julian.hiscox@liverpool.ac.uk., Fletcher T; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, UK. Tom.Fletcher@lstmed.ac.uk.; Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Liverpool, UK. Tom.Fletcher@lstmed.ac.uk. |
| Source: | Nature communications [Nat Commun] 2022 Nov 26; Vol. 13 (1), pp. 7284. Date of Electronic Publication: 2022 Nov 26. |
| Publication Type: | Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 36435798 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Characterisation of SARS-CoV-2 genomic variation in response to molnupiravir treatment in the AGILE Phase IIa clinical trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Donovan-Banfield+I%22">Donovan-Banfield I</searchLink>; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Penrice-Randal+R%22">Penrice-Randal R</searchLink>; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Goldswain+H%22">Goldswain H</searchLink>; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Rzeszutek+AM%22">Rzeszutek AM</searchLink>; Department of Evolution, Ecology and Behaviour, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Pilgrim+J%22">Pilgrim J</searchLink>; Department of Evolution, Ecology and Behaviour, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Bullock+K%22">Bullock K</searchLink>; GCPLab Facility, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Saunders+G%22">Saunders G</searchLink>; Southampton Clinical Trials Unit, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Northey+J%22">Northey J</searchLink>; Southampton Clinical Trials Unit, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Dong+X%22">Dong X</searchLink>; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Ryan+Y%22">Ryan Y</searchLink>; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Reynolds+H%22">Reynolds H</searchLink>; Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Tetlow+M%22">Tetlow M</searchLink>; Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Walker+LE%22">Walker LE</searchLink>; Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.; NIHR Royal Liverpool and Broadgreen Clinical Research Facility, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22FitzGerald+R%22">FitzGerald R</searchLink>; Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.; NIHR Royal Liverpool and Broadgreen Clinical Research Facility, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Hale+C%22">Hale C</searchLink>; NIHR Royal Liverpool and Broadgreen Clinical Research Facility, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Lyon+R%22">Lyon R</searchLink>; NIHR Royal Liverpool and Broadgreen Clinical Research Facility, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Woods+C%22">Woods C</searchLink>; NIHR Royal Liverpool and Broadgreen Clinical Research Facility, Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Ahmad+S%22">Ahmad S</searchLink>; NIHR Manchester Clinical Research Facility, Manchester University NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Hadjiyiannakis+D%22">Hadjiyiannakis D</searchLink>; NIHR Lancashire Clinical Research Facility, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK.<br /><searchLink fieldCode="AU" term="%22Periselneris+J%22">Periselneris J</searchLink>; NIHR Kings Clinical Research Facility, King's College Hospital NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Knox+E%22">Knox E</searchLink>; Southampton Clinical Trials Unit, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Middleton+C%22">Middleton C</searchLink>; Southampton Clinical Trials Unit, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Lavelle-Langham+L%22">Lavelle-Langham L</searchLink>; GCPLab Facility, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Shaw+V%22">Shaw V</searchLink>; GCPLab Facility, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.; The Clinical Directorate, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Greenhalf+W%22">Greenhalf W</searchLink>; GCPLab Facility, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Edwards+T%22">Edwards T</searchLink>; Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Lalloo+DG%22">Lalloo DG</searchLink>; Liverpool School of Tropical Medicine, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Edwards+CJ%22">Edwards CJ</searchLink>; Human Development and Health School, University of Southampton, Southampton, UK.; NIHR Southampton Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Darby+AC%22">Darby AC</searchLink>; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.; NIHR Health Protection Research Unit in Gastrointestinal Infections, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Carroll+MW%22">Carroll MW</searchLink>; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, UK.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Griffiths+G%22">Griffiths G</searchLink>; Southampton Clinical Trials Unit, University of Southampton, Southampton, UK.<br /><searchLink fieldCode="AU" term="%22Khoo+SH%22">Khoo SH</searchLink>; Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Hiscox+JA%22">Hiscox JA</searchLink>; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK. julian.hiscox@liverpool.ac.uk.; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, UK. julian.hiscox@liverpool.ac.uk.; A*STAR Infectious Diseases Laboratories (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. julian.hiscox@liverpool.ac.uk.<br /><searchLink fieldCode="AU" term="%22Fletcher+T%22">Fletcher T</searchLink>; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, UK. Tom.Fletcher@lstmed.ac.uk.; Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Liverpool, UK. Tom.Fletcher@lstmed.ac.uk. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2022 Nov 26; Vol. 13 (1), pp. 7284. <i>Date of Electronic Publication: </i>2022 Nov 26. – Name: TypePub Label: Publication Type Group: TypPub Data: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE |
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